Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators

(2018) Alexander C Robeson et al.   EMBO JOURNAL

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

(2018) Ping Jun Zhu et al.   NATURE NEUROSCIENCE

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Control of spine maturation and pruning through proBDNF synthesized and released in dendrites

(2016) Lauren L. Orefice et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Caspase-3 Deficiency Results in Disrupted Synaptic Homeostasis and Impaired Attention Control

(2015) S.-C. Lo et al.   JOURNAL OF NEUROSCIENCE

Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb

(2014) Jaimie D. Adelson et al.   CEREBRAL CORTEX

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Cognitive flexibility and long-term depression (LTD) are impaired following  -catenin stabilization in vivo

(2014) F. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-2 as a tumour suppressor

(2013) J Puccini et al.   CELL DEATH AND DIFFERENTIATION

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Disruption of Glutamate Receptor-Interacting Protein in Nucleus Accumbens Enhances Vulnerability to Cocaine Relapse

(2013) Lisa A Briand et al.   NEUROPSYCHOPHARMACOLOGY

Long-term depression: a cell biological view

(2013) M. Sheng et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Regulation of AMPA receptor trafficking and synaptic plasticity

(2012) Victor Anggono et al.   CURRENT OPINION IN NEUROBIOLOGY

Dendritic BDNF Synthesis Is Required for Late-Phase Spine Maturation and Recovery of Cortical Responses Following Sensory Deprivation

(2012) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze

(2012) Zhifang Dong et al.   NEUROPHARMACOLOGY

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

(2011) Jeffrey B Carroll et al.   Molecular Neurodegeneration

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Ocular neuroprotection by siRNA targeting caspase-2

(2011) Z Ahmed et al.   Cell Death & Disease

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

A kinesin signaling complex mediates the ability of GSK-3  to affect mood-associated behaviors

(2010) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

(2009) Lisa Bouchier-Hayes et al.   MOLECULAR CELL

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

(2009) Wei Lu et al.   NEURON

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Pyramidal neurons: dendritic structure and synaptic integration

(2008) Nelson Spruston   NATURE REVIEWS NEUROSCIENCE

Transgenic Mice Lacking NMDAR-Dependent LTD Exhibit Deficits in Behavioral Flexibility

(2008) Russell E. Nicholls et al.   NEURON