High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Energy-dissipating hub in muscle mitochondria: Potassium channels and uncoupling proteins

(2019) Wieslawa Jarmuszkiewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

(2019) Domenico Sergi et al.   Frontiers in Physiology

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

A photostable fluorescent marker for the superresolution live imaging of the dynamic structure of the mitochondrial cristae

(2019) Chenguang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase inCaenorhabditis elegans

(2018) Christin Riedinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors

(2018) Jonathan Alcántar-Fernández et al.   PLoS One

Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions

(2018) Yufei Song et al.   Scientific Reports

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans

(2018) Chen Xu et al.   Scientific Reports

Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans

(2018) Le Li et al.   Aging-US

Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model

(2017) Karina Barbosa de Queiroz et al.   PLoS One

Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

(2017) David Sebastián et al.   TRENDS IN MOLECULAR MEDICINE

Respiratory supercomplexes and the functional segmentation of the CoQ pool

(2016) Raquel Moreno-Loshuertos et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

(2016) Elizabeth Moreno-Arriola et al.   PLoS One

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans

(2016) M. L. Ladage et al.   G3-Genes Genomes Genetics

Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

(2016) Emma Svensk et al.   PLoS Genetics

High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to males

(2015) Marjorie R. Liggett et al.   Aging-US

Glucose Induces Sensitivity to Oxygen Deprivation and Modulates Insulin/IGF-1 Signaling and Lipid Biosynthesis in Caenorhabditis elegans

(2015) A. M. Garcia et al.   GENETICS

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Determinants and Functions of Mitochondrial Behavior

(2014) Katherine Labbé et al.   Annual Review of Cell and Developmental Biology

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

On ceramides, other sphingolipids and impaired glucose homeostasis

(2014) Philip J. Larsen et al.   Molecular Metabolism

The adipokine/ceramide axis: Key aspects of insulin sensitization

(2013) Jonathan Y. Xia et al.   BIOCHIMIE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

(2013) R. Ban-Ishihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

O-Linked-N-Acetylglucosamine Cycling and Insulin Signaling Are Required for the Glucose Stress Response inCaenorhabditis elegans

(2011) Michelle A. Mondoux et al.   GENETICS

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

(2011) Marco Gallo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

High glucose diets shorten lifespan ofCaenorhabditis elegansvia ectopic apoptosis induction

(2011) Shin Sik Choi   Nutrition Research and Practice

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage

(2010) J. M. Van Raamsdonk et al.   GENETICS

Mutations in Mitochondrial Complex III Uniquely Affect Complex I inCaenorhabditis elegans

(2010) Wichit Suthammarak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size

(2010) S.N. Reinke et al.   MOLECULAR GENETICS AND METABOLISM

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Proteomic analysis of mitochondria fromCaenorhabditis elegans

(2009) Jing Li et al.   PROTEOMICS

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

(2009) V. Menuz et al.   SCIENCE

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

(2008) David Hoogewijs et al.   BMC MOLECULAR BIOLOGY

An RNAi Screen for Mitochondrial Proteins Required to Maintain the Morphology of the Organelle in Caenorhabditis elegans

(2008) Ryohei Ichishita et al.   JOURNAL OF BIOCHEMISTRY

Complex I Function Is Defective in Complex IV-deficientCaenorhabditis elegans

(2008) Wichit Suthammarak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

(2008) X. Deng et al.   SCIENCE