Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Nutrient transceptors physically interact with the yeast S6/Protein kinase B homolog, Sch9, a TOR kinase target

(2021) Zhiqiang Zhang et al.   BIOCHEMICAL JOURNAL

Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin

(2021) Natalia Sławińska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute acetate administration increases endogenous opioid levels in the human brain: A [11C]carfentanil molecular imaging study

(2021) Abhishekh H Ashok et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

(2021) Wei Wang et al.   Science Translational Medicine

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism

(2021) Gil Myoung Kang et al.   Cell Metabolism

Ghrelin as a treatment for amyotrophic lateral sclerosis

(2021) Shyuan T. Ngo et al.   JOURNAL OF NEUROENDOCRINOLOGY

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

(2021) He Huang et al.   Science Advances

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

(2020) Casey E. Hughes et al.   CELL

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

(2020) Xiong Wang et al.   Genes and Nutrition

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Autophagy, Cellular Aging and Age-related Human Diseases

(2020) So Yeong Cheon et al.   Experimental Neurobiology

Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines

(2020) Boyue Huang et al.   AGING CELL

Acetylation of STX17 (syntaxin 17) controls autophagosome maturation

(2020) Qiuhong Shen et al.   Autophagy

The Contribution of Astrocyte Autophagy to Systemic Metabolism

(2020) Ana Ortiz-Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Tumor necrosis factor α reduces gonadotropin-releasing hormone release through increase of forkhead box protein O1 activity

(2020) Chun Shi et al.   NEUROREPORT

Aging alters acetylation status in skeletal and cardiac muscles

(2020) Dongwook Yeo et al.   GeroScience

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver

(2020) Mohamad M. Kronfol et al.   GeroScience

Characterization of Fatty Acid Composition Underlying Hypothalamic Inflammation in Aged Mice

(2020) Ye Jin Kim et al.   MOLECULES

Leucine regulates autophagy via acetylation of the mTORC1 component raptor

(2020) Sung Min Son et al.   Nature Communications

NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

(2020) Di Zhu et al.   Science Advances

A chemical biology approach to identifying molecular pathways associated with aging

(2020) Antonio Currais et al.   GeroScience

TIP60 in Aging and Neurodegeneration

(2020) Zhiquan Li et al.   AGEING RESEARCH REVIEWS

GCN5 acetyltransferase in cellular energetic and metabolic processes

(2020) Beste Mutlu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

(2020) Samantha D. Creighton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prolonged fasting induces long-lasting metabolic consequences in mice

(2020) João A.B. Pedroso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

(2020) Raffaella Nativio et al.   NATURE GENETICS

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

(2020) Li-Wa Shao et al.   Nature Communications

The Pathophysiological Role of CoA

(2020) Aleksandra Czumaj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Role for histone deacetylation in traumatic brain injury-induced deficits in neuropeptide Y in arcuate nucleus: Possible implications in feeding behaviour

(2020) Nagalakshmi Balasubramanian et al.   NEUROENDOCRINOLOGY

Forkhead transcription factor FOXO1 is involved in hypoxia/reoxygenation-induced gonadotropin-releasing hormone decline

(2020) Chun Shi et al.   NEUROREPORT

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

(2020) Md Habibur Rahman et al.   Nature Communications

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

(2020) Ryan Houston et al.   PLOS BIOLOGY

Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease

(2020) Niklas Reich et al.   Frontiers in Neuroscience

ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue

(2020) Katsumi Iizuka et al.   Frontiers in Endocrinology

The “great” controlling nucleotide coenzymes

(2019) Richard L. Veech et al.   IUBMB LIFE

Signaling and Regulation of the Mitochondrial Unfolded Protein Response

(2019) Nandhitha Uma Naresh et al.   Cold Spring Harbor Perspectives in Biology

Histone Modifications as an Intersection Between Diet and Longevity

(2019) Diego Molina-Serrano et al.   Frontiers in Genetics

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

(2019) Payel Sen et al.   MOLECULAR CELL

Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice

(2019) Zhouguang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress

(2019) Lei Zhou et al.   PLoS Genetics

Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

(2019) Prabakaran Nagarajan et al.   AGING CELL

The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines

(2019) Matthew Sherrier et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma

(2019) Ya-Hui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

(2019) Karla Rubio et al.   Nature Communications

Neuroepigenetic signatures of age and sex in the living human brain

(2019) Tonya M. Gilbert et al.   Nature Communications

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

(2019) Rebecca L McIntyre et al.   EMBO Molecular Medicine

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

(2019) Yue Zhang et al.   eLife

PCAF regulates H3 phosphorylation and promotes autophagy in osteosarcoma cells

(2019) Daliang Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

(2019) Yusha Wang et al.   EMBO REPORTS

Alcohol metabolism contributes to brain histone acetylation

(2019) P. Mews et al.   NATURE

Elevating acetyl-CoA levels reduces aspects of brain aging

(2019) Antonio Currais et al.   eLife

Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma

(2019) Xueying Yang et al.   Frontiers in Oncology

CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle

(2019) Michal Lipinski et al.   CURRENT OPINION IN NEUROBIOLOGY

Glycolysis regulates gene expression by promoting the crosstalk between H3K4 trimethylation and H3K14 acetylation in Saccharomyces cerevisiae

(2019) Yinsheng Wu et al.   Journal of Genetics and Genomics

The vital role of ATP citrate lyase in chronic diseases

(2019) Amrita Devi Khwairakpam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans

(2019) Jonathan Alcántar-Fernández et al.   PLoS One

Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS ® ) ingestion

(2018) Benjamin Gronier et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Adaptation to metabolic dysfunction during aging: Making the best of a bad situation

(2018) S. Michal Jazwinski et al.   EXPERIMENTAL GERONTOLOGY

Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri

(2018) Gordin Zupkovitz et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Histone deacetylase–mediated regulation of endolysosomal pH

(2018) Hari Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A

(2018) Qingqing Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

Intermittent food restriction in female rats induces SREBP high expression in hypothalamus and immediately postfasting hyperphagia

(2018) Mariana Alejandra Rosas Fernández et al.   NUTRITION

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation

(2018) Hao Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain

(2018) Anna Ronowska et al.   Frontiers in Cellular Neuroscience

Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue

(2018) Lore Becker et al.   Scientific Reports

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

(2018) Gina Cavaliere et al.   Frontiers in Physiology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

(2018) Xiaojing Liu et al.   CELL

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Deacetylation of Histone H4 Accompanying Cardiomyogenesis is Weakened in HDAC1-Depleted ES Cells

(2018) Orazio Angelo Arcidiacono et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APOE Alleles and Extreme Human Longevity

(2018) Paola Sebastiani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

(2018) Jonathan B. Baell et al.   NATURE

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

(2018) Zhiguang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

(2018) Ning-Ning Liu et al.   PLoS Pathogens

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

(2018) Arwen W. Gao et al.   EXPERIMENTAL GERONTOLOGY

Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance

(2018) Baile Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons

(2018) Alejandro Medrano-Fernández et al.   MOLECULAR NEUROBIOLOGY

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

(2018) Katharina Timper et al.   Cell Reports

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

(2018) Diego Hernández-Saavedra et al.   Advances in Nutrition

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53

(2017) Maria Mrakovcic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

(2017) Alessandro Carrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation

(2017) Benjamin D. Rowlands et al.   JOURNAL OF NEUROCHEMISTRY

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

(2017) Robert J. Pawlosky et al.   JOURNAL OF NEUROCHEMISTRY

Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis

(2017) Amber C. Chevalier et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

(2017) Huaihan Cai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HDAC inhibitors: A new promising drug class in anti-aging research

(2017) Elena G. Pasyukova et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway

(2017) Margaret B. Wierman et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet

(2017) Cesar L. Moreno et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection

(2017) Yevgeniya Shurubor et al.   MOLECULES

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

The long-term relationship between dietary pantothenic acid (vitamin B 5 ) intake and C-reactive protein concentration in adults aged 40 years and older

(2017) S. Jung et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A Ketone Ester Drink Lowers Human Ghrelin and Appetite

(2017) Brianna J. Stubbs et al.   Obesity

Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim

(2017) Yanna Wu et al.   Cell Death & Disease

The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism

(2017) Guang Shi et al.   Cell Reports

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

(2017) Chang Geon Chung et al.   Cell Reports

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)

(2017) Jinsung Yang et al.   PLoS Genetics

Inhibition of Histone Methyltransferase, Histone Deacetylase, and β-Catenin Synergistically Enhance the Cardiac Potential of Bone Marrow Cells

(2017) Jinpu Yang et al.   Stem Cells International

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

(2017) Devin Wahl et al.   Clinical Interventions in Aging

Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential

(2017) Priya Balasubramanian et al.   EBioMedicine

Age-dependent obesity and mitochondrial dysfunction

(2017) Qilong Oscar Yang Li et al.   Adipocyte

Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells

(2017) Rui Chen et al.   PLoS One

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Fragile lifespan expansion by dietary mitohormesis in C. elegans

(2016) Arnaud Tauffenberger et al.   Aging-US

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation

(2016) Marisa Ferreira-Marques et al.   Aging-US

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity

(2016) Diego Molina‐Serrano et al.   EMBO REPORTS

Life span extension by targeting a link between metabolism and histone acetylation inDrosophila

(2016) Shahaf Peleg et al.   EMBO REPORTS

Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin

(2016) Nicole H. Rogers et al.   ENDOCRINOLOGY

Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation

(2016) Deborah M. Thurtle-Schmidt et al.   GENETICS

Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation

(2016) Jason J. Workman et al.   GENETICS

Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae

(2016) J. C. Jiang et al.   GENETICS

Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy

(2016) Diane M. Jaworski et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

(2016) Krisztina Marosi et al.   JOURNAL OF NEUROCHEMISTRY

H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus

(2016) S. Snigdha et al.   JOURNAL OF NEUROSCIENCE

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

Structure of p300 in complex with acyl-CoA variants

(2016) Zuzanna Kaczmarska et al.   Nature Chemical Biology

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT

(2016) Cesar L. Moreno et al.   NEUROBIOLOGY OF DISEASE

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

(2016) Dong Kong et al.   NEURON

Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge

(2016) Natalie Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual variability in human blood metabolites identifies age-related differences

(2016) Romanas Chaleckis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis

(2016) Seema Singh et al.   PSYCHOPHARMACOLOGY

P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy

(2016) Yu-Li Jia et al.   Cell Death & Disease

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons

(2016) Ernest Palomer et al.   Cell Reports

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

(2016) Steven Zhao et al.   Cell Reports

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast

(2016) Cihan Erkut et al.   eLife

Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation

(2016) Deborah M. Thurtle-Schmidt et al.   GENETICS

Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation

(2016) Jason J. Workman et al.   GENETICS

Does hypothalamic SIRT1 regulate aging?

(2016) Giorgio Ramadori et al.   Aging-US

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

(2016) Ara B. Hwang et al.   Aging-US

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

(2016) Rachel Whitaker et al.   Aging-US

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Hypothalamic Sirt1 in aging

(2016) Akiko Satoh et al.   Aging-US

Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates

(2016) Cesar L. Moreno et al.   PLoS One

Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging

(2016) Heng-hao Xu et al.   Scientific Reports

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae

(2015) Hong-Jing Cui et al.   AGE

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

(2015) Jianbin Zhang et al.   Autophagy

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

(2015) Clare Edwards et al.   BMC GENETICS

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

(2015) Kristopher Burkewitz et al.   CELL

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest

(2015) Patrick M. Long et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

(2015) Zheng Tan et al.   JOURNAL OF IMMUNOLOGY

Brain metabolism and Alzheimer’s disease: The prospect of a metabolite-based therapy

(2015) S. C. Thomas et al.   Journal of Nutrition Health & Aging

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

(2015) Rui Chen et al.   PLoS One

Interplay among Gcn5, Sch9 and Mitochondria during Chronological Aging of Wine Yeast Is Dependent on Growth Conditions

(2015) Cecilia Picazo et al.   PLoS One

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress

(2015) Jong Woo Lee et al.   PLoS One

Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease

(2015) Timothy Cutler et al.   PLoS One

A histone point mutation that switches on autophagy

(2014) Tobias Eisenberg et al.   Autophagy

Cracking the survival code

(2014) Jens Füllgrabe et al.   Autophagy

Deregulated coenzyme A, loss of metabolic flexibility and diabetes

(2014) Suzanne Jackowski et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

(2014) Hai-Bin Ruan et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway

(2014) Jong-Hyuk Lee et al.   FEBS Journal

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

A central role for the mammalian target of rapamycin in LPS-induced anorexia in mice

(2014) Yunshuang Yue et al.   JOURNAL OF ENDOCRINOLOGY

LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism

(2014) Geert Depuydt et al.   JOURNAL OF PROTEOME RESEARCH

Royal Jelly-Mediated Prolongevity and Stress Resistance in Caenorhabditis elegans Is Possibly Modulated by the Interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 Proteins

(2014) Xiaoxia Wang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nordihydroguaiaretic Acid Extends the Lifespan ofDrosophilaand Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice

(2014) Stephen R. Spindler et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension

(2013) Jessica Stephan et al.   AGING CELL

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Differences in Specificity and Selectivity Between CBP and p300 Acetylation of Histone H3 and H3/H4

(2013) Ryan A. Henry et al.   BIOCHEMISTRY

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Histone Deacetylase 2 in the Mouse Hippocampus: Attenuation of Age- Related Increase by Caloric Restriction

(2013) Leonidas Chouliaras et al.   Current Alzheimer Research

CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development

(2013) David Tsui et al.   DEVELOPMENTAL BIOLOGY

Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain

(2013) Cesar Moreno et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice

(2013) R. Satpute et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma

(2013) Andrew R. Tsen et al.   INTERNATIONAL JOURNAL OF CANCER

N-Acetylaspartate (NAA) andN-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells

(2013) Patrick M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

(2013) Gisele Agustini Lovatel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis

(2013) Dhaval P. Bhatt et al.   NEUROCHEMISTRY INTERNATIONAL

A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan

(2013) Mayumi Hachinohe et al.   PLoS One

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

(2013) Clare B. Edwards et al.   PLoS One

Fasting Launches CRTC to Facilitate Long-Term Memory Formation in Drosophila

(2013) Y. Hirano et al.   SCIENCE

Effects of aging, antiaging calorie restriction and in vivo stimulation of autophagy on the urinary excretion of 8OHdG in male Sprague–Dawley rats

(2012) Alessio Donati et al.   AGE

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases

(2012) Peter W. Stacpoole   AGING CELL

Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders

(2012) Mithilesh Kumar Jha et al.   Current Neuropharmacology

A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice

(2012) Shireesh Srivastava et al.   IUBMB LIFE

HIF1α Protein Stability Is Increased by Acetylation at Lysine 709

(2012) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

(2012) Mahmoud L Soliman et al.   Journal of Neuroinflammation

Liquid Chromatography–Mass Spectrometry-based Metabolomic Analysis of Livers from Aged Rats

(2012) Nari Son et al.   JOURNAL OF PROTEOME RESEARCH

Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice

(2012) Sarah Hempenstall et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium

(2012) Helena Orozco et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Histone Acetylation Regulates Intracellular pH

(2012) Matthew A. McBrian et al.   MOLECULAR CELL

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging

(2012) Inês Tomás Pereira et al.   NEUROBIOLOGY OF AGING

Energy depletion in seizures: Anaplerosis as a strategy for future therapies

(2012) Stjepana Kovac et al.   NEUROPHARMACOLOGY

Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus

(2012) James F. Castellano et al.   PLoS One

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

(2012) Kangling Zhang et al.   PROTEOMICS

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

(2012) Wei-Chung Chiang et al.   PLoS Genetics

Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

(2012) Seung-Hyun Hong et al.   PLoS Genetics

The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction

(2011) Robin K. Minor et al.   AGING CELL

Overexpression of the PHO84 gene causes heavy metal accumulation and induces Ire1p-dependent unfolded protein response in Saccharomyces cerevisiae cells

(2011) Augustin Minel Ofiteru et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms

(2011) Xiaokun Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Real-Time Imaging of Histone H4K12–Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors

(2011) Tamaki Ito et al.   CHEMISTRY & BIOLOGY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Labeled Acetate as a Marker of Astrocytic Metabolism

(2011) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation

(2011) Chris J. Reisenauer et al.   JOURNAL OF NEUROCHEMISTRY

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

(2011) Mahmoud L. Soliman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice

(2011) Silvia Ferretti et al.   PEPTIDES

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus

(2011) Hiromasa Funato et al.   PLoS One

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation

(2011) Hai Zhang et al.   PLOS BIOLOGY

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

(2011) Sri Devi Narasimhan et al.   PLoS Genetics

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Biological significance of protein modifications in aging and calorie restriction

(2010) Akihiro Nakamura et al.   Annals of the New York Academy of Sciences

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Intracoronary pyruvate in cardiogenic shock as an adjunctive therapy to catecholamines and intra-aortic balloon pump shows beneficial effects on hemodynamics

(2010) Wolfgang Schillinger et al.   Clinical Research in Cardiology

Hypothalamic Responses to Fasting Indicate Metabolic Reprogramming Away from Glycolysis Toward Lipid Oxidation

(2010) Michal M. Poplawski et al.   ENDOCRINOLOGY

Chromatin structure as a mediator of aging

(2010) Jason Feser et al.   FEBS LETTERS

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain

(2010) Prasanth S. Ariyannur et al.   JOURNAL OF COMPARATIVE NEUROLOGY

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

(2010) A. Satoh et al.   JOURNAL OF NEUROSCIENCE

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

(2010) Andrezza Sossai Rodrigues Carvalho et al.   NEUROCHEMISTRY INTERNATIONAL

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

(2010) A. Caccamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor

(2010) Y. Popova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxicity and the Contrasting Effects of Oxaloacetate and Glycerol on Caenorhabditis elegans Life Span: A Role for Methylglyoxal?

(2010) Alan R. Hipkiss   REJUVENATION RESEARCH

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Histone H4 Acetylation is Essential to Proceed from a Histone- to a Protamine-based Chromatin Structure in Spermatid Nuclei ofDrosophila melanogaster

(2010) Stephan Awe et al.   Systems Biology in Reproductive Medicine

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

(2010) A Lanzillotta et al.   Cell Death & Disease

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

The lifespan-promoting effect of acetic acid and Reishi polysaccharide

(2009) Ming-Hong Chuang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing

(2009) F. Tie et al.   DEVELOPMENT

Lifespan extension by suppression of autophagy genes inCaenorhabditis elegans

(2009) Yasufumi Hashimoto et al.   GENES TO CELLS

Collaboration Between the Essential Esa1 Acetyltransferase and the Rpd3 Deacetylase Is Mediated by H4K12 Histone Acetylation in Saccharomyces cerevisiae

(2009) C. S. Chang et al.   GENETICS

The mitochondrial citrate carrier: Metabolic role and regulation of its activity and expression

(2009) Gabriele V. Gnoni et al.   IUBMB LIFE

GCN5-mediated Transcriptional Control of the Metabolic Coactivator PGC-1β through Lysine Acetylation

(2009) Timothy J. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury

(2009) Peethambaran Arun et al.   JOURNAL OF NEUROTRAUMA

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

(2009) Sara Connaughton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

(2009) Hongxia Shen et al.   NEUROBIOLOGY OF DISEASE

A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA

(2009) R. Magnus N. Friis et al.   NUCLEIC ACIDS RESEARCH

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

(2009) Minhua Zhang et al.   PLOS BIOLOGY

O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?

(2008) MeiShiue Kuo et al.   BIOCHIMIE

Age-related difference of site-specific histone modifications in rat liver

(2008) Kyojiro Kawakami et al.   BIOGERONTOLOGY

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function

(2008) Ling Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes

(2008) C. R. Brown et al.   GENES & DEVELOPMENT

Regulators of Cellular Levels of Histone Acetylation in Saccharomyces cerevisiae

(2008) W. Peng et al.   GENETICS

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR-Based Metabonomic Investigations into the Metabolic Profile of the Senescence-Accelerated Mouse

(2008) Ning Jiang et al.   JOURNAL OF PROTEOME RESEARCH

Chaperone Control of the Activity and Specificity of the Histone H3 Acetyltransferase Rtt109

(2008) J. Fillingham et al.   MOLECULAR AND CELLULAR BIOLOGY

Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction

(2008) Robin K. Minor et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Epigenetic memory loss in aging oligodendrocytes in the corpus callosum

(2006) Siming Shen et al.   NEUROBIOLOGY OF AGING