Ketone bodies mimic the life span extending properties of caloric restriction

Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training

(2016) Leslie A. Consitt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

(2016) Pete J. Cox et al.   Cell Metabolism

β-Hydroxybutyrate: A signaling metabolite in starvation response?

(2016) Pedro Rojas-Morales et al.   CELLULAR SIGNALLING

Novel ketone diet enhances physical and cognitive performance

(2016) Andrew J. Murray et al.   FASEB JOURNAL

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats

(2016) Jignesh D. Pandya et al.   NEUROBIOLOGY OF AGING

G6PD protects from oxidative damage and improves healthspan in mice

(2016) Sandrina Nóbrega-Pereira et al.   Nature Communications

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

(2015) Mary T. Newport et al.   Alzheimers & Dementia

Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism

(2015) Chiao-nan (Joyce) Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Overexpression of malic enzyme in the larval stage extends Drosophila lifespan

(2015) Gye-Hyeong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression

(2015) P. Charitou et al.   EMBO REPORTS

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

(2015) N. Makino et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons

(2015) Lucy Camberos-Luna et al.   NEUROCHEMICAL RESEARCH

D-ß-hydroxybutyrate: an anti-aging ketone body

(2015) Clare Edwards et al.   Oncotarget

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat

(2013) Richard L. Veech   Annals of the New York Academy of Sciences

Caloric restriction and its mimetics

(2013) Shin-Hae Lee et al.   BMB Reports

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TOR links starvation responses to telomere length maintenance

(2012) Martin Kupiec et al.   CELL CYCLE

Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet

(2012) Shireesh Srivastava et al.   FASEB JOURNAL

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ

(2012) Ja Hee Lee et al.   PLoS One

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

(2011) Sri Devi Narasimhan et al.   PLoS Genetics

β-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle

(2010) Takashi Yamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

A Ketone Ester Diet Increases Brain Malonyl-CoA and Uncoupling Proteins 4 and 5 while Decreasing Food Intake in the Normal Wistar Rat

(2010) Yoshihiro Kashiwaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

(2009) Edward J. Masoro   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

(2009) P. A. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span ofDrosophila melanogaster

(2008) Susan K. Legan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged Fasting Induces Peripheral Insulin Resistance, Which Is Not Ameliorated by High-Dose Salicylate

(2007) Saskia N. van der Crabben et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM