Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

Natriuretic peptides modulate ATP-sensitive K+ channels in rat ventricular cardiomyocytes

(2014) Dwaine S. Burley et al.   BASIC RESEARCH IN CARDIOLOGY

Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue

(2013) Claudia Crocini et al.   BASIC RESEARCH IN CARDIOLOGY

Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice

(2013) Andrea Stöhr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased afterload induces pathological cardiac hypertrophy: a new in vitro model

(2012) Marc N. Hirt et al.   BASIC RESEARCH IN CARDIOLOGY

Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

(2012) Hua Rong Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry

(2012) Fabio Cerignoli et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

(2011) L Nalos et al.   BRITISH JOURNAL OF PHARMACOLOGY

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

(2011) Sebastian Schaaf et al.   PLoS One

Defining a New Paradigm for Human Arrhythmia Syndromes

(2010) Michael J. Ackerman et al.   CIRCULATION RESEARCH

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants

(2010) Jian-Yong Qian et al.   TOXICOLOGY IN VITRO

An Ion Channel Library for Drug Discovery and Safety Screening on Automated Platforms

(2009) Barbara A. Wible et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Inotropy and L-type Ca2+current, activated by β1- and β2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart

(2009) Torsten Christ et al.   BRITISH JOURNAL OF PHARMACOLOGY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

(2009) Stefan R. Braam et al.   Stem Cell Research

High throughput functional screening of an ion channel library for drug safety and efficacy

(2008) Arthur M. Brown   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants

(2008) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

(2008) Gary A. Gintant   PHARMACOLOGY & THERAPEUTICS