Article
Oncology
Agnes Basseville, Pierre-Christian Violet, Maryam Safari, Carole Sourbier, W. Marston Linehan, Robert W. Robey, Mark Levine, Dan L. Sackett, Susan E. Bates
Summary: This study identifies an association between the RAS-phenotype and sensitivity to histone deacetylase inhibitors in solid tumors. The researchers found that romidepsin treatment depletes acetyl-CoA, leading to metabolic and oxidative stress and ultimately causing death in KRAS-mutant cells. Analysis also revealed a correlation between acetyl-CoA generation pathways and HDACi sensitivity.
Review
Endocrinology & Metabolism
Gonzalo Fernandez-Fuente, Michael J. Rigby, Luigi Puglielli
Summary: By regulating intracellular signaling molecules, especially the citrate/acetyl-CoA pathway, homeostatic responses in cells can be activated. The citrate/acetyl-CoA pathway plays important roles in various biological functions within cells and is associated with N epsilon-lysine acetylation. Specifically, in the acetylation machinery of the endoplasmic reticulum (ER), ER acetylation regulates metabolic communication and homeostasis between different cellular organelles, affecting cellular adaptive responses and specific disease states. Therefore, citrate and acetyl-CoA should be recognized as both metabolic substrates and important signaling molecules for cellular adaptation.
MOLECULAR METABOLISM
(2023)
Article
Chemistry, Medicinal
Flore Nardella, Ludovic Halby, Irina Dobrescu, Johanna Viluma, Corentin Bon, Aurelie Claes, Veronique Cadet-Daniel, Ambre Tafit, Camille Roesch, Elie Hammam, Diane Erdmann, Melissa Mairet-Khedim, Roger Peronet, Salah Mecheri, Benoit Witkowski, Artur Scherf, Paola B. Arimondo
Summary: The newly developed derivatives combining pan-histone deacetylase inhibitor with DNA methyltransferase inhibitor show superior activity in treating malaria and potent inhibition against human HDAC6. These compounds are fully active against multidrug-resistant Plasmodium and offer a cost-effective alternative to current failing antimalarial therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Xue-Ning Wang, Li-Li Hong, Jian-Qiang Kong
Summary: A stable acetyl-CoA-synthesizing biocatalyst was identified using maltose O-acetyltransferase (MAT) with diacerein as an acetyl donor, providing a promising and cost-effective alternative method for acetylation modifications. The mutant MAT-E125F showed the highest yield of acetyl-CoA production and could also synthesize glycosyl esters through acetylation or transesterification reactions. The multifunctional MAT displayed a potent capacity in synthesizing acetyl-CoA and glycosyl esters using diacerein as an acetyl donor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sethu C. Nair, Justin T. Munro, Alexis Mann, Manuel Llinas, Sean T. Prigge
Summary: Coenzyme A (CoA) biosynthesis is a critical target for combating malaria. The study reveals the essential role of the mitochondrion in cellular acetyl-CoA biosynthesis and identifies a synthetic lethal relationship between two key ketoacid dehydrogenase enzymes. The lipoate attachment enzyme LipL2 is found to be crucial for the activity of these enzymes, which is indispensable for parasite survival due to its involvement in acetyl-CoA metabolism. Additionally, the study highlights the importance of mitochondrial-derived acetyl-CoA for protein acetylation outside the mitochondrion. Overall, these findings underscore the significance of the mitochondrion in cellular acetyl-CoA metabolism and protein acetylation crucial for parasite survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Amel Mameri, Jacques Cote
Summary: The multisubunit NuA4/TIP60 complex is involved in various biological processes as a lysine acetyltransferase, chromatin modifying factor and gene co-activator. However, understanding of its molecular mechanisms is limited and contradictory, thus requiring further investigation. Recently, the identification of JAZF1 as a novel subunit linked to metabolic homeostasis has provided an exciting direction for exploring the role of NuA4/TIP60 in metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Abigail Schoeller, Keshav Karki, Arul Jayaraman, Robert S. Chapkin, Stephen Safe
Summary: The study found that certain dietary-derived short chain fatty acids exhibit SERD-like activity and may be beneficial for treating ER-positive endocrine resistant breast cancer patients. In addition, histone deacetylase inhibitors also showed similar mechanisms of action.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Weijing He, Qingguo Li, Xinxiang Li
Summary: Acetyl-CoA is an important molecule that participates in multiple intracellular metabolic reactions and affects protein post-translational modification, playing a key role in cell metabolism and epigenetic inheritance. In cancer, extensive lipid metabolism and histone acetylation are required for cancer cell growth and expression of cancer-promoting genes. Acetyl-CoA, as a raw material for lipid synthesis and histone acetylation, has a major impact on lipid metabolism and histone acetylation in cancer. Moreover, acetyl-CoA connects lipid metabolism with histone acetylation, forming a complex regulatory mechanism that influences cancer growth, proliferation, and metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
Michela Giuliano, Claudia Pellerito, Adriana Celesia, Tiziana Fiore, Sonia Emanuele
Summary: Organotin(IV) compounds are a class of non-platinum metallo-conjugates with antitumor properties. Among them, triorganotin(IV) butyrate (BT2) shows high efficacy in colon cancer cells by inducing G2/M cell cycle arrest, ER stress, and apoptotic cell death. Furthermore, BT2 can decrease histone acetylation levels and prevent acetylation induced by other HDAC inhibitors, suggesting its potential as an epigenetic modulator in colon cancer treatment.
Article
Chemistry, Medicinal
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel, Rossella Fioravanti, Beatrice Noce, Carola Castiello, Stefano Tomassi, Davide Corinti, Daniela Passeri, Roberto Pellicciari, Ciro Mercurio, Mario Varasi, Lucia Altucci, Marco Tripodi, Raffaele Strippoli, Angela Nebbioso, Sergio Valente, Antonello Mai
Summary: After years of research, HDAC inhibitors have been developed and approved by FDA/Chinese FDA for the treatment of cancer and non-cancer diseases. A series of novel compounds have been discovered to be effective anticancer agents, demonstrating selective inhibition of HDACs and inducing cell death and differentiation. These compounds also modulate gene and protein expression related to apoptosis and show potent antiproliferative activity in various cancer cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Monica Dominguez, Bernhard Bruene, Dmitry Namgaladze
Summary: Recent studies have shown the profound influence of metabolism on immune responses, particularly through epigenetic regulation of gene expression. ACLY plays a crucial role in the formation of cytosolic acetyl-CoA, supporting de novo lipogenesis and contributing to epigenetic regulation through histone acetylation. Alternative sources of acetyl-CoA also play a role in metabolic and epigenetic regulation in immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Patrick C. Bradshaw
Summary: Acetyl-CoA plays important roles in regulating gene expression and promoting longevity, with decreased cytoplasmic levels potentially contributing to longevity and increased nuclear levels aiding in histone acetylation and lifespan extension. Future research should focus on the role of nuclear acetyl-CoA and histone acetylation in controlling hypothalamic inflammation, a key driver of organismal aging.
Article
Oncology
Abigail Schoeller, Keshav Karki, Arul Jayaraman, Robert S. Chapkin, Stephen Safe
Summary: Early stage ER alpha-positive breast cancer patients with aggressive endocrine-resistant tumors expressing mutant forms of ER alpha can be treated with selective ER down regulators (SERDs). HDAC inhibitors and dietary short chain fatty acids (SCFAs) may have similar effects on downregulating ER alpha.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Narayanan Puthillathu Vasudevan, Dharmendra K. Soni, John R. Moffett, Jishnu K. S. Krishnan, Abhilash P. Appu, Sarani Ghoshal, Peethambaran Arun, John M. Denu, Thomas P. Flagg, Roopa Biswas, Aryan M. Namboodiri
Summary: The acetate activating enzyme Acss2 plays a role in matching cellular metabolism to current conditions and has regulatory functions in addition to its role in lipid synthesis. Using Acss2 knockout mice, this study investigated the roles of Acss2 in liver, brain, and adipose tissue and found dysregulation of numerous signaling pathways and cellular processes. The loss of Acss2 resulted in few changes in fatty acid constitution in these organ systems. Overall, this research demonstrates the organ-specific transcriptional regulatory patterns of Acss2 and its role as a regulatory enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yue Lu, Qing Bu, Mingli Chuan, Xiaoyun Cui, Yu Zhao, Dao-Xiu Zhou
Summary: Chromatin modifications play a crucial role in shaping the epigenome and regulating gene expression during plant development and adaptation to environmental changes. The activities of chromatin modification enzymes are influenced by cellular metabolites, such as S-adenosyl-methionine, acetyl-CoA, alpha-ketoglutarate, and NAD(+). On the other hand, changes in the plant epigenome and activity of epigenetic regulators can impact cellular metabolism through regulation of metabolic enzymes. This review highlights recent advances in understanding the metabolic control of plant chromatin regulators and epigenomes, which contribute to plant adaptation to environmental stresses.
Review
Obstetrics & Gynecology
Shiqin Zhu, Bingqian Zhang, Xiao Jiang, Zeyan Li, Shigang Zhao, Linlin Cui, Zi-Jiang Chen
FERTILITY AND STERILITY
(2019)
Article
Biochemistry & Molecular Biology
Dawei Wang, Qingqing Xu, Quan Yuan, Mengqi Jia, Huanmin Niu, Xiaofei Liu, Jinsan Zhang, Charles Yf Young, Huiqing Yuan
Review
Clinical Neurology
Zeyan Li, Zhiqing Fang, Naidong Xing, Shiqin Zhu, Yidong Fan
SLEEP MEDICINE REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
Shiqin Zhu, Zeyan Li, Linlin Cui, Yanli Ban, Peter C. K. Leung, Yan Li, Jinlong Ma
Summary: The study showed that integrin beta 1 mediates activin A-promoted trophoblast invasion through the ALK4-activated SMAD2/3-SMAD4 pathway. The predictive/diagnostic value of first-trimester maternal serum activin A for hypertensive disorders of pregnancy might be different in the IVF population.
Article
Cell Biology
Zeyan Li, Shuo Zhao, Shiqin Zhu, Yidong Fan
Summary: The study identified the miR-153-5p/AGO1 axis as crucial in the occurrence and progression of ccRCC tumors through the PI3K/Akt signaling pathway, providing potential therapeutic targets and prognostic biomarkers for patients with ccRCC.
CELL DEATH & DISEASE
(2021)
Review
Endocrinology & Metabolism
Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan, Yan Li
Summary: A systematic review and meta-analysis showed that women with PCOS have higher accumulations of visceral fat, abdominal subcutaneous fat, total body fat, trunk fat, and android fat compared to BMI-matched controls. However, when only studies using MRI or CT were considered, there were no significant differences in body fat distribution between PCOS and controls. Additionally, young and non-obese PCOS patients were found to be more likely to accumulate android fat.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Qingqing Xu, Zhaoyang Liu, Zhiqiang Cao, Yongjian Shi, Ning Yang, Guangshang Cao, Chunmin Zhang, Rong Sun, Chunhong Zhang
Summary: The study demonstrates the therapeutic effects of astilbin in an IMQ-induced psoriasis-like murine model. It alleviates skin lesions by promoting epidermal keratinocyte differentiation and reducing inflammatory cytokine expression. These findings support the potential clinical application of astilbin for psoriasis treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Hongyu Zhao, Rufeng Chen, Dongxue Zheng, Feng Xiong, Fan Jia, Jinyuan Liu, Lili Zhang, Nana Zhang, Shiqin Zhu, Yongmei Liu, Linhua Zhao, Xinmin Liu
Summary: This study analyzed the characteristics of the intestinal microbiota in patients with PCOS-IR and explored the mechanism of modified Banxia Xiexin Decoction in treating PCOS-IR. The results showed that PCOS-IR model had an imbalance of intestinal microbiota and Genus Clostridium_sensu_stricto_1 might be the pivotal pathogenic bacteria. Modified Banxia Xiexin Decoction can improve PCOS-IR by regulating the balance of intestinal microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tong Chen, Fan Jia, Yue Yu, Wufan Zhang, Chaoying Wang, Shiqin Zhu, Nana Zhang, Xinmin Liu
Summary: Polycystic ovary syndrome is a common disease that seriously affects women's physical and mental health. Quercetin can intervene in the pathologic process of PCOS from multiple aspects, making it significant in the treatment of PCOS.
Article
Immunology
Xiangxin Lan, Ling Guo, Shiqin Zhu, Yongzhi Cao, Yue Niu, Shuwen Han, Zeyan Li, Yan Li, Junhao Yan
Summary: Pregnancy-induced hypertension (PIH) is a common pregnancy complication that affects the mother and fetus. The incidence of PIH is higher in pregnancies conceived after assisted reproductive technology (ART) than in spontaneous pregnancies. This study found that using a cytokine profile can effectively predict the risk of PIH in ART pregnancies, providing a basis for early intervention and prevention of PIH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ling Guo, Xiangxin Lan, Shanshan Liu, Lianqiong Xu, Shiqin Zhu, Hong-jin Zhao, Jinlai Meng, Yan Li
Summary: In this study, comprehensive bioinformatic analysis and logistic regression analysis were used to compare serum cytokine profiles between normotensive pregnant subjects and PE patients. The results showed significant differences in cytokine expressions between the two groups, which had significant correlations with the clinical features of PE. A panel of nine cytokines was identified for the diagnosis of PE, and a diagnostic model constructed from these cytokines showed better performance than any individual cytokine, providing a basis for developing early clinical diagnostic and therapeutic strategies for PE.
INFLAMMATION RESEARCH
(2023)
Article
Plant Sciences
Qingqing Xu, Lisong Sheng, Xia Zhu, Zhaoyang Liu, Guo Wei, Tianyu Zhang, Hang Du, Anbo Yang, Jingchun Yao, Guimin Zhang, Rong Sun
Summary: This study evaluated the anti-psoriasis effect of Jingfang granules (JFG) and explored its mechanisms using network pharmacology, UPLC-Q-TOF-MS technology, and molecular biotechnology methods. The results showed that JFG improved psoriasis by inhibiting the maturation and activation of dendritic cells and the proliferation and inflammation of keratinocytes. This has important implications for the clinical application of JFG in antipsoriasis therapy.
Article
Infectious Diseases
Qingqing Xu, Xiaochen Wang, Anbo Yang, Guo Wei
Summary: This study aims to investigate the efficacy of tofacitinib in refractory palmoplantar pustulosis (PPP). After 4 weeks of treatment, half of the patients achieved more than 80% reduction in PPPASI, and at week 12, 83.3% of the patients had 80% reduction in PPPASI with no serious adverse events reported. Therefore, tofacitinib shows promise as a treatment for refractory PPP, but further clinical observation and research are needed.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Endocrinology & Metabolism
Nana Zhang, Yan Liao, Hongyu Zhao, Tong Chen, Fan Jia, Yue Yu, Shiqin Zhu, Chaoying Wang, Wufan Zhang, Xinmin Liu
Summary: This study used a bidirectional two-sample Mendelian randomization (MR) design to investigate the causal association between polycystic ovary syndrome (PCOS) and 25-hydroxyvitamin D (25OHD) deficiency. The findings showed a negative association between genetically determined PCOS and 25OHD levels, but this causal effect disappeared when adjusting for obesity and insulin resistance. The study failed to find a substantial causal effect of 25OHD deficiency on the risk of PCOS. Further observational studies and clinical trials are needed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
