Nanotoxicology: advances and pitfalls in research methodology

The “Sweet” Side of the Protein Corona: Effects of Glycosylation on Nanoparticle–Cell Interactions

(2015) Sha Wan et al.   ACS Nano

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

(2015) Kenya Murase et al.   MAGNETIC RESONANCE IMAGING

Toxicity of silica nanoparticles depends on size, dose, and cell type

(2015) In-Yong Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide

(2015) Mohammad Javad Hajipour et al.   Nanoscale

Mapping protein binding sites on the biomolecular corona of nanoparticles

(2015) Philip M. Kelly et al.   Nature Nanotechnology

Graphene oxide selectively targets cancer stem cells, across multiple tumor types: Implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”

(2015) Marco Fiorillo et al.   Oncotarget

Cell-Imprinted Substrates Act as an Artificial Niche for Skin Regeneration

(2014) Omid Mashinchian et al.   ACS Applied Materials & Interfaces

Imaging Approach to Mechanistic Study of Nanoparticle Interactions with the Blood–Brain Barrier

(2014) Mattia Bramini et al.   ACS Nano

Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles

(2014) Alexandre Albanese et al.   ACS Nano

Fabrication of Corona-Free Nanoparticles with Tunable Hydrophobicity

(2014) Daniel F. Moyano et al.   ACS Nano

Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles

(2014) Candace C. Fleischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Influence of HepG2 cell shape on nanoparticle uptake

(2014) Batirtze Prats-Mateu et al.   MICROSCOPY RESEARCH AND TECHNIQUE

The Role of Surface Functionality in Nanoparticle Exocytosis

(2014) Chang Soo Kim et al.   Advanced Healthcare Materials

Personalized protein coronas: a “key” factor at the nanobiointerface

(2014) Mohammad J. Hajipour et al.   Biomaterials Science

The Role of Surface Functionality in Determining Nanoparticle Cytotoxicity

(2013) Sung Tae Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cell-Imprinted Substrates Direct the Fate of Stem Cells

(2013) Morteza Mahmoudi et al.   ACS Nano

Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity

(2013) Ramin Sakhtianchi et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Extensive evaluations of the cytotoxic effects of gold nanoparticles

(2013) Show-Mei Chuang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction

(2013) Vahid Serpooshan et al.   BIOMATERIALS

Protein corona significantly reduces active targeting yield

(2013) Vahid Mirshafiee et al.   CHEMICAL COMMUNICATIONS

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

(2013) Jens Rauch et al.   CHEMICAL REVIEWS

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency

(2013) Anna Lesniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

(2013) Morteza Mahmoudi et al.   NANO LETTERS

Slight temperature changes affect protein affinity and cellular uptake/toxicity of nanoparticles

(2013) Morteza Mahmoudi et al.   Nanoscale

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Programmable Cellular Retention of Nanoparticles by Replacing the Synergistic Anion of Transferrin

(2012) Li-Chen Wu et al.   ACS Nano

Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation

(2012) Haiyuan Zhang et al.   ACS Nano

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Real time observation and kinetic modeling of the cellular uptake and removal of silicon quantum dots

(2012) Seiichi Ohta et al.   BIOMATERIALS

Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Diseases with Compromise to the Blood Brain Barrier

(2012) Silke Krol et al.   CHEMICAL REVIEWS

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Significance of cell “observer” and protein source in nanobiosciences

(2012) Sophie Laurent et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins

(2012) Kanlaya Prapainop et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell “vision”: complementary factor of protein corona in nanotoxicology

(2012) Morteza Mahmoudi et al.   Nanoscale

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision”

(2012) Sophie Laurent et al.   PLoS One

Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

(2012) Rolando E. Yanes et al.   Small

Interfacing Engineered Nanoparticles with Biological Systems: Anticipating Adverse Nano-Bio Interactions

(2012) Beatriz Pelaz et al.   Small

Antibacterial properties of nanoparticles

(2012) Mohammad J. Hajipour et al.   TRENDS IN BIOTECHNOLOGY

Plasma concentration gradient influences the protein corona decoration on nanoparticles

(2012) Mahdi Ghavami et al.   RSC Advances

Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models

(2011) Dania Movia et al.   ACS Nano

Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles

(2011) Morteza Mahmoudi et al.   ACS Nano

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles

(2011) Sophie Laurent et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Nanotoxicology: An Interdisciplinary Challenge

(2011) Harald F. Krug et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticles in Biological Systems

(2011) Wendelin J. Stark   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomes

(2011) Yuexian Liu et al.   BIOMATERIALS

Toxicity of nanomaterials

(2011) Shahriar Sharifi et al.   CHEMICAL SOCIETY REVIEWS

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental considerations on the cytotoxicity of nanoparticles

(2011) Bokyung Kong et al.   Nanomedicine

No time to lose—high throughput screening to assess nanomaterial safety

(2011) R. Damoiseaux et al.   Nanoscale

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

(2011) Eun Chul Cho et al.   Nature Nanotechnology

Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles

(2011) Tomasz Puzyn et al.   Nature Nanotechnology

Validation of an LDH assay for assessing nanoparticle toxicity

(2011) Xianglu Han et al.   TOXICOLOGY

Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells

(2011) Maqusood Ahamed et al.   TOXICOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Penetration of Lipid Membranes by Gold Nanoparticles: Insights into Cellular Uptake, Cytotoxicity, and Their Relationship

(2010) Jiaqi Lin et al.   ACS Nano

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

(2010) Morteza Mahmoudi et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine

(2010) Morteza Mahmoudi et al.   CHEMICAL REVIEWS

C-Reactive Protein Uptake by Macrophage Cell Line via Class-A Scavenger Receptor

(2010) Y. Fujita et al.   CLINICAL CHEMISTRY

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

(2010) Alaaldin M. Alkilany et al.   JOURNAL OF NANOPARTICLE RESEARCH

Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes

(2010) Ioannis S. Vizirianakis   Nanomedicine-Nanotechnology Biology and Medicine

An index for characterization of nanomaterials in biological systems

(2010) Xin-Rui Xia et al.   Nature Nanotechnology

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

The Path to Personalized Medicine

(2010) Margaret A. Hamburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanomaterial cytotoxicity is composition, size, and cell type dependent

(2010) Syed K Sohaebuddin et al.   Particle and Fibre Toxicology

Comparative Study of Predictive Computational Models for Nanoparticle-Induced Cytotoxicity

(2010) Christie Sayes et al.   RISK ANALYSIS

In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

(2010) Qianjun He et al.   Small

Effects of water-soluble functionalized multi-walled carbon nanotubes examined by different cytotoxicity methods in human astrocyte D384 and lung A549 cells

(2010) T. Coccini et al.   TOXICOLOGY

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

Inorganic Nanoparticles for MRI Contrast Agents

(2009) Hyon Bin Na et al.   ADVANCED MATERIALS

Analytical methods to assess nanoparticle toxicity

(2009) Bryce J. Marquis et al.   ANALYST

Study of uptake and loss of silica nanoparticles in living human lung epithelial cells at single cell level

(2009) Isaac Stayton et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials

(2009) Neenu Singh et al.   BIOMATERIALS

Specific Targeting of Brain Tumors with an Optical/Magnetic Resonance Imaging Nanoprobe across the Blood-Brain Barrier

(2009) O. Veiseh et al.   CANCER RESEARCH

A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles

(2009) Morteza Mahmoudi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Development ofin vitrosystems for nanotoxicology: methodological considerations

(2009) Vicki Stone et al.   CRITICAL REVIEWS IN TOXICOLOGY

Understanding the Role of Surface Charges in Cellular Adsorption versus Internalization by Selectively Removing Gold Nanoparticles on the Cell Surface with a I2/KI Etchant

(2009) Eun Chul Cho et al.   NANO LETTERS

Selective cytotoxic effect of ZnO nanoparticles on glioma cells

(2009) Stella Ostrovsky et al.   Nano Research

The status ofin vitrotoxicity studies in the risk assessment of nanomaterials

(2009) Margriet VDZ Park et al.   Nanomedicine

Anin vitrostudy of bare and poly(ethylene glycol)-co-fumarate-coated superparamagnetic iron oxide nanoparticles: a new toxicity identification procedure

(2009) Morteza Mahmoudi et al.   NANOTECHNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology

Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects

(2009) Alaaldin M. Alkilany et al.   Small

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Assessing nanotoxicity in cells in vitro

(2009) Jedd M. Hillegass et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles

(2008) Partha S. Ghosh et al.   ACS Nano

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

(2008) P. V. AshaRani et al.   ACS Nano

Multifunctional magnetic nanoparticles for targeted imaging and therapy☆

(2008) J MCCARTHY et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Current in vitro methods in nanoparticle risk assessment: Limitations and challenges

(2008) Alexandra Kroll et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Concordance BetweenInVitroandInVivoDosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar Region

(2008) K. Donaldson et al.   INHALATION TOXICOLOGY

Cellular Uptake and Cytotoxicity of Silica Nanotubes

(2008) Anjan Nan et al.   NANO LETTERS

Interaction of Nanoparticles with Lipid Membrane

(2008) Yuri Roiter et al.   NANO LETTERS

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cells

(2008) A. Casey et al.   TOXICOLOGY LETTERS

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small