Article
Agriculture, Multidisciplinary
Rongying Xu, Ni Feng, Qiuke Li, Hongyu Wang, Yong Su, Weiyun Zhu
Summary: The interaction between pectin and gut microbiota is crucial for maintaining animal and human health, and this study investigated the impact of pectin supplementation on substrate dynamics and gut microbiota in a fistula pig model. The results showed that pectin supplementation decreased the concentrations of starch, cellulose, and butyrate in feces but not in the terminal ileum. Metagenomic sequencing revealed changes in the microbial composition and the enrichment of plant polysaccharide-degrading genera in feces. The findings suggest that pectin promotes complex carbohydrate substrate degradation in the hindgut through modulation of the gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Bo Zhang, Yuzhou Wan, Xuefeng Zhou, Haojun Zhang, Hailing Zhao, Liang Ma, Xi Dong, Meihua Yan, Tingting Zhao, Ping Li
Summary: This study investigated the relationship between serum metabolites and gut microbiota in the progression of diabetic kidney disease (DKD). The results showed significant alterations in serum metabolites and the composition and function of gut microbiota in DKD. The study also identified potential metabolic and microbial targets for the treatment of DKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Cassandre Bedu-Ferrari, Paul Biscarrat, Philippe Langella, Claire Cherbuy
Summary: This review highlights the importance of the gut microbiota in human health and diseases, and discusses dietary strategies, particularly the use of prebiotics, to modulate microbial composition and metabolic function. It provides insights into the concept of prebiotics, their sources and breakdown mechanisms, and explores the potential of prebiotics in metabolic diseases and personalized responses.
Review
Biology
Lijuan Fan, Yaoyao Xia, Youxia Wang, Dandan Han, Yanli Liu, Jiahuan Li, Jie Fu, Leli Wang, Zhending Gan, Bingnan Liu, Jian Fu, Congrui Zhu, Zhenhua Wu, Jinbiao Zhao, Hui Han, Hao Wu, Yiwen He, Yulong Tang, Qingzhuo Zhang, Yibin Wang, Fan Zhang, Xin Zong, Jie Yin, Xihong Zhou, Xiaojun Yang, Junjun Wang, Yulong Yin, Wenkai Ren
Summary: Dietary nutrients and the gut microbiota have a reciprocal relationship that affects the host's health and immune-mediated diseases. This review explores how this interaction influences the host's immunity and highlights the potential of gut microbiota-targeted dietary interventions in immune-associated diseases.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Einar Ringo, Ramasamy Harikrishnan, Mehdi Soltani, Koushik Ghosh
Summary: The gastrointestinal microbiota and probiotics have a significant impact on the health of fish and shellfish, influencing lipid, carbohydrate, and protein metabolism. Current research shows that probiotics can improve nutrient absorption, immune response, and stress resistance in fish, but more studies are needed.
Article
Immunology
Fang Xie, Hang-Fei Xu, Jing Zhang, Xiao-Ni Liu, Bu-Xin Kou, Meng-Yin Cai, Jing Wu, Jin-Ling Dong, Qing-Hua Meng, Yi Wang, Dexi Chen, Yang Zhang
Summary: ASPP2 deficiency promotes NAFLD progression, alters fatty acid metabolism, and causes gut microbiota dysbiosis. EPA, a long-chain fatty acid, is significantly negatively correlated with the abundance of Bifidobacterium, a specific feature of NAFLD in ASPP2-deficient mice. The results provide evidence for the mechanism of ASPP2 in dysregulation of fatty acid metabolism and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Xia Meng, Hongchen Wu, Jiayi Xiong, Yongquan Li, Lin Chen, Qing Gu, Ping Li
Summary: This study investigated the intestinal metabolism of eriocitrin and the regulation of dietary intervention on gut microbiota. A total of 136 flavonoids were found in the colon, including eriocitrin and its metabolites. Dietary intervention of eriocitrin significantly altered the gut microbiota and increased the production of short-chain fatty acids. The study provides preliminary evidence for the potential use of eriocitrin in food and biomedical applications.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cameron G. McCarthy, Emily W. Waigi, Beng San Yeoh, Blair Mell, Matam Vijay-Kumar, Camilla F. Wenceslau, Bina Joe
Summary: This study demonstrates that a low dose (5%) of 1,3-butanediol (1,3-BD) is sufficient to reverse age-related vascular dysfunction, independent of the biosynthesis of the ketone body beta-hydroxybutyrate (beta HB). These findings suggest that low-dose 1,3-BD could be a novel therapeutic approach to increase blood flow and improve the quality of life in the elderly.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Microbiology
Lars J. Lindstad, Galiana Lo, Shaun Leivers, Zijia Lu, Leszek Michalak, Gabriel V. Pereira, Asmund K. Rohr, Eric C. Martens, Lauren S. McKee, Petra Louis, Sylvia H. Duncan, Bjorge Westereng, Phillip B. Pope, Sabina Leanti La Rosa
Summary: The study demonstrates that the dominant butyrate producer Faecalibacterium prausnitzii in the human gut is able to acquire and degrade various beta-mannooligosaccharides, contributing to a more comprehensive understanding of beta-mannan metabolism and the cross-feeding interactions between beneficial microbes in the human gut. The findings highlight the importance of microbial metabolism of beta-mannans/beta-MOS as a common dietary component, offering potential insights for developing dietary formulations that may boost this beneficial symbiont and butyrate production in the gut.
Article
Biochemistry & Molecular Biology
Hiromi Sato, Shintaro Narita, Masanori Ishida, Yoshiko Takahashi, Huang Mingguo, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Toshiaki Yoshioka, Tomonori Habuchi
Summary: A diet rich in lard increases the risk of prostate cancer development and progression. Two mouse models fed with lard-enriched diets showed enhanced prostate cancer progression and weight gain compared to a fish oil diet. The composition of gut microbiota differed significantly between the two diets, with changes in bacterial species such as Clostridiales and Lactobacillales. The proportion of Lactobacillales in the gut was negatively associated with weight gain and prostate cancer progression. The study also identified genes involved in lipid metabolism and cholesterol biosynthesis that correlated with the abundance of Lactobacillales in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Haize Ge, Wei Wei, Liang Tang, Yaqiong Tian, Yu Zhu, Yan Luo, Shuye Liu
Summary: This study analyzed the characteristics of gut microbiota in patients with nonalcoholic fatty liver disease (NAFLD) and found significant changes in microbial diversity and the Bacteroides/Firmicutes ratio. The study also revealed a significant association between gut microbiota and amino acid, glucose, and lipid metabolism through phenotypic prediction and metabolite analysis. Receiver operating characteristic curve analysis showed that a combination of Bacteroides and the BF ratio had good diagnostic accuracy for NAFLD. Metabolomics and bioinformatics analysis revealed changes in metabolism and related signaling pathways in NAFLD patients.
Review
Gastroenterology & Hepatology
Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Karkkainen, Sophie Laye, Nathalie Delzenne, Kati Hanhineva
Summary: Alterations in gut microbiota composition have been linked to various neurological disorders, and the gut-brain axis plays a crucial role in this communication. While the specific mechanisms are not fully understood, existing data suggests that metabolites from gut microbiota may be key factors in the gut-brain axis communication. Further research is needed to understand the molecular mechanisms and explore intervention approaches for prevention and treatment of neurological disorders.
Article
Medicine, General & Internal
Xiaomin Yu, Qingyun Zheng, Yun He, Dandan Yu, Guolin Chang, Cheng Chen, Laixi Bi, Jia Lv, Misheng Zhao, Xiangyang Lin, Liqing Zhu
Summary: This study revealed a relationship between gut microbiota and fatty metabolism in immune thrombocytopenia (ITP). Gut microbiota may participate in the pathogenesis of ITP through affecting cytokine secretion and interfering with fatty metabolism.
FRONTIERS IN MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jie Ma, Yehui Duan, Rui Li, Xiaoxiao Liang, Tiejun Li, Xingguo Huang, Yulong Yin, Jie Yin
Summary: A comparison of lipid metabolism and microbial profiles between Shaziling pigs and Yorkshire pigs revealed significant differences in liver lipids, lipid-related gene expressions, microbial diversity, and beneficial bacteria abundance. The study also identified differentiated metabolites in the mucosa and their correlation with microbial species, highlighting the role of gut microbiota in host metabolism. Additionally, the enrichment of Lactobacillus johnsonii in Shaziling pigs was found to promote lipid metabolism and obesity in Duroc x Landrace x Yorkshire (DLY) pigs, providing a novel approach to enhance fat content in lean pigs.
Review
Biochemistry & Molecular Biology
Benedikt Golisch, Zhenhuan Lei, Kazune Tamura, Harry Brumer
Summary: Beta-glucans are a diverse group of polysaccharides that impact the composition and metabolism of the human gut microbiota, particularly through the action of polysaccharide utilization loci (PULs) responsible for saccharification. These PULs serve as important biomarkers for predicting the metabolic capability of gut bacteria in utilizing beta-glucans.
ACS CHEMICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katsumi Iizuka
Summary: Carbohydrate intake is nonlinearly associated with mortality, with high-fructose corn syrup (HFCS) consumption positively linked to obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Understanding the role of carbohydrate response element binding protein (ChREBP) in glucose and lipid metabolism is crucial in elucidating the harmful effects of HFCS, as ChREBP regulates gene expression and affects metabolites necessary for activation and de novo lipogenesis. ChREBP also plays a role in regulating fructose absorption and catabolism, and its activity partly mimics the effects of carbohydrate, particularly HFCS, on diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Nutrition & Dietetics
Katsumi Iizuka
Article
Endocrinology & Metabolism
Akira Sumida, Katsumi Iizuka, Takehiro Kato, Yanyan Liu, Sodai Kubota, Saki Kubota-Okamoto, Teruaki Sakurai, Toshinori Imaizumi, Yoshihiro Takahashi, Masami Mizuno, Ken Takao, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Mayumi Yamamoto, Yusuke Seino, Atsushi Suzuki, Daisuke Yabe
Summary: This article reports a case of a 16-year-old female with FHH, in whom genetic testing identified a calcium-sensing receptor mutation, allowing for a definitive diagnosis of FHH type 1. Family history of hypercalcemia and genetic testing are beneficial in distinguishing asymptomatic primary hyperparathyroidism from FHH.
BMC ENDOCRINE DISORDERS
(2022)
Article
Medicine, General & Internal
Daichi Tsukada, Katsumi Iizuka, Ken Takao, Yanyan Liu, Sodai Kubota, Saki Okamoto-Kubota, Toshinori Imaizumi, Teruaki Sakurai, Mayu Sakai, Takehiro Kato, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Mayumi Yamamoto, Sumihisa Kubota, Daisuke Yabe
Summary: A 22-year-old woman with Graves' disease and thymic hyperplasia was successfully treated with thiamazole. Thyroid tests and MRI confirmed the diagnoses, and the patient's thyroid function and thymic size improved after treatment. The correlation between TRAb titers and thymic size suggested a potential link between autoimmunity and thymic hyperplasia.
Review
Nutrition & Dietetics
Katsumi Iizuka
Summary: Artificial sweeteners may have no effect on body weight and glycemic control, and may even affect glucose absorption, insulin and incretin secretion in the intestine. Intake of artificial sweeteners may also alter the composition of microbiota and worsen glycemic control. Therefore, caution should be exercised when using artificial sweeteners in the treatment of diabetes and obesity.
Article
Nutrition & Dietetics
Katsumi Iizuka, Takuma Ishihara, Mayuka Watanabe, Akemi Ito, Masayoshi Sarai, Ryoji Miyahara, Atsushi Suzuki, Eiichi Saitoh, Hitomi Sasaki
Summary: The accuracy of mobile food records depends on the type of meal, and different applications may yield different results when assessing the nutritional composition of different types of meals.
Editorial Material
Endocrinology & Metabolism
Katsumi Iizuka
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Katsumi Iizuka, Daisuke Yabe, Mohamed Abu-Farha, Jehad Abubaker, Fahd Al-Mulla
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Mohamed Abu-Farha, Katsumi Iizuka, Daisuke Yabe, Fahd Al-Mulla, Jehad Abubaker
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shinji Ueno, Yusuke Seino, Shihomi Hidaka, Masashi Nakatani, Keisuke Hitachi, Naoya Murao, Yasuhiro Maeda, Haruki Fujisawa, Megumi Shibata, Takeshi Takayanagi, Katsumi Iizuka, Daisuke Yabe, Yoshihisa Sugimura, Kunihiro Tsuchida, Yoshitaka Hayashi, Atsushi Suzuki
Summary: This study investigated the effect of blockade of glucagon action on skeletal muscle using GCGKO mice. The results showed that blockade of glucagon action increased skeletal muscle weight and stimulated slow-to-fast transition in type II fibers, resembling the phenotype of a high-protein diet.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Nutrition & Dietetics
Katsumi Iizuka
Summary: Excess fructose intake is associated with various health issues. It was previously believed that fructose is primarily metabolized in the liver, but recent studies have shown the importance of small intestine metabolism in fructose processing. The carbohydrate response element-binding protein plays a regulatory role in fructose metabolism, and the polyol pathway is also involved in endogenous fructose production.
Article
Nutrition & Dietetics
Katsumi Iizuka, Hiroko Sato, Kazuko Kobae, Kotone Yanagi, Yoshiko Yamada, Chihiro Ushiroda, Konomi Hirano, Satomi Ichimaru, Yusuke Seino, Akemi Ito, Atsushi Suzuki, Eiichi Saitoh, Hiroyuki Naruse
Summary: Undernutrition among young women at Cinderella weight is socially important in Japan. In a cross-sectional study of employees aged 20-39, it was found that the percentage of underweight women was much higher than men. Further analysis showed that underweight women had lower handgrip strength, cholesterol level, and lymphocyte count compared to overweight women. Additionally, dietary characteristics revealed that many underweight women skipped breakfast and had low dietary diversity scores, as well as inadequate intake of energy, carbohydrates, fiber, calcium, and iron. Deficiencies in vitamin B-1, B-12, D, and folate were also prevalent among these women. Therefore, young underweight women may be prone to malnutrition.
Editorial Material
Nutrition & Dietetics
Katsumi Iizuka, Daisuke Yabe
Article
Endocrinology & Metabolism
Nao Nomura, Katsumi Iizuka, Eiichi Goshima, Kazuyoshi Hosomichi, Atsushi Tajima, Sodai Kubota, Yanyan Liu, Ken Takao, Takehiro Kato, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Daisuke Yabe
Summary: This article discusses the diagnosis and treatment of GCK-MODY (also known as MODY2). The authors report a case of a girl who was found to carry a GCK gene mutation through genetic testing. The patients with this condition can adequately control their blood glucose levels, thus early and accurate diagnosis is important to avoid unnecessary medication.
Article
Endocrinology & Metabolism
Shunsuke Tominari, Megumi Yasuda, Takehiro Kato, Mayu Sakai, Sodai Kubota, Kenta Nonomura, Tokuyuki Hirose, Ken Takao, Yanyan Liu, Masami Mizuno, Takuo Hirota, Katsumi Iizuka, Tetsuya Suwa, Yukio Horikawa, Daisuke Yabe
Summary: This case study presents a 92-year-old female admitted to the hospital with severe coma and abnormal levels of blood glucose and anti-diabetic medications. It highlights the importance of carefully selecting anti-diabetes drugs based on each patient's cognitive function and ADL, and sharing the rationale with general practitioners to avoid severe hypoglycemic events.
DIABETOLOGY INTERNATIONAL
(2022)