Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Metabolic Profiling Strategy ofCaenorhabditis elegansby Whole-Organism Nuclear Magnetic Resonance

(2009) Benjamin J. Blaise et al.   JOURNAL OF PROTEOME RESEARCH

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Tumours with PI3K activation are resistant to dietary restriction

(2009) Nada Y. Kalaany et al.   NATURE

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

(2009) William Mair et al.   PLoS One

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

(2008) Katherine A. Steinkraus et al.   AGING CELL

A multi-metabolite analysis of serum by 1 H NMR spectroscopy: Early systemic signs of Alzheimer’s disease

(2008) Taru Tukiainen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism inCaenorhabditis elegans

(2008) Natascha Castelein et al.   Biotechnology Journal

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

(2008) Erica D Smith et al.   BMC DEVELOPMENTAL BIOLOGY

gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans

(2008) B. J. Kemp et al.   GENETICS

A Novel Role for the SMG-1 Kinase in Lifespan and Oxidative Stress Resistance in Caenorhabditis elegans

(2008) Ingrid Masse et al.   PLoS One

A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth

(2008) M. Ralser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY