The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
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Title
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Authors
Keywords
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Journal
Oxidative Medicine and Cellular Longevity
Volume 2021, Issue -, Pages 1-16
Publisher
Hindawi Limited
Online
2021-04-21
DOI
10.1155/2021/6635460
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Note: Only part of the references are listed.- Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2
- (2021) Ping Liu et al. Cell Death & Disease
- SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity
- (2020) Da Hyun Lee et al. Autophagy
- The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner
- (2020) Ricardo Aparicio et al. Autophagy
- Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling
- (2020) Shu-ping Li et al. Cell Communication and Signaling
- Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease�1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway
- (2020) Lei Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Aronia melanocarpa Prevents Alcohol-Induced Chronic Liver Injury via Regulation of Nrf2 Signaling in C57BL/6 Mice
- (2020) Zhuqian Wang et al. Oxidative Medicine and Cellular Longevity
- Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries
- (2020) Chaoqun Yan et al. Oxidative Medicine and Cellular Longevity
- Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway
- (2020) Meihuan Zhao et al. Frontiers in Pharmacology
- Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids
- (2020) Melania Maria Serafini et al. Frontiers in Pharmacology
- Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro‐inflammatory cytokines
- (2020) Dongsheng Shang et al. AGING CELL
- Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway
- (2020) Shuang Zhao et al. HEPATOLOGY
- Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy
- (2020) Yuanzhong Zhang et al. Oxidative Medicine and Cellular Longevity
- Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
- (2020) Fei Xu et al. Cell and Bioscience
- Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice
- (2020) Liming Lei et al. Frontiers in Pharmacology
- MicroRNA-based regulatory mechanisms underlying the synergistic antioxidant action of quercetin and catechin in H2O2-stimulated HepG2 cells: Roles of BACH1 in Nrf2-dependent pathways
- (2020) Dan Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway
- (2020) Yan Xu et al. Oxidative Medicine and Cellular Longevity
- Bacteria-derived metabolite, methylglyoxal, modulates the longevity ofC. elegansthrough TORC2/SGK-1/DAF-16 signaling
- (2020) Min-Gi Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
- (2020) Yueming Wang et al. Food Science & Nutrition
- Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway
- (2020) Tso-Ting Lai et al. Antioxidants
- Role of Nrf2 in cell senescence regulation
- (2020) Huan Yuan et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands
- (2020) Sisca Meida Wati et al. Redox Biology
- Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?
- (2020) Tharindu L. Suraweera et al. Antioxidants
- Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy
- (2020) Weiwei Zhang et al. AGEING RESEARCH REVIEWS
- Senescent cells as promising targets to tackle age-related diseases
- (2020) Eva Prašnikar et al. AGEING RESEARCH REVIEWS
- Redox regulation by NRF2 in aging and disease
- (2019) Cody J. Schmidlin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond
- (2019) Elzbieta Pawlowska et al. Oxidative Medicine and Cellular Longevity
- Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy
- (2019) Weijian Sun et al. MOLECULAR THERAPY
- Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
- (2019) Jialin Duan et al. Journal of Neuroinflammation
- Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?
- (2019) Kelvin J.A. Davies et al. FREE RADICAL BIOLOGY AND MEDICINE
- TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer
- (2019) Kautilya Kumar Jena et al. Autophagy
- Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress–induced apoptosis
- (2019) LA Méndez-García et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1
- (2019) Li Tian et al. Redox Biology
- Oxidative Stress Induced Downregulation of Glycogen Synthase kinase 3β (GSK3β) in Fetal Membranes Promotes Cellular Senescence
- (2019) Narmada Lavu et al. BIOLOGY OF REPRODUCTION
- Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
- (2019) Luca Lignitto et al. CELL
- BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
- (2019) Clotilde Wiel et al. CELL
- Thyroid hormone protects cardiomyocytes from H2O2-induced oxidative stress via the PI3K-AKT signaling pathway
- (2019) Bin Zeng et al. EXPERIMENTAL CELL RESEARCH
- TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages
- (2019) Kritika Sudan et al. FREE RADICAL BIOLOGY AND MEDICINE
- p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway
- (2019) Weitang Liao et al. FREE RADICAL RESEARCH
- Dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest
- (2019) Zhen Zhao et al. GENOMICS
- Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development
- (2019) Natalia Robledinos-Antón et al. Oxidative Medicine and Cellular Longevity
- Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production
- (2019) Ran Wei et al. Scientific Reports
- Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
- (2019) Ricardo Aparicio et al. Cell Reports
- Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
- (2019) Takafumi Suzuki et al. Cell Reports
- Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing
- (2019) Laura C.D. Pomatto et al. Redox Biology
- FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding
- (2019) Kai-Chun Cheng et al. EBioMedicine
- Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells
- (2019) Hongqiao Zhang et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence
- (2019) Gloria Salazar et al. Autophagy
- Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling
- (2019) Xiaoning Tian et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex
- (2019) Danielle da Silva Dias et al. EXPERIMENTAL GERONTOLOGY
- Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway
- (2019) Liang Jing et al. MOLECULES
- GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition
- (2019) Minglei Lu et al. Redox Biology
- A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration
- (2019) Yan Shao et al. Oxidative Medicine and Cellular Longevity
- Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
- (2019) Zhi-Xiang Xu et al. Nature Communications
- The effect of ageing on the resolution of inflammation
- (2019) Wezi Sendama AGEING RESEARCH REVIEWS
- Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability
- (2019) Liyang Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway
- (2019) Simiao Qiao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway
- (2019) Yu Zhuang et al. Oxidative Medicine and Cellular Longevity
- The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
- (2019) Caroline Kumsta et al. Nature Communications
- Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling in RPE and protects against oxidative stress-induced outer retinal degeneration
- (2019) Ravirajsinh N. Jadeja et al. Redox Biology
- The dietary triterpenoid 18α–Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway
- (2019) Maria Lefaki et al. Redox Biology
- AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride
- (2019) Chao Song et al. CHEMOSPHERE
- mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway
- (2018) Han-wei Yang et al. ACTA PHARMACOLOGICA SINICA
- Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan
- (2018) Shruti Bhide et al. AGING CELL
- Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- (2018) Eun Nim Kim et al. Aging-US
- MicroRNA-135b-5p prevents oxygen-glucose deprivation and reoxygenation-induced neuronal injury through regulation of the GSK-3/Nrf2/ARE signaling pathway
- (2018) Qiang Duan et al. Archives of Medical Science
- Activation of KGFR-Akt-mTOR-Nrf2 signaling protects human retinal pigment epithelium cells from Ultra-violet
- (2018) Haitao Hu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC
- (2018) Liang Shi et al. BIOCHEMICAL PHARMACOLOGY
- Oxidative Stress and Cancer: The Role of Nrf2
- (2018) Soraya Sajadimajd et al. CURRENT CANCER DRUG TARGETS
- Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways
- (2018) Hailong Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)
- (2018) Laura C.D. Pomatto et al. FREE RADICAL BIOLOGY AND MEDICINE
- Orientin-mediated Nrf2/HO-1 signal alleviates H 2 O 2 -induced oxidative damage via induction of JNK and PI3K/AKT activation
- (2018) Qingfei Xiao et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Genistein attenuates di‑(2‑ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO‑1 following prepubertal exposure
- (2018) Liandong Zhang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- MicroRNA-135a alleviates oxygen-glucose deprivation and reoxygenation-induced injury in neurons through regulation of GSK-3β/Nrf2 signaling
- (2018) Xiaobin Liu et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Curcumin exerts a protective effect against premature ovarian failure in mice
- (2018) Zhengjie Yan et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases
- (2018) Sathish Sundar Dhilip Kumar et al. MOLECULES
- The Role of Catechins in Cellular Responses to Oxidative Stress
- (2018) Jurga Bernatoniene et al. MOLECULES
- Autophagy as a promoter of longevity: insights from model organisms
- (2018) Malene Hansen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
- (2018) Joanna Wojsiat et al. Oxidative Medicine and Cellular Longevity
- C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
- (2018) Sharadha Dayalan Naidu et al. Scientific Reports
- Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway
- (2018) Ying Xin et al. Redox Biology
- Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells
- (2018) Lulu Zhou et al. Redox Biology
- Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
- (2018) Xiao-Juan Zhao et al. Redox Biology
- Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
- (2018) Yuguang Zhao et al. Redox Biology
- Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease
- (2018) Anthony J. Donato et al. CIRCULATION RESEARCH
- Voluntary exercise reverses immune aging induced by oxidative stress in aging mice
- (2018) Ji-Young Lee et al. EXPERIMENTAL GERONTOLOGY
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2
- (2018) Michael McMahon et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Keap1–MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa
- (2018) Nele Tamberg et al. Scientific Reports
- Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway
- (2018) Fabiana Morroni et al. Aging and Disease
- Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide
- (2018) Hua Liu et al. Cell Communication and Signaling
- Protection of Kaempferol on Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage
- (2018) Weiwei Du et al. Oxidative Medicine and Cellular Longevity
- Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2
- (2018) Shuangshuang Wei et al. BIOCHIMIE
- Flavonoids and platelet aggregation: A brief review
- (2017) Caterina Faggio et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1
- (2017) Weixia Sun et al. FREE RADICAL BIOLOGY AND MEDICINE
- Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
- (2017) Takafumi Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease
- (2017) Tahir Ali et al. MOLECULAR NEUROBIOLOGY
- Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ
- (2017) Kathrin Pallauf et al. Oxidative Medicine and Cellular Longevity
- Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice
- (2017) Ping He et al. Oxidative Medicine and Cellular Longevity
- KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
- (2017) Luisa Quinti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway
- (2017) Yan Zhang et al. REJUVENATION RESEARCH
- Modulation of telomere protection by the PI3K/AKT pathway
- (2017) Marinela Méndez-Pertuz et al. Nature Communications
- Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans
- (2017) Diletta Edifizi et al. Cell Reports
- NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
- (2017) Ana I. Rojo et al. Redox Biology
- MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells
- (2017) Suvi M. Kuosmanen et al. Scientific Reports
- 6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts
- (2017) Aimilia D. Sklirou et al. Scientific Reports
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibition
- (2016) Yue Jia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dangerous Entrapment for NRF2
- (2016) Vera Gorbunova et al. CELL
- Exercise-induced Nrf2-signaling is impaired in aging
- (2016) Aaron J. Done et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 Transcription Factor Can Directly Regulate mTOR
- (2016) Gabriel Bendavit et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
- (2016) Min Sung Joo et al. MOLECULAR AND CELLULAR BIOLOGY
- Role of ROS and RNS Sources in Physiological and Pathological Conditions
- (2016) Sergio Di Meo et al. Oxidative Medicine and Cellular Longevity
- A literature review of flavonoids and lifespan in model organisms
- (2016) Kathrin Pallauf et al. PROCEEDINGS OF THE NUTRITION SOCIETY
- 3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling
- (2016) Ke-ran Li et al. Scientific Reports
- Activation of a Novel c-Myc-miR27-Prohibitin 1 Circuitry in Cholestatic Liver Injury Inhibits Glutathione Synthesis in Mice
- (2015) Heping Yang et al. ANTIOXIDANTS & REDOX SIGNALING
- NRF2 and microRNAs: new but awaited relations
- (2015) Svitlana Kurinna et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Reduced Expression of MYC Increases Longevity and Enhances Healthspan
- (2015) Jeffrey W. Hofmann et al. CELL
- Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells
- (2015) Marcos Roberto de Oliveira et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
- (2015) Yinhang Yu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
- (2015) Ryota Saito et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models
- (2015) Danielle R. Bruns et al. Oxidative Medicine and Cellular Longevity
- Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
- (2015) Kaitlyn N. Lewis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- (2015) C. Kang et al. SCIENCE
- Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments
- (2015) Xiaohong Yang et al. ARTHRITIS RESEARCH & THERAPY
- Effect of curcumin on aging retinal pigment epithelial cells
- (2015) Jiong Lu et al. Drug Design Development and Therapy
- Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer
- (2014) Xiu-Feng Hu et al. Asian Pacific Journal of Cancer Prevention
- Inhibitory effect of 14,15-EET on endothelial senescence through activation of mTOR complex 2/Akt signaling pathways
- (2014) Cui Yang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells
- (2014) D. Larrieu et al. SCIENCE
- Nrf2 signaling is impaired in the aging RPE given an oxidative insult
- (2013) Mira M. Sachdeva et al. EXPERIMENTAL EYE RESEARCH
- Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease
- (2013) Susan A. Farr et al. FREE RADICAL BIOLOGY AND MEDICINE
- GSK-3α is a central regulator of age-related pathologies in mice
- (2013) Jibin Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- Flavonoid Bioavailability and Attempts for Bioavailability Enhancement
- (2013) Surangi Thilakarathna et al. Nutrients
- Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
- (2013) Sandhya Khurana et al. Nutrients
- Sites of reactive oxygen species generation by mitochondria oxidizing different substrates
- (2013) Casey L. Quinlan et al. Redox Biology
- The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613
- (2012) John M. Hourihan et al. ANTIOXIDANTS & REDOX SIGNALING
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
- (2012) Paul D. Ray et al. CELLULAR SIGNALLING
- Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade
- (2012) Jeongho Kwon et al. EMBO REPORTS
- Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
- (2012) Kai Takaya et al. FREE RADICAL BIOLOGY AND MEDICINE
- A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila
- (2011) Alysia Vrailas-Mortimer et al. DEVELOPMENTAL CELL
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
- (2011) Na Li et al. MECHANISMS OF AGEING AND DEVELOPMENT
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor
- (2011) C.-H. Chen et al. Science Signaling
- Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice
- (2010) Namakkal Soorappan Rajasekaran et al. ANTIOXIDANTS & REDOX SIGNALING
- Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
- (2010) Weiliang Fan et al. Autophagy
- C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements
- (2010) Smadar Levy et al. IUBMB LIFE
- Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts
- (2010) Suzanne Kapeta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
- (2010) Ian M. Copple et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
- (2009) Aimee L. Eggler et al. BIOCHEMICAL JOURNAL
- Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells
- (2009) D. Wang et al. CANCER RESEARCH
- p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
- (2009) Jorge Moscat et al. CELL
- Role of Glycogen Synthase Kinase-3β in Cardioprotection
- (2009) Magdalena Juhaszova et al. CIRCULATION RESEARCH
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- (−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
- (2008) Hye-Kyung Na et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Diet and Aging
- (2008) Matthew D.W. Piper et al. Cell Metabolism
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress
- (2008) Ana I. Rojo et al. JOURNAL OF NEUROCHEMISTRY
- Cell cycle and activation of CK2
- (2008) Miwako Kato Homma et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
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