Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance

Neonatal nutritional programming impairs adiponectin effects on energy homeostasis in adult life of male rats

(2018) Mariana Peduti Halah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The effect of glucagon-like peptide 1 and glucagon-like peptide 1 receptor agonists on energy expenditure: A systematic review and meta-analysis

(2018) Michel Garcia Maciel et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system

(2018) Baile Wang et al.   EMBO REPORTS

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat

(2018) Shiki Okamoto et al.   Cell Reports

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

(2018) Sandra Galic et al.   eLife

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

(2018) Gina Cavaliere et al.   Frontiers in Physiology

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

(2018) Shin J. Lee et al.   Molecular Metabolism

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

(2018) Patricia Seoane-Collazo et al.   DIABETES

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression

(2018) Sarah Nicolas et al.   Translational Psychiatry

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

(2018) Ismael González-García et al.   Cell Reports

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

(2017) Valérie Turcot et al.   NATURE GENETICS

Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus

(2017) Shigetomo Suyama et al.   NEUROPEPTIDES

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance

(2016) Yacir Benomar et al.   DIABETES

Thyroid hormones induce browning of white fat

(2016) Noelia Martínez-Sánchez et al.   JOURNAL OF ENDOCRINOLOGY

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT

(2016) Cristina Contreras et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

(2016) Dong Kong et al.   NEURON

Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity

(2016) Edward Milbank et al.   PHARMACOLOGY & THERAPEUTICS

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

(2016) Biplab Dasgupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adiponectin, the past two decades

(2016) Zhao V. Wang et al.   Journal of Molecular Cell Biology

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

(2016) Luís Martins et al.   Cell Reports

Hypothalamic AMPK as a Regulator of Energy Homeostasis

(2016) My Khanh Q. Huynh et al.   NEURAL PLASTICITY

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

(2016) Jia Sun et al.   Molecular Metabolism

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

(2016) Mayte Alvarez-Crespo et al.   Molecular Metabolism

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

(2016) Jonathan F. Gill et al.   Molecular Metabolism

Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

(2016) Shinji Kume et al.   EBioMedicine

Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients

(2016) Evie P. M. Broeders et al.   PLoS One

Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

(2016) Shigetomo Suyama et al.   Scientific Reports

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

(2015) Kristin I. Stanford et al.   DIABETES

Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

(2015) Sander Kooijman et al.   DIABETOLOGIA

Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway

(2015) P G F Quaresma et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle

(2014) Rudy J. Valentine et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats

(2014) Sunmin Park et al.   BRAIN RESEARCH BULLETIN

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Insulin Resistance in Brain and Possible Therapeutic Approaches

(2014) Sevki Cetinkalp et al.   Current Vascular Pharmacology

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

(2014) Pengpeng Bi et al.   NATURE MEDICINE

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

(2013) Melissa A. Burmeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin

(2013) Kenneth K.Y. Cheng et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?

(2013) Stefan Trapp et al.   CURRENT OPINION IN PHARMACOLOGY

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei

(2013) Su Gao et al.   PHYSIOLOGY & BEHAVIOR

Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation

(2013) Mamoru Tanida et al.   PLoS One

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

(2013) Marcelo O. Dietrich et al.   TRENDS IN NEUROSCIENCES

miR-133a Regulates Adipocyte Browning In Vivo

(2013) Weiyi Liu et al.   PLoS Genetics

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

(2013) Hayley M. O'Neill   Diabetes & Metabolism Journal

Possible involvement of melanocortin-4-receptor and AMP-activated protein kinase in the interaction of glucagon-like peptide-1 and leptin on feeding in rats

(2012) Paul-Emile Poleni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

(2012) W. Shao et al.   DIABETES

From white to brown fat through the PGC-1 -dependent myokine irisin: implications for diabetes and obesity

(2012) J. I. Castillo-Quan   Disease Models & Mechanisms

Regulation of AMP-activated Protein Kinase Signaling by AFF4 Protein, Member of AF4 (ALL1-fused Gene from Chromosome 4) Family of Transcription Factors, in Hypothalamic Neurons

(2012) Tadasuke Komori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism

(2012) Chung Thong Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucagon-Like Peptide 1 (GLP-1) Can Reverse AMP-Activated Protein Kinase (AMPK) and S6 Kinase (P70S6K) Activities Induced by Fluctuations in Glucose Levels in Hypothalamic Areas Involved in Feeding Behaviour

(2012) Verónica Hurtado-Carneiro et al.   MOLECULAR NEUROBIOLOGY

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

(2012) Kenneth R. Watterson et al.   NEUROSIGNALS

Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats

(2011) Carina S. Solon et al.   AMINO ACIDS

AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin

(2011) Izabella Klein et al.   BRAIN RESEARCH

Adiponectin receptor signalling in the brain

(2011) John Thundyil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells

(2011) Junyu Ning et al.   ENDOCRINOLOGY

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissuein Vivo

(2011) Thomas Pulinilkunnil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

(2011) Jong-Woo Sohn et al.   NEURON

Central mechanisms involved in the orexigenic actions of ghrelin

(2011) Zane B. Andrews   PEPTIDES

Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation

(2011) Diana L. Williams et al.   PHYSIOLOGY & BEHAVIOR

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

(2010) Martin Voss et al.   CELLULAR SIGNALLING

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

(2010) C. S. Yang et al.   DIABETES

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

CNS-targets in control of energy and glucose homeostasis

(2009) André Kleinridders et al.   CURRENT OPINION IN PHARMACOLOGY

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

(2008) Sanghee SEO et al.   ENDOCRINE JOURNAL

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

(2008) Andressa Coope et al.   FEBS LETTERS

Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons

(2008) E Guillod-Maximin et al.   JOURNAL OF ENDOCRINOLOGY

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

(2007) Daisuke Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS