Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies

(2013) Chandraiah Godugu et al.   PLoS One

Toward the Development of Decision Supporting Tools That Can Be Used for Safe Production and Use of Nanomaterials

(2012) Claudia Som et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Biologically Effective Dose in Inhalation Nanotoxicology

(2012) Ken Donaldson et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Silico Analysis of Nanomaterials Hazard and Risk

(2012) Yoram Cohen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Challenge To Relate the Physicochemical Properties of Colloidal Nanoparticles to Their Cytotoxicity

(2012) Pilar Rivera-Gil et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cytotoxic Effects of Gold Nanoparticles: A Multiparametric Study

(2012) Stefaan J. Soenen et al.   ACS Nano

Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress

(2012) Francesca Pagliari et al.   ACS Nano

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Pegylated Phospholipid Micelles Induce Endoplasmic Reticulum-Dependent Apoptosis of Cancer Cells but not Normal Cells

(2012) Jing Wang et al.   ACS Nano

Cellular Uptake of Nanoparticles by Membrane Penetration: A Study Combining Confocal Microscopy with FTIR Spectroelectrochemistry

(2012) Tiantian Wang et al.   ACS Nano

Three-Dimensional Microtissue Assay for High-Throughput Cytotoxicity of Nanoparticles

(2012) Yang Luo et al.   ANALYTICAL CHEMISTRY

Ultrasensitive and Selective Electrochemical Diagnosis of Breast Cancer Based on a Hydrazine–Au Nanoparticle–Aptamer Bioconjugate

(2012) Ye Zhu et al.   ANALYTICAL CHEMISTRY

Tumor-Homing Poly-siRNA/Glycol Chitosan Self-Cross-Linked Nanoparticles for Systemic siRNA Delivery in Cancer Treatment

(2012) So Jin Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic System for Facilitated Quantification of Nanoparticle Accumulation to Cells Under Laminar Flow

(2012) Jiro Kusunose et al.   ANNALS OF BIOMEDICAL ENGINEERING

Interference of engineered nanoparticles with in vitro toxicity assays

(2012) Alexandra Kroll et al.   ARCHIVES OF TOXICOLOGY

The cytotoxic effects of polymer-coated quantum dots and restrictions for live cell applications

(2012) Stefaan J. Soenen et al.   BIOMATERIALS

Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia

(2012) Josephine Pinkernelle et al.   BMC NEUROSCIENCE

Flotillin-involved uptake of silica nanoparticles and responses of an alveolar-capillary barrier in vitro

(2012) Jennifer Kasper et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture

(2012) Miao Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

(2012) Jonathan Coulter   International Journal of Nanomedicine

Can Standard Genotoxicity Tests be Applied to Nanoparticles?

(2012) Zuzana Magdolenova et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Tracking T-cells in vivo with a new nano-sized MRI contrast agent

(2012) Li Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging

(2012) Dickson K. Kirui et al.   Nanomedicine-Nanotechnology Biology and Medicine

M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer

(2012) Debadyuti Ghosh et al.   Nature Nanotechnology

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision”

(2012) Sophie Laurent et al.   PLoS One

TiO2 nanoparticles induce endothelial cell activation in a pneumocyte–endothelial co-culture model

(2012) María del Pilar Ramos-Godínez et al.   TOXICOLOGY IN VITRO

Quantum Dots: An Insight and Perspective of Their Biological Interaction and How This Relates to Their Relevance for Clinical Use

(2012) Martin J. D. Clift et al.   Theranostics

Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge

(2012) Christoph Schweiger et al.   JOURNAL OF NANOBIOTECHNOLOGY

Common nano-materials and their use in real world applications

(2012) Robin A. McIntyre   SCIENCE PROGRESS

Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials

(2011) Saji George et al.   ACS Nano

Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models

(2011) Dania Movia et al.   ACS Nano

Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells

(2011) Haiyuan Zhang et al.   ACS Nano

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles

(2011) Morteza Mahmoudi et al.   ACS Nano

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticles

(2011) C. Greulich et al.   Acta Biomaterialia

Physical and chemical stability of drug nanoparticles

(2011) Libo Wu et al.   ADVANCED DRUG DELIVERY REVIEWS

Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects

(2011) Daniela Drescher et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Dextran Coated Ultrafine Superparamagnetic Iron Oxide Nanoparticles: Compatibility with Common Fluorometric and Colorimetric Dyes

(2011) Sioned M. Griffiths et al.   ANALYTICAL CHEMISTRY

On-Chip Evaluation of Shear Stress Effect on Cytotoxicity of Mesoporous Silica Nanoparticles

(2011) Donghyuk Kim et al.   ANALYTICAL CHEMISTRY

Nanotoxicology: An Interdisciplinary Challenge

(2011) Harald F. Krug et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms

(2011) Alicia Fernandez-Fernandez et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Repetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ cultures

(2011) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Regulatory Approaches to Worker Protection in Nanotechnology Industry in the USA and European Union

(2011) Vladimir MURASHOV et al.   INDUSTRIAL HEALTH

Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1

(2011) Tridib Bhowmick et al.   JOURNAL OF CONTROLLED RELEASE

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

(2011) S.H. Doak et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation

(2011) Stefaan J. Soenen et al.   Nano Today

No time to lose—high throughput screening to assess nanomaterial safety

(2011) R. Damoiseaux et al.   Nanoscale

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

(2011) Eun Chul Cho et al.   Nature Nanotechnology

Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles

(2011) Tomasz Puzyn et al.   Nature Nanotechnology

Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures

(2011) Jennifer Kasper et al.   Particle and Fibre Toxicology

A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells

(2011) Yonggang Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Nanotoxicology and in vitro studies: The need of the hour

(2011) Sumit Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines

(2011) Sanchali Gupta Mukherjee et al.   TOXICOLOGY IN VITRO

The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells

(2011) Anna Lankoff et al.   TOXICOLOGY LETTERS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward

(2011) David Y. Lai   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Alternative in vitro assays in nanomaterial toxicology

(2011) Thomas Hartung et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Effects of Cell Culture Media on the Dynamic Formation of Protein−Nanoparticle Complexes and Influence on the Cellular Response

(2010) Gabriele Maiorano et al.   ACS Nano

Toxicity assessment of nanomaterials: methods and challenges

(2010) Alok Dhawan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effects of Shear Stress and Stretch on Endothelial Function

(2010) Joji Ando et al.   ANTIOXIDANTS & REDOX SIGNALING

Nanoparticles: molecular targets and cell signalling

(2010) Francelyne Marano et al.   ARCHIVES OF TOXICOLOGY

Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling

(2010) Stefaan J.H. Soenen et al.   BIOMATERIALS

A new perspective on in vitro assessment method for evaluating quantum dot toxicity by using microfluidics technology

(2010) Sanjeev Kumar Mahto et al.   Biomicrofluidics

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

(2010) Helinor J. Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Bacterial cytotoxicity of the silver nanoparticle related to physicochemical metrics and agglomeration properties

(2010) Eunjoo Bae et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Secondary cytotoxicity mediated by alveolar macrophages: A contribution to the total efficacy of nanoparticles in lung cancer therapy?

(2010) Kamal M.H.D Al-Hallak et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles

(2010) Damien van Berlo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation

(2010) Kivilcim Buyukhatipoglu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Agglomeration, sedimentation, and cellular toxicity of alumina nanoparticles in cell culture medium

(2010) Dokyung Yoon et al.   JOURNAL OF NANOPARTICLE RESEARCH

Silver nanoparticles in simulated biological media: a study of aggregation, sedimentation, and dissolution

(2010) Larissa V. Stebounova et al.   JOURNAL OF NANOPARTICLE RESEARCH

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Controlled synthesis and biomolecular probe application of gold nanoparticles

(2010) Dung The Nguyen et al.   MICRON

Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking

(2010) Kevin Braeckmans et al.   NANO LETTERS

Assessing iron oxide nanoparticle toxicityin vitro: current status and future prospects

(2010) Stefaan JH Soenen et al.   Nanomedicine

Interaction of multi-functional silver nanoparticles with living cells

(2010) Ilknur Sur et al.   NANOTECHNOLOGY

Stable nanoparticle aggregates/agglomerates of different sizes and the effect of their size on hemolytic cytotoxicity

(2010) Justin M. Zook et al.   Nanotoxicology

Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation

(2010) Ilse Gosens et al.   Particle and Fibre Toxicology

Nanomaterial cytotoxicity is composition, size, and cell type dependent

(2010) Syed K Sohaebuddin et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond

(2010) A. D. Maynard et al.   TOXICOLOGICAL SCIENCES

Risk assessment of engineered nanomaterials and nanotechnologies—A review

(2010) Kai Savolainen et al.   TOXICOLOGY

Assessment of cytocompatibility of surface-modified CdSe/ZnSe quantum dots for BALB/3T3 fibroblast cells

(2010) Sanjeev Kumar Mahto et al.   TOXICOLOGY IN VITRO

Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100nm or less

(2010) Masanori Horie et al.   TOXICOLOGY IN VITRO

Cathepsin L Digestion of Nanobioconjugates upon Endocytosis

(2009) Violaine Sée et al.   ACS Nano

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

Toxicity Evaluation for Safe Use of Nanomaterials: Recent Achievements and Technical Challenges

(2009) Saber M. Hussain et al.   ADVANCED MATERIALS

The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

(2009) Dong-Ming Huang et al.   BIOMATERIALS

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials

(2009) Neenu Singh et al.   BIOMATERIALS

Quantum Dot Nanotoxicity Assessment Using the Zebrafish Embryo

(2009) Tisha C. King-Heiden et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Preparation of nanoparticle dispersions for in-vitro toxicity testing

(2009) M. Vippola et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways

(2009) L. Muller et al.   Journal of the Royal Society Interface

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology

Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide

(2009) Tina M Sager et al.   Particle and Fibre Toxicology

The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles

(2009) Ken Donaldson et al.   Particle and Fibre Toxicology

Toxicity Assessments of Multisized Gold and Silver Nanoparticles in Zebrafish Embryos

(2009) Ofek Bar-Ilan et al.   Small

Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice

(2009) Unni C. Nygaard et al.   TOXICOLOGICAL SCIENCES

Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines

(2009) Lisa Bregoli et al.   TOXICOLOGY

Nuclear penetration of surface functionalized gold nanoparticles

(2009) Yan-Juan Gu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages

(2009) Catrin Albrecht et al.   TOXICOLOGY IN VITRO

Characterization of nanomaterials for toxicity assessment

(2009) Christie M. Sayes et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Assessing nanotoxicity in cells in vitro

(2009) Jedd M. Hillegass et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles

(2008) Edward Jan et al.   ACS Nano

3-D Tissue Culture Systems for the Evaluation and Optimization of Nanoparticle-Based Drug Carriers

(2008) Thomas Tyrel Goodman et al.   BIOCONJUGATE CHEMISTRY

Agglomeration and sedimentation of TiO2 nanoparticles in cell culture medium

(2008) Zouhir E. Allouni et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles

(2008) Martin Hassellöv et al.   ECOTOXICOLOGY

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

(2008) Su Jin Kang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Current in vitro methods in nanoparticle risk assessment: Limitations and challenges

(2008) Alexandra Kroll et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10

(2008) E. Alfaro-Moreno et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms of actin stress fibre assembly

(2008) P. NAUMANEN et al.   JOURNAL OF MICROSCOPY

Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice

(2008) Bing Wang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Can in vitro assays substitute for in vivo studies in assessing the pulmonary hazards of fine and nanoscale materials?

(2008) Christie M. Sayes et al.   JOURNAL OF NANOPARTICLE RESEARCH

Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies

(2008) Jingkun Jiang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles

(2008) Cory Hanley et al.   NANOTECHNOLOGY

A biocompatible medium for nanoparticle dispersion

(2008) Dale Porter et al.   Nanotoxicology

Optimized dispersion of nanoparticles for biological in vitro and in vivo studies

(2008) Peter Bihari et al.   Particle and Fibre Toxicology

Review of health safety aspects of nanotechnologies in food production

(2008) Hans Bouwmeester et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Assessing Methods for Blood Cell Cytotoxic Responses to Inorganic Nanoparticles and Nanoparticle Aggregates

(2008) Belén Díaz et al.   Small

Cancer-Cell-Phenotype-Dependent Differential Intracellular Trafficking of Unconjugated Quantum Dots

(2008) Sutapa Barua et al.   Small

Nominal and Effective Dosimetry of Silica Nanoparticles in Cytotoxicity Assays

(2008) Dominique Lison et al.   TOXICOLOGICAL SCIENCES

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

(2008) N.A. Monteiro-Riviere et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS

Ultrasensitive detection and molecular imaging with magnetic nanoparticles

(2007) Jian Yang et al.   ANALYST

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small