Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin

The role of JAK/STAT signaling pathway and its inhibitors in diseases

(2020) Ping Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation

(2020) Xiao-Long Cui et al.   Nature Communications

SIRT6 participates in the quality control of aged oocytes via modulating telomere function

(2019) Juan Ge et al.   Aging-US

The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function

(2019) Doksani   Genes

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

(2019) Veverka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An update on the biology and management of dyskeratosis congenita and related telomere biology disorders

(2019) Marena R. Niewisch et al.   Expert Review of Hematology

Development of Tissue-Specific Age Predictors Using DNA Methylation Data

(2019) Choi et al.   Genes

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

(2019) Katie L. Owen et al.   Cancers

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians

(2018) Helena Stabile et al.   IMMUNOLOGICAL REVIEWS

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression

(2017) Jana Naue et al.   Forensic Science International-Genetics

Independent validation of DNA-based approaches for age prediction in blood

(2017) Sohee Cho et al.   Forensic Science International-Genetics

DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers

(2017) Sae Rom Hong et al.   Forensic Science International-Genetics

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations

(2017) Shyamalika Gopalan et al.   GENETICS

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-6, IL-8 and TNF-α levels correlate with disease stage in breast cancer patients

(2017) Yunfeng Ma et al.   Advances in Clinical and Experimental Medicine

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations

(2017) Shyamalika Gopalan et al.   GENETICS

Epigenetic Regulation of Cellular Senescence and Aging

(2017) Corinne Sidler et al.   Frontiers in Genetics

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife

(2016) Christiane Elisabeth Sørensen et al.   PLoS One

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

(2016) Madalena C. Carneiro et al.   PLoS Genetics

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

(2015) Jodie Birch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans

(2015) Byambaa Enkhmaa et al.   ATHEROSCLEROSIS

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

(2015) Eric Lieberman Greer et al.   CELL RESEARCH

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular genetics of the telomere biology disorders

(2015) Alison A. Bertuch   RNA Biology

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

(2015) Ryan R. White et al.   Nature Communications

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

(2015) Yasumichi Arai et al.   EBioMedicine

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

(2015) Tomohisa Hayakawa et al.   PLoS One

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

(2014) Francesca Rossiello et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

(2013) Elsa Vera et al.   PLoS One

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Association of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality

(2012) Lawrence S. Honig et al.   ARCHIVES OF NEUROLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

(2011) Nuno M. V. Gomes et al.   AGING CELL

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Dyskeratosis Congenita

(2011) I. Dokal   Hematology-American Society of Hematology Education Program

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY