Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

Nanomaterial Categorization for Assessing Risk Potential To Facilitate Regulatory Decision-Making

(2015) Hilary Godwin et al.   ACS Nano

A comparative assessment of cigarette smoke aerosols using anin vitroair–liquid interface cytotoxicity test

(2015) David Thorne et al.   INHALATION TOXICOLOGY

MutAIT: an online genetic toxicology data portal and analysis tools

(2015) Daniele Avancini et al.   MUTAGENESIS

Nanotoxicology: advances and pitfalls in research methodology

(2015) Morteza Azhdarzadeh et al.   Nanomedicine

Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints

(2015) Bella B. Manshian et al.   TOXICOLOGICAL SCIENCES

Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol

(2015) Louise Neilson et al.   TOXICOLOGY IN VITRO

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

(2014) G.E. Johnson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses

(2014) K. E. Chapman et al.   MUTAGENESIS

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

(2014) A. L. Seager et al.   MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents

(2014) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

(2014) Alicja Panas et al.   Beilstein Journal of Nanotechnology

Techniques for physicochemical characterization of nanomaterials

(2013) Ping-Chang Lin et al.   BIOTECHNOLOGY ADVANCES

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds

(2013) Sarah Heilmann et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Cosmetics Europe strategy for animal-free genotoxicity testing: Project status up-date

(2013) S. Pfuhler et al.   TOXICOLOGY IN VITRO

Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles

(2013) Mahmoud Elsabahy et al.   Scientific Reports

Whole-Body Nanoparticle Aerosol Inhalation Exposures

(2013) Jinghai Yi et al.   Jove-Journal of Visualized Experiments

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Three-Dimensional Microtissue Assay for High-Throughput Cytotoxicity of Nanoparticles

(2012) Yang Luo et al.   ANALYTICAL CHEMISTRY

Quantitative characterization of nanoparticle agglomeration within biological media

(2012) Nicole Hondow et al.   JOURNAL OF NANOPARTICLE RESEARCH

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

(2012) Thomas R. Downs et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2012) Marilyn J. Aardema et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Interactions of engineered nanomaterials in physiological media and implications forin vitrodosimetry

(2012) Joel Cohen et al.   Nanotoxicology

Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models

(2011) Dania Movia et al.   ACS Nano

Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential

(2011) Sumit Gangwal et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

(2011) S.H. Doak et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

(2011) Chiara Uboldi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

(2011) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Serum proteins prevent aggregation of Fe2O3and ZnO nanoparticles

(2011) Mark A. Wells et al.   Nanotoxicology

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes

(2011) Hiromi Nabeshi et al.   Particle and Fibre Toxicology

Nanotoxicology and in vitro studies: The need of the hour

(2011) Sumit Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method

(2010) Sang Hoon Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum heat inactivation affects protein corona composition and nanoparticle uptake

(2010) Anna Lesniak et al.   BIOMATERIALS

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptations of the in vitro MN assay for the genotoxicity assessment of nanomaterials

(2010) L. Gonzalez et al.   MUTAGENESIS

International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility

(2010) Marilyn J. Aardema et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: Detailed protocol and harmonized scoring atlas

(2010) Erica L. Dahl et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmidlacZgene mutation assay

(2010) Margriet V. D. Z. Park et al.   Nanotoxicology

Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models

(2010) Laetitia Gonzalez et al.   Nanotoxicology

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells

(2010) Mohd Javed Akhtar et al.   TOXICOLOGY

Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin

(2010) T. Hu et al.   TOXICOLOGY IN VITRO

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials

(2009) Neenu Singh et al.   BIOMATERIALS

Confounding experimental considerations in nanogenotoxicology

(2009) S.H. Doak et al.   MUTAGENESIS

Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2009) Ting Hu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Further development of the EpiDerm™ 3D reconstructed human skin micronucleus (RSMN) assay

(2009) Greg C. Mun et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The relationship between pH and zeta potential of ∼ 30 nm metal oxide nanoparticle suspensions relevant toin vitrotoxicological evaluations

(2009) J. Michael Berg et al.   Nanotoxicology

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology

The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles

(2009) Ken Donaldson et al.   Particle and Fibre Toxicology

In vitro Toxicity Testing of Nanoparticles in 3D Cell Culture

(2009) Jungwoo Lee et al.   Small

Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin

(2009) Neera V. Gopee et al.   TOXICOLOGICAL SCIENCES

Assessment of dermal toxicity of nanosilica using cultured keratinocytes, a human skin equivalent model and an in vivo model

(2009) Yoon-Hee Park et al.   TOXICOLOGY

Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure

(2009) Jianhong Wu et al.   TOXICOLOGY LETTERS

Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells

(2008) Maricica Pacurari et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Genotoxicity of engineered nanomaterials: A critical review

(2008) Laetitia Gonzalez et al.   Nanotoxicology

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles: pharmacological and toxicological significance

(2007) C Medina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small