Article
Cell Biology
Hong Zhu, An Bui, Arben Santo, Y. Robert Li
Summary: The present study demonstrated that D3T acted as a potent suppressor of LPS-induced proinflammatory responses in macrophages. Antioxidant induction, NF-kappa B suppression, and Nrf2 activation appeared to contribute to the anti-proinflammatory activity of D3T in macrophages.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meng-Chieh Shih, Chia-Ling Li, En-Chih Liao, Chung-Yang Yen, Ling-Jung Yen, Kai-Chun Wang, Ling-Ying Lu, Ting-Yu Chou, Ying-Chin Chen, Sheng-Jie Yu
Summary: This study aimed to investigate how 3H-1,2-dithiole-3-thione (D3T) reduces skin inflammation and modulates Th17 cell differentiation by inhibiting NLRP3 inflammasome activation. The results showed that D3T significantly reduced ear thickness, skin redness, and scaling in an imiquimod-induced psoriasis mouse model. It also inhibited the expression of NLRP3, caspase-1, and IL-1β in TNF-α stimulated HaCaT cells, indicating its potential as a promising treatment strategy for psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Oleg A. Rakitin
Summary: This review discusses recent developments in the synthesis of 3H-1,2-dithiole-3-thiones, including well-known procedures and important novel transformations for building the ring. It also explores diverse ring transformations of these compounds into various heterocyclic systems through 1,3-dipolar cycloaddition, replacement of sulfur atoms, and other unexpected reactions.
Article
Biochemistry & Molecular Biology
Josue Manriquez-Nunez, Ofelia Mora, Francesc Villarroya, Rosalia Reynoso-Camacho, Iza Fernanda Perez-Ramirez, Minerva Ramos-Gomez
Summary: Current research focuses on bioactive compounds that have the potential to promote macrophage polarization in order to reduce the development of inflammatory-related diseases. However, the effect of bioactive compounds under oxidative-stress-induced hyperglycemia on macrophage polarization has been insufficiently investigated. Our results indicate that hyperglycemia plays a fundamental role in modulating macrophage-induced inflammation in response to bioactive compounds.
Article
Biochemistry & Molecular Biology
Mingying Wang, Baojia Sun, Tao Ye, Yanbing Wang, Yonglian Hou, Siyuan Wang, Huaqi Pan, Huiming Hua, Dahong Li
Summary: 27 novel derivatives of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione of brefeldin A were designed and synthesized for improved cancer treatment. The antiproliferative activity of all the compounds was tested against human cancer cell lines and a normal cell line. Compound 10d showed the most potent cytotoxicity, with significant inhibition of metastasis and induction of apoptosis in breast cancer cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tsung-Tien Wu, Ying-Ying Chen, Chiu-Yi Ho, Tung-Chen Yeh, Gwo-Ching Sun, Ching-Jiunn Tseng, Pei-Wen Cheng
Summary: Studies have shown that RAGE induces EMT formation in LECs of diabetic cataracts, while D3T can reduce this effect. Experimental results demonstrate that D3T can reverse the fructose-induced effects, suggesting it may be a candidate for preventing cataracts in diabetic patients.
Article
Pharmacology & Pharmacy
Ivo S. F. Melo, Victor P. Ziviani, Barbara C. M. Barbosa, Felipe F. Rodrigues, Roger R. L. Silva, Leonardo da Silva Neto, Angelo de Fatima, Isabela C. Cesar, Renes R. Machado, Marcio M. Coelho
Summary: In this study, a novel H2S-releasing phthalimide hybrid was synthesized and demonstrated to have activity in models of inflammatory pain. The compound exerted its effects through the release of H2S and activation of ATP-sensitive potassium channels. This finding stimulates further research to evaluate H2S-releasing phthalimide hybrids as candidate analgesic drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, R. Sowmiya, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su
Summary: The authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppressing epithelial-mesenchymal transition and hyper-proliferation of retinal pigment epithelial cells. This offers a potential therapy for preventing vision loss after retinal detachment surgery.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Vladimir A. Ogurtsov, Oleg A. Rakitin
Summary: A new compound, 5,5'-thiobis(4-chloro-3H-1,2-dithiole-3-thione), has been synthesized via the reaction of 4,5-dichloro-3H-1,2-dithiole-3-thione with potassium isocyanate. The structure of the compound was characterized using various techniques.
Article
Cell Biology
Da-Rui Huang, Chang-Ming Dai, Shu-Yan Li, Xiao-Feng Li
Summary: Obacunone protects RPE cells from UVR-induced oxidative injury by activating the Nrf2 signaling cascade, showing potential therapeutic and protective effects.
Article
Multidisciplinary Sciences
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Summary: The research demonstrates the role of CIB2 in regulating the Rheb-mTORC1 signaling axis and autophagy in AMD. Molecular deficits and pathologies related to AMD were observed in Cib2 mutant mice and dry-AMD patient samples.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Chandresh Kumari, Avijit Goswami
Summary: A practical strategy for the synthesis of 3-acylimino-3H-1,2-dithiol derivatives via a metal-free annulation reaction of alkynylnitriles with thiocarboxylic acids mediated by ionic liquids [BMIM]Br has been reported. This simple protocol offers an easy and rapid access to a library of dithiol derivatives in moderate to good yields.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhimin Tang, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Dandan Zhang, Huiqin Gao, Hao Sun, Jing Zhang, Ping Gu
Summary: Research has identified that oxidative stress-induced RPE degeneration is mainly regulated by HO-1-mediated ferroptosis, controlled by the Nrf2-SLC7A11-HO-1 pathway. In mouse experiments, inhibiting HO-1 can block RPE ferroptosis, and using the HO-1 inhibitor ZnPP effectively rescues RPE degeneration with superior therapeutic effects. This highlights that targeting HO-1-mediated RPE ferroptosis could serve as an effective retinal-protective strategy for preventing retinal degenerative diseases, including AMD.
Article
Biochemistry & Molecular Biology
Seok Jae Lee, Soo-Jin Kim, Dong Hyun Jo, Kyu-Sang Park, Jeong Hun Kim
Summary: TGF-beta 1 induces EMT and oxidative stress in RPE cells, while inhibition of the mTORC1-NOX signaling pathway can prevent these processes and improve the regularity of RPE structure.