Organoid technology and applications in cancer research

Development of a functional thyroid model based on an organoid culture system

(2018) Yoshiyuki Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The endosomal protein CEMIP links Wnt signaling to MEK1-ERK1/2 activation in Selumetinib-resistant intestinal organoids

(2018) Hong-Quan Duong et al.   CANCER RESEARCH

Bispecific antibodies in haematological malignancies

(2018) Andreas Viardot et al.   CANCER TREATMENT REVIEWS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Organoid Models of Cancer Explode with Possibilities

(2018) Senthil K. Muthuswamy   Cell Stem Cell

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

Anaplastic Lymphoma Kinase Mutation (ALKF1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib

(2018) Benedito A. Carneiro et al.   CLINICAL CANCER RESEARCH

Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells

(2018) Daichi Onozato et al.   DRUG METABOLISM AND DISPOSITION

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment

(2018) Herve Tiriac et al.   GASTROINTESTINAL ENDOSCOPY

Human gastric cancer modelling using organoids

(2018) Therese Seidlitz et al.   GUT

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

(2018) Tatsuya Usui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy

(2018) Yanyu Pang et al.   Molecular Cancer

Building three-dimensional human brain organoids

(2018) Sergiu Paşca   NATURE NEUROSCIENCE

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Patient derived organoids to model rare prostate cancer phenotypes

(2018) Loredana Puca et al.   Nature Communications

Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids

(2018) Mans Broekgaarden et al.   Oncotarget

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

In Vitro Models for Studying Invasive Transitions of Ductal Carcinoma In Situ

(2018) Ethan J. Brock et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

(2018) Ming Yi et al.   Molecular Cancer

Organoids reveal cancer dynamics

(2018) Calvin J. Kuo et al.   NATURE

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

(2017) Yi-Hua Lai et al.   Journal of Hematology & Oncology

Recent advances of highly selective CDK4/6 inhibitors in breast cancer

(2017) Hanxiao Xu et al.   Journal of Hematology & Oncology

Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy

(2017) Bingshan Liu et al.   Journal of Hematology & Oncology

Recent advances of bispecific antibodies in solid tumors

(2017) Shengnan Yu et al.   Journal of Hematology & Oncology

Exosomal proteins as potential markers of tumor diagnosis

(2017) Aichun Li et al.   Journal of Hematology & Oncology

Current status and perspectives of patient-derived xenograft models in cancer research

(2017) Yunxin Lai et al.   Journal of Hematology & Oncology

CircRNA: functions and properties of a novel potential biomarker for cancer

(2017) Shujuan Meng et al.   Molecular Cancer

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

(2017) Julia Jabs et al.   Molecular Systems Biology

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

(2017) Jatin Roper et al.   NATURE BIOTECHNOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

(2017) Alexandra A Duarte et al.   NATURE METHODS

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

(2017) Niklas K. Finnberg et al.   Oncotarget

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

(2017) Alba Cristobal et al.   Cell Reports

BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

(2017) Naoya Sakamoto et al.   eLife

Human engineered heart tissue as a model system for drug testing

(2016) Alexandra Eder et al.   ADVANCED DRUG DELIVERY REVIEWS

Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering

(2016) Colin R. Butler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2 + T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate

(2016) Nicholas A. Zumwalde et al.   Cancer Prevention Research

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

(2016) Evelyn Fessler et al.   EMBO Molecular Medicine

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

(2016) Helen H N Yan et al.   GUT

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

(2016) Kengo Nozaki et al.   JOURNAL OF GASTROENTEROLOGY

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

(2016) Alex J. Walsh et al.   PANCREAS

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

(2016) Carla S Verissimo et al.   eLife

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

(2015) Yuebang Yin et al.   ANTIVIRAL RESEARCH

SnapShot: Growing Organoids from Stem Cells

(2015) Toshiro Sato et al.   CELL

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

(2015) Tiziana Scanu et al.   Cell Host & Microbe

CRISPR–Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18

(2015) H W Chu et al.   GENE THERAPY

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells

(2015) Xia Gao et al.   JOURNAL OF CELL BIOLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Personalizing pancreatic cancer organoids with hPSCs

(2015) H Chuck Zhang et al.   NATURE MEDICINE

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Stem cells in retinal regeneration: past, present and future

(2013) C. M. Ramsden et al.   DEVELOPMENT

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Genetic reconstitution of tumorigenesis in primary intestinal cells

(2013) K. Onuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Advances in the preclinical testing of cancer therapeutic hypotheses

(2011) Giordano Caponigro et al.   NATURE REVIEWS DRUG DISCOVERY

Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

(2010) Qin Meng   Expert Opinion on Drug Metabolism & Toxicology

Cancer stem cells from colorectal cancer-derived cell lines

(2010) Trevor M. Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

(2008) S.-Y. Sung et al.   CANCER RESEARCH