Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Metformin, an Old Drug, Brings a New Era to Cancer Therapy

(2015) Huan He et al.   CANCER JOURNAL

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest

(2015) Patrick M. Long et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The effect of statins on cancer cells—review

(2015) Lucyna Matusewicz et al.   TUMOR BIOLOGY

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

(2015) Rui Chen et al.   PLoS One

The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model

(2015) Eric C. Woolf et al.   PLoS One

Lysine-specific modifications of p53: a matter of life and death?

(2015) Diana Marouco et al.   Oncotarget

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

(2014) A.M. Poff et al.   INTERNATIONAL JOURNAL OF CANCER

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

The ketogenic diet for the treatment of malignant glioma

(2014) Eric C. Woolf et al.   JOURNAL OF LIPID RESEARCH

Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A2A receptor levels in rats subjected to neuroinflammation

(2014) Mark D Smith et al.   Journal of Neuroinflammation

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

An acetate switch regulates stress erythropoiesis

(2014) Min Xu et al.   NATURE MEDICINE

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

(2014) Bryan G. Allen et al.   Redox Biology

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

(2013) Kathryn E. Hopperton et al.   EXPERIMENTAL CELL RESEARCH

Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma

(2013) Andrew R. Tsen et al.   INTERNATIONAL JOURNAL OF CANCER

N-Acetylaspartate (NAA) andN-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells

(2013) Patrick M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux

(2013) Jing Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis

(2013) Dhaval P. Bhatt et al.   NEUROCHEMISTRY INTERNATIONAL

Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

(2013) Patrick M. Long et al.   PLoS One

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release

(2013) C Marques et al.   Cell Death & Disease

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

(2012) G. J. Kitange et al.   CLINICAL CANCER RESEARCH

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis

(2012) Catherine A Brissette et al.   Journal of Neuroinflammation

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

(2012) Mahmoud L Soliman et al.   Journal of Neuroinflammation

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice

(2012) Caroline Rae et al.   NEUROCHEMICAL RESEARCH

ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents

(2012) Xu-Yu Zu et al.   Recent Patents on Anti-Cancer Drug Discovery

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Sirtuins, Metabolism, and Cancer

(2012) Barbara Martinez-Pastor et al.   Frontiers in Pharmacology

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

(2011) Gabriele D Maurer et al.   BMC CANCER

Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation

(2011) Chris J. Reisenauer et al.   JOURNAL OF NEUROCHEMISTRY

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

(2011) Mahmoud L. Soliman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

A safety trial of high dose glyceryl triacetate for Canavan disease

(2011) Reeval Segel et al.   MOLECULAR GENETICS AND METABOLISM

Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial

(2011) Melanie Schmidt et al.   Nutrition & Metabolism

Metabolic management of brain cancer

(2010) Thomas N. Seyfried et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain

(2010) Prasanth S. Ariyannur et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease

(2010) Peethambaran Arun et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

(2010) Giulio Zuccoli et al.   Nutrition & Metabolism

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism

(2009) Yukie Yoshii et al.   CANCER SCIENCE

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

(2009) Iori Sakakibara et al.   Cell Metabolism

Glyceryl triacetate for Canavan disease: A low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model

(2009) C. N. Madhavarao et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury

(2009) Peethambaran Arun et al.   JOURNAL OF NEUROTRAUMA

The Importance of Acetyl Coenzyme A Synthetase for 11C-Acetate Uptake and Cell Survival in Hepatocellular Carcinoma

(2009) M. Yun et al.   JOURNAL OF NUCLEAR MEDICINE

Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET

(2009) Yukie Yoshii et al.   NUCLEAR MEDICINE AND BIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS