Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

(2020) Md. Abdul Alim Al‐Bari et al.   Annals of the New York Academy of Sciences

AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

(2020) Irene Benito-Cuesta et al.   Autophagy

Targeting Hsc70-based autophagy to eliminate amyloid β oligomers

(2020) Juan Dou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microautophagy regulates proteasome homeostasis

(2020) Jianhui Li et al.   CURRENT GENETICS

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

(2020) Arjen J. Jakobi et al.   Nature Communications

Decreased ovarian function and autophagy gene methylation in aging rats

(2020) Qiuyuan Li et al.   Journal of Ovarian Research

Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles

(2020) Daniela Perroni Frias et al.   Scientific Reports

Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

(2020) Yueyang Zhao et al.   Frontiers in Aging Neuroscience

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

(2020) Nanbu Wang et al.   Frontiers in Pharmacology

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

(2020) Chandramohan Kiruthiga et al.   Cancers

Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases

(2020) Houman Kahroba et al.   BIOCHIMIE

Hippo Signaling: Autophagy Waits in the Wings

(2020) Thomas P. Neufeld   DEVELOPMENTAL CELL

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels in APPswe/PS1dE9 mice through antioxidant and anti-inflammatory pathways

(2020) Chao Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases

(2020) Frédéric Darios et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

(2020) Ekta Singh et al.   MOLECULAR BIOLOGY REPORTS

β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer's disease

(2020) Minzhen Deng et al.   Molecular Medicine Reports

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model

(2020) Siwon Kim et al.   NEUROPHARMACOLOGY

Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease

(2020) Dongsheng Ji et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dacryodes edulis (G. Don) H.J. Lam modulates glucose metabolism, cholinergic activities and Nrf2 expression, while suppressing oxidative stress and dyslipidemia in diabetic rats

(2020) Ochuko L. Erukainure et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebrafish

(2019) Azhwar Raghunath et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1–Nrf2–ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo

(2019) Jun Yan et al.   ACS Chemical Neuroscience

Curcumin analogues attenuate Aβ25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways

(2019) Jialin Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

(2019) Helmut Denk et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress

(2019) Ling Wang et al.   PLoS Pathogens

Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects

(2019) Yanqiu Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cerebrovascular and Neurological Disorders: Protective Role of NRF2

(2019) Farzane Sivandzade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orientin Improves Cognition by Enhancing Autophagosome Clearance in an Alzheimer’s Mouse Model

(2019) Yi Zhong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The neuroprotective activities of natural products through the Nrf2 upregulation

(2019) Alireza Tavakkoli et al.   PHYTOTHERAPY RESEARCH

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

(2019) Xiaokang Li et al.   Acta Pharmaceutica Sinica B

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

(2019) Lígia Fão et al.   AGEING RESEARCH REVIEWS

MnFe2O4 nanoparticles accelerate the clearance of mutant huntingtin selectively through ubiquitin-proteasome system

(2019) Li Zhang et al.   BIOMATERIALS

Emerging Screening Approaches in the Development of Nrf2–Keap1 Protein–Protein Interaction Inhibitors

(2019) Chung-Hang Leung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

(2019) Petri Pölönen et al.   ONCOGENE

Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer’s Disease Mice

(2019) Yang Yang et al.   Frontiers in Pharmacology

Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation

(2019) Yi Yang et al.   Autophagy

Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer

(2019) Cally J. Ho et al.   Cancers

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases

(2019) David Heras-Sandoval et al.   CELLULAR SIGNALLING

microRNA-592 blockade inhibits oxidative stress injury in Alzheimer's disease astrocytes via the KIAA0319-mediated Keap1/Nrf2/ARE signaling pathway

(2019) Guo-De Wu et al.   EXPERIMENTAL NEUROLOGY

Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models

(2019) Lingfeng Wang et al.   LIFE SCIENCES

FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

(2019) Ting Wan et al.   Oxidative Medicine and Cellular Longevity

The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction

(2019) Amin Karan et al.   PHARMACOLOGICAL RESEARCH

Autophagy and LRRK2 in the Aging Brain

(2019) Federica Albanese et al.   Frontiers in Neuroscience

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

(2018) Victor Tapias et al.   HUMAN MOLECULAR GENETICS

Autophagic Regulation of p62 is Critical for Cancer Therapy

(2018) Md. Islam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

(2018) Walter Gulisano et al.   JOURNAL OF ALZHEIMERS DISEASE

The redox-sensing geneNrf2affects intestinal homeostasis, insecticide resistance, and Zika virus susceptibility in the mosquitoAedes aegypti

(2018) Vanessa Bottino-Rojas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenium-enriched yeast inhibited β-amyloid production and modulated autophagy in a triple transgenic mouse model of Alzheimer’s Disease

(2018) Guoli Song et al.   Metallomics

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Andrographolide Protects PC12 Cells Against β-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway

(2018) Lili Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease

(2018) Yong-Xin Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line

(2018) Bei Cui et al.   BIOMEDICINE & PHARMACOTHERAPY

p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer

(2018) Pablo Sánchez‐Martín et al.   FEBS Journal

Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system

(2018) Kelsey Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1 – steering the cell through health and disease

(2018) Pablo Sánchez-Martín et al.   JOURNAL OF CELL SCIENCE

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments

(2018) Qing Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

(2018) Syed Zahid Ali Shah et al.   Frontiers in Molecular Neuroscience

Involvement of Nrf2 in myocardial ischemia and reperfusion injury

(2018) Yiming Shen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Autophagy and its role in gastric cancer

(2018) Yijing Cao et al.   CLINICA CHIMICA ACTA

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics

(2017) Anna Chiara Nascimbeni et al.   FEBS Journal

The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2

(2017) Yulong Li et al.   FEBS LETTERS

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)

(2017) Wang Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitive enhancing and antioxidant effects of tetrahydroxystilbene glucoside in A β 1 - 42 -induced neurodegeneration in mice

(2017) Miao Xie et al.   Journal of Integrative Neuroscience

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

(2017) Shasha Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases

(2017) Mazhar Pasha et al.   Oxidative Medicine and Cellular Longevity

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

(2017) Fiona Kerr et al.   PLoS Genetics

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

(2016) Thomas G. Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

(2016) Alice Goode et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

p62 improves AD-like pathology by increasing autophagy

(2016) A Caccamo et al.   MOLECULAR PSYCHIATRY

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models

(2016) Stuart A Lipton et al.   Cell Death & Disease

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells

(2015) Danfeng Xue et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

(2015) Sue Goo Rhee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

(2015) Mika Reinisalo et al.   Oxidative Medicine and Cellular Longevity

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD

(2014) Serena Lattante et al.   HUMAN MOLECULAR GENETICS

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Interaction Domains of p62: A Bridge Between p62 and Selective Autophagy

(2013) Xiaolong Lin et al.   DNA AND CELL BIOLOGY

Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms

(2013) Athanasios Valavanidis et al.   International Journal of Environmental Research and Public Health

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62

(2012) Henning Kleine et al.   Cell Communication and Signaling

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

An Exceptionally Potent Inducer of Cytoprotective Enzymes

(2010) Albena T. Dinkova-Kostova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY