Article
Medicine, Research & Experimental
Wylly Ramses Garcia-Nino, Cecilia Zazueta
Summary: Obesity is a significant public health issue linked to metabolic diseases, with KLFs playing a crucial role in regulating adipogenesis. Understanding adipocyte and adipose tissue development can offer insights for therapeutic strategies against obesity. The review focuses on the transcriptional role of KLF family members in adipocyte differentiation, highlighting interactions with various regulators and potential therapeutic targets.
Article
Cell Biology
Harun Ozturk, Harun Cingoz, Turan Tufan, Jiekun Yang, Sara J. Adair, Krishna Seshu Tummala, Cem Kuscu, Meric Kinali, Gamze Comertpay, Sarbajeet Nagdas, Bernadette J. Goudreau, Husnu Umit Luleyap, Yagmur Bingul, Timothy B. Ware, Wiliam L. Hwang, Ku-lung Hsu, David F. Kashatus, David T. Ting, Navdeep S. Chandel, Nabeel Bardeesy, Todd W. Bauer, Mazhar Adli
Summary: This study identifies ISL2 as a putative tumor suppressor in pancreatic ductal adenocarcinoma (PDA). ISL2 is epigenetically silenced and its reduced expression correlates with poor patient survival. ISL2 regulates the expression of metabolic genes and its depletion increases oxidative phosphorylation (OXPHOS). Spatial transcriptomic analysis shows heterogeneous intratumoral ISL2 expression, which correlates with the expression of critical metabolic genes.
DEVELOPMENTAL CELL
(2022)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Heba I. Ghamry
Summary: This study investigated the potential of Arthrospira platensis nanoparticles (NSP) in overcoming sorafenib resistance in diethyl nitrosamine-induced hepatocellular carcinoma (HCC) in rats. The study found that treatment with NSP, either alone or in combination with sorafenib, significantly reversed the harmful effects of diethyl nitrosamine, restored cancer biomarkers and antioxidant activities, and showed a major anticancer effect on HCC. These findings suggest that NSP could be a promising therapeutic option for suppressing tumors and overcoming sorafenib resistance in HCC.
Review
Medicine, Research & Experimental
Madhu Rani, Rashmi Kumari, Shashi Prakash Singh, Annu Devi, Preeti Bansal, Aisha Siddiqi, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani, M. Moshahid Alam Rizvi
Summary: MicroRNAs play a critical role in regulating genes, including FOXO transcription factors, which are important tumor suppressors. FOXO family members modulate various cellular processes and their abnormal expression due to microRNA down-regulation has been linked to tumor initiation, chemo-resistance, and progression. Chemo-resistance is a major challenge in cancer treatment, with a high percentage of cancer-related deaths associated with it. This article discusses the structure, functions, and posttranslational modifications of FOXO, as well as the role of microRNAs in carcinogenesis by regulating FOXOs at the post-transcriptional level. The miRNA-FOXO axis can be a potential target for novel cancer therapy to overcome chemo-resistance.
Article
Multidisciplinary Sciences
Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende, Namakkal S. Rajasekaran
Summary: This study identifies distinct miRNA signatures associated with Nrf2 overexpression in cardiac tissue, suggesting a potential role of these reductomiRs as mediators of Nrf2-dependent post-transcriptional regulation. The findings highlight the complex network of miRNAs and effector mRNAs encoding pathological hallmarks of cardiac stress-response, supporting Nrf2 as a putative regulator of cardiac miRNA expression and providing novel candidates for further mechanistic investigation into reductive stress and cardiac pathophysiology.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Abeer Salama, Rania Elgohary, Mohamed M. Amin, Sahar Abd Elwahab
Summary: This study aims to investigate the therapeutic impacts of Protocatechuic acid (PCA) against cyclophosphamide (CP)-induced pulmonary damage in rats. PCA exhibits antioxidant and anti-inflammatory properties and can protect cells by regulating the expression of various transcription factors and related signaling pathways. The results showed that PCA can decrease oxidative stress markers and upregulate the protein levels of cytoprotective defenses. In addition, PCA can alleviate the pathological changes induced by CP in the lungs. Therefore, PCA may be a promising adjuvant to prevent pulmonary damage in patients receiving CP treatment.
INFLAMMOPHARMACOLOGY
(2023)
Retraction
Biotechnology & Applied Microbiology
Babita Shashni, Karun Sharma, Rumani Singh, Kishore R. Sakharkar, Sarinder K. Dhillon, Yukio Nagasaki, Meena K. Sakharkar
Summary: This article has been retracted. Please refer to the Retraction Notice for more details.
Article
Medicine, Research & Experimental
Aya E. Mohamed, Ayman M. Mahmoud, Wafaa R. Mohamed, Tarek Mohamed
Summary: This study aimed to investigate the therapeutic potential and underlying mechanism of low-level laser therapy (LLLT) for liver fibrosis in rats. The results showed that LLLT attenuated CCl4-induced liver fibrosis by suppressing extracellular matrix (ECM) production and deposition, reducing oxidative injury and inflammation, and upregulating PPAR gamma and Nrf2/HO-1 signaling.
Article
Cell Biology
Yongqiang Ma, Zhi Tan, Qiang Li, Wenling Fan, Guangshun Chen, Yangyang Bin, Yi Zhou, Junfang Yi, Xiaohua Luo, Jieqiong Tan, Zhongzhou Si, Jiequn Li
Summary: By comparing liver gene expression between FXR knockout mice and MAFLD patients, this study identified new pathogenic pathways and target genes, shedding light on the pathogenesis of MAFLD. These findings may provide new insights into the pathophysiology of MAFLD and offer novel therapeutic targets for the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bayan Y. Ghanim, Nidal A. Qinna
Summary: This review highlights the important role of the Nrf2-ARE transcriptional pathway in regulating cellular defence systems and discusses different modes of hepatocyte cell death. Research suggests that Nrf2 plays a critical and complex regulatory role in cell death.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Fangfang Li, Jingfeng Peng, Hui Feng, Yiming Yang, Jianbo Gao, Chunrui Liu, Jie Xu, Yanru Zhao, Siyu Pan, Yixiao Wang, Luhong Xu, Wenhao Qian, Jing Zong
Summary: This study reveals that KLF9 exacerbates cardiac dysfunction, inflammatory response, and oxidative stress in diabetic cardiomyopathy. KLF9 may be a potential therapeutic target for diabetic cardiomyopathy.
Article
Cell Biology
Prathyusha Bagam, Gagandeep Kaur, Dhirendra Pratap Singh, Sanjay Batra
Summary: Cigarette smoking is the primary cause of chronic obstructive pulmonary disease. Oxidative stress induced by cigarette smoke leads to abnormal autophagy, resulting in acute lung injury. The study highlights the crucial role of FOXO1 and FOXO3a in regulating autophagy in response to cigarette smoke exposure.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Microbiology
Theodore J. Kottom, Kyle Schaefbauer, Eva M. Carmona, Andrew H. Limper
Summary: This study investigated the interaction between alveolar macrophages and Pneumocystis, revealing up- and downregulation of transcription factors. Validation of the results was done through qPCR experiments, highlighting important gene expression patterns in the mouse model of Pneumocystis pneumonia.
Article
Immunology
Jie-Qiong Ma, Yu-Jia Zhang, Zhi-Kai Tian, Chan-Min Liu
Summary: Bixin extracted from Bixa orellana seeds possesses anti-inflammatory, antioxidant, and anti-fibrosis properties by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways, improving renal damage induced by carbon tetrachloride in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Niklas Krafczyk, Lars-Oliver Klotz
Summary: FOXO family proteins are crucial transcriptional regulators that modulate cellular metabolism and antioxidant defense strategies. They regulate the expression of antioxidant genes to contribute to cellular response to oxidative stress.
Review
Food Science & Technology
Riccardo Secci, Alexander Hartmann, Michael Walter, Hans Joergen Grabe, Sandra van der Auwera-Palitschka, Axel Kowald, Daniel Palmer, Gerald Rimbach, Georg Fuellen, Israel Barrantes
Summary: This review focuses on the role of diet in protecting against aging, discussing biomarkers based on omics and clinical data, as well as the effects of berry-based interventions. It also emphasizes the importance of individuals' dietary history in geroprotection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, General & Internal
Svenja Fedde, Gerald Rimbach, Karin Schwarz, Anja Bosy-Westphal
Summary: Ultra-processed food constitutes a significant portion of daily energy intake in Germany and is associated with non-communicable diseases such as obesity, diabetes, cancer, cardiovascular disease, and depression. This association could be attributed to factors like high energy density, imbalanced nutritional composition, high glycemic index, and adverse additives found in ultra-processed food.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Nutrition & Dietetics
Daan Kremer, Adrian Post, Ulrike Seidel, Patricia Huebbe, Yvonne van der Veen, Dion Groothof, Antonio W. Gomes-Neto, Tim J. Knobbe, Kai Lueersen, Michele F. Eisenga, Gerjan J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: Through investigating the impact of boron intake on the long-term outcomes of kidney transplant recipients, the study found a strong association between high boron excretion and a lower risk of mortality, suggesting the potential for improving long-term survival through pathways other than previously suggested mechanisms.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Katharina S. Weber, Ilka Ratjen, Janna Enderle, Ulrike Seidel, Gerald Rimbach, Wolfgang Lieb
Summary: The study found that higher plasma boron concentrations were associated with a healthier diet, lower BMI, a more favorable cardio-metabolic risk profile, and seasonal variations.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Virginia Eickelberg, Kai Lueersen, Stefanie Staats, Gerald Rimbach
Summary: This article introduces the application of Drosophila melanogaster as a model organism in nutrition research, and provides a detailed description of the methods for phenotyping Drosophila. The practical application of fly phenotyping is demonstrated through a discussion of obese phenotypes in response to high-sugar diet and high-fat diet feeding. It is also found that the diets have impacts on the transcriptome and metabolome of Drosophila, which is important for understanding the underlying molecular mechanisms.
Article
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Weiye Gong, Karl Koehnlein, Verena Alexia Ohse, Frederike Iris Mueller, Josephine Priebs, Holger Steinbrenner, Lars-Oliver Klotz
Summary: A study identifies SEMO-1 as an enzyme in C. elegans that can degrade methanethiol and confer resistance to selenite. SEMO-1-deficient worms show increased resistance to oxidative stress and extended lifespan.
Article
Biochemistry & Molecular Biology
Anne Sophie Scheller, Thilo Magnus Philipp, Lars-Oliver Klotz, Holger Steinbrenner
Summary: SELENBP1 and CBS are reciprocally regulated during the spontaneous differentiation of human colorectal adenocarcinoma cells, paralleling their opposing regulation in colorectal cancer. Butyrate exposure imitates some aspects of spontaneous differentiation but does not elicit the same expression patterns of genes encoding H2S-modulating enzymes.
Article
Nutrition & Dietetics
Sebastian Schaffer, Gerald Rimbach, David Pieper, Niklas Hommen, Alexandra Fischer, Marc Birringer, Ulrike Seidel
Summary: This study investigated the contribution of minerals and trace elements in beverages to the daily intake of German consumers. The results showed that phosphorous, calcium, and magnesium were the main minerals found in beverages, while manganese was the most significant trace element. The study provides a foundation for the establishment of a mineral and trace element database for beverages in the future.
Article
Cell Biology
Virginia Eickelberg, Gerald Rimbach, Yvonne Seidler, Mario Hasler, Stefanie Staats, Kai Lueersen
Summary: This study found that both the quantity and quality of dietary fat can affect various traits in fruit flies, such as lifespan and fertility.
Article
Nutrition & Dietetics
Kai Lueersen, Alexandra Fischer, Ilka Bauer, Patricia Huebbe, Yukiko Uekaji, Keita Chikamoto, Daisuke Nakata, Naoto Hiramatsu, Keiji Terao, Gerald Rimbach
Summary: In the context of the growing prevalence of type 2 diabetes (T2DM), control of postprandial hyperglycemia is crucial for its prevention. Isoflavones in soy extract, enriched with hydroxylated metabolites through fermentation, exhibit anti-diabetic properties by inhibiting key enzymes, reducing glucose transport, and decreasing inflammatory markers. These properties are confirmed in an in vivo model using Drosophila melanogaster.
Article
Biochemistry & Molecular Biology
Manuela Yepes-Calderon, Daan Kremer, Adrian Post, Camilo G. G. Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J. J. Knobbe, Kai Lueersen, Michele F. F. Eisenga, Eva Corpeleijn, Martin H. H. De Borst, Gerjan J. J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: A study found that kidney transplant recipients have an increased risk of cardiovascular mortality. It also revealed an association between post-transplantation copper status and the risk of cardiovascular mortality, with a potential effect modification by sex. Among male recipients, higher plasma copper concentration was independently associated with a higher risk of cardiovascular mortality, while this association was absent among female recipients.
Article
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Leon Gernoth, Andreas Will, Maria Schwarz, Verena Alexia Ohse, Anna Patricia Kipp, Holger Steinbrenner, Lars-Oliver Klotz
Summary: Selenium-binding protein 1 (SELENBP1) acts as a methanethiol oxidase (MTO) in humans, converting methanethiol to hydrogen peroxide, hydrogen sulfide, and formaldehyde. Copper ions are essential for this MTO activity, as demonstrated by mutagenesis studies. Selenium binding, on the other hand, is not required for MTO activity. SELENBP1 ortholog SEMO-1 in the nematode C. elegans also requires copper ions for MTO activity. SELENBP1 degrades volatile sulfur compounds (VSCs), including methanethiol, suggesting its role in mitigating malodors.
Review
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Anne Sophie Scheller, Niklas Krafczyk, Lars-Oliver Klotz, Holger Steinbrenner
Summary: Tumor cells develop various metabolic adaptations to cope with increased demands and enhance stress resilience, including dysregulation of sulfur metabolism leading to elevated levels of volatile sulfur compounds (VSCs) in cancer patients. Methanethiol, the predominant cancer-associated VSC, has been proposed as a promising biomarker for non-invasive cancer diagnosis. Gut bacteria, such as Fusobacterium nucleatum, are the major source of methanethiol exposure, and proteins like SELENBP1 and METTL7B are involved in the production and degradation of methanethiol.
Correction
Biochemistry & Molecular Biology
S. Staats, A. E. Wagner, K. Luersen, A. Kunstner, T. Meyer, A. K. Kahns, S. Derer, S. Graspeuntner, J. Rupp, H. Busch, C. Sina, I. R. Ipharraguerre, G. Rimbach