Article
Cell Biology
Huanhuan Wang, Ge Yang, Yuan Tian, Jinjie Li, Lingbin Meng, Xin Jiang, Ying Xin
Summary: Sulforaphane (SFN) prevents angiotensin II-induced cardiomyocyte apoptosis by activating Nrf2 and inhibiting HDACs, leading to increased histone H3 acetylation levels.
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Huanhuan Wang, Yuan Tian, Qihe Zhang, Wenyun Liu, Lingbin Meng, Xin Jiang, Ying Xin
Summary: The study suggests that upregulating Nrf2 expression to activate antioxidant stress factors may play a crucial role in protecting against Ang II-induced aortic damage. Sulforaphane (SFN), an Nrf2 agonist, exerts a protective effect through the ERK/GSK-3β/Fyn pathway.
Article
Cell Biology
Xuling Su, Shudong Wang, Haiying Zhang, Ge Yang, Yang Bai, Pinyi Liu, Lingbin Meng, Xin Jiang, Ying Xin
Summary: This study demonstrated that Sulforaphane (SFN) exerts its cardioprotective effect through epigenetic modification of Nrf2, which improves chronic Ang II-induced cardiac damage. SFN reduces CpG hypermethylation, promotes Ac-H3 accumulation in the Nrf2 promoter region, inhibits global DNMT and HDAC activity, and decreases the protein expression of key DNMT and HDAC enzymes, contributing to long-term activation of cardiac Nrf2.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Pinyi Liu, Xiaoming Dong, Chao Dong, Guowen Hou, Wenyun Liu, Xin Jiang, Ying Xin
Summary: MHRT exerts a protective effect against Ang II-induced myocardial injury by reducing oxidative stress and NLRP3 inflammasome activation via Nrf2 activation.
Article
Biochemistry & Molecular Biology
Xiaoqian Wu, Jianrong Huang, Junyuan Tang, Yuling Sun, Guojun Zhao, Cuishi Yan, Zhenghong Liu, Wei Yi, Suowen Xu, Xiyong Yu
Summary: In this study, isoginkgetin (IGK) was found to protect against obesity-induced metabolic cardiomyopathy by activating the Nrf2 signaling pathway. IGK stabilized Nrf2 protein to protect against oxidative stress and mitochondrial damage induced by obesity. These findings highlight the potential therapeutic use of IGK in treating obesity-induced cardiomyopathy.
Article
Cell Biology
Yuanxiu Song, Hongxia Li, Shuhong Ma, Min Zhu, Wen-Jing Lu, Feng Lan, Ming Cui
Summary: Alcoholic cardiomyopathy (ACM) is a myocardial injury caused by long-term heavy drinking. This study used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to establish an in vitro model of ACM and found that AngII and AT1R play a role in alcohol-induced myocardial damage through oxidative stress. The mechanism may involve the regulation of NOX.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. Mckee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G. N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Summary: The study found that p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to other cellular functions. It negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction. The study also identified p97 as an NRF2-target gene that maintains redox homeostasis through a negative feedback loop, and found a positive correlation between NRF2 activation and p97 expression in human cancer patients. Inhibition of both NRF2 and p97 could be a promising treatment strategy for cancer patients.
Article
Medicine, Research & Experimental
Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu, Yan-Fen Chai
Summary: There is an abnormal activation of the renin angiotensin aldosterone system (RAAS) in patients with Sepsis-Induced Cardiomyopathy (SIC). This study measured the protein concentrations of angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) in peripheral plasma collected from SIC patients and healthy controls, and explored the relationship between SIC, Ang II, and Ang-(1-7) levels. It was found that SIC patients had elevated Ang II and Ang II/Ang-(1-7) levels, while the healthy controls had higher Ang-(1-7) levels. Additionally, exogenous Ang-(1-7) showed protective effects against SIC by inhibiting inflammatory and oxidative stress pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Junsei Taira, Ryuji Tsuda, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takayuki Ogi
Summary: The low-level antioxidant activity of pancreatic islets causes type 1 diabetes and failure in islet isolation and cell transplantation. Pteryxin, a natural product, was found to activate antioxidant enzymes even under oxidative stress. Pteryxin treatment enhanced antioxidant gene expressions in MIN6 cells and increased glutathione levels, suggesting its potential as a preservative agent during islet transplantation.
Article
Cell Biology
Fangfang Li, Jingfeng Peng, Hui Feng, Yiming Yang, Jianbo Gao, Chunrui Liu, Jie Xu, Yanru Zhao, Siyu Pan, Yixiao Wang, Luhong Xu, Wenhao Qian, Jing Zong
Summary: This study reveals that KLF9 exacerbates cardiac dysfunction, inflammatory response, and oxidative stress in diabetic cardiomyopathy. KLF9 may be a potential therapeutic target for diabetic cardiomyopathy.
Review
Biology
Joao Pedro Thimotheo Batista, Andre Oliveira Vilela de Faria, Thomas Felipe Silva Ribeiro, Ana Cristina Simoes e Silva
Summary: Diabetic cardiomyopathy is characterized by myocardial dysfunction in type 2 diabetes patients without traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease. The activation of the renin-angiotensin system (RAS), oxidative stress, lipotoxicity, maladaptive immune responses, imbalanced mitochondrial dynamics, impaired myocyte autophagy, increased myocyte apoptosis, and fibrosis all contribute to the development of diabetic cardiomyopathy. Research has shown that the RAS plays a crucial role in this condition, with over-activation of the classical RAS axis leading to increased oxidative stress, fibrosis, and cardiac remodeling, while angiotensin-(1-7) has a protective effect. ACE inhibitors and angiotensin receptor blockers have been shown to improve heart functioning and reduce the occurrence of diabetic cardiomyopathy.
Article
Medicine, Research & Experimental
Samar A. Antar, Walied Abdo, Reda S. Taha, Amira E. Farage, Laila E. El-Moselhy, Mohamed E. Amer, Ahmed S. Abdel Monsef, Amer M. Abdel Hamid, Emadeldin M. Kamel, Ahmad F. Ahmeda, Ayman M. Mahmoud
Summary: This study found that telmisartan has a protective effect on renal damage in diabetic rats, reducing hyperglycemia, oxidative stress, inflammation, apoptosis, and angiogenesis. It achieves this protective effect by upregulating the Nrf2/HO-1 signaling pathway.
Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ling Wang, Yue-Qin Zeng, Juan-Hua Gu, Rui Song, Peng-Hui Cang, Yong-Xuan Xu, Xiao-xia Shao, Li-Jin Pu, Hai-Yun Luo, Xin-Fu Zhou
Summary: Oxidative stress plays a crucial role in diabetic cardiomyopathy, and the novel oral edaravone (OED) has shown potential in alleviating oxidative stress and improving diastolic dysfunction. OED reduced oxidative stress and improved cardiac parameters in type 2 diabetic rats, as well as reduced reactive oxygen species and cell damage in H9c2 cells. These effects were mediated by the activation of the Nrf2 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Oncology
Bin Wang, Qin Zhao, Yuyu Zhang, Zijing Liu, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Hypoxic tumor microenvironment (TME) may be a major barrier limiting the efficacy of immunotherapy, through inducing immune suppression and resistance. Targeting hypoxia could enhance the efficacy of immunotherapy and provide a promising combinational therapeutic strategy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Jinlong Wei, Qin Zhao, Min Yao, Lingbin Meng, Ying Xin, Xin Jiang
Summary: A 29-year-old male patient with GPA exclusively in the eyelid area underwent successful radiotherapy, leading to a significant reduction of the lesion and obvious symptom relief. This case highlights the importance of considering novel treatments such as radiotherapy for GPA patients when the standard treatment model fails to deliver positive results.
Review
Medicine, Research & Experimental
Shiyu Liu, Weiyan Shi, Qin Zhao, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: TTFields is a treatment technology that induces apoptosis of cancer cells by generating an electric field, and is promising for the treatment of glioblastoma with few side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhuangzhuang Zheng, Bin Wang, Qin Zhao, Yuyu Zhang, Jinlong Wei, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Radiotherapy is effective in the treatment of head and neck cancer, but can lead to serious complications such as radiation-induced temporal lobe injury (TLI). Various imaging techniques such as CT and MRI can be used to observe structural changes and dose-dependent alterations in gray and white matter volume. Further advanced imaging modalities like DTI, DKI, SWI, rs-fMRI, MRS, and PET can help in early diagnosis and prognosis evaluation of TLI based on functional, molecular, and cellular processes.
EUROPEAN RADIOLOGY
(2022)
Review
Immunology
Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Head and neck cancer, primarily head and neck squamous cell carcinoma, is commonly treated with surgery, radiotherapy, chemotherapy, and immunotherapy. Immunotherapy, particularly for HPV-positive patients, has shown promising results possibly due to higher immune cell infiltration and differential expression of immune checkpoints in tumors. Personalized immunotherapy trials are also being conducted in HPV-positive patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Huanhuan Wang, Qin Zhao, Yangyu Zhang, Jinlong Wei, Bin Wang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: The study found that for recurrent/metastatic head and neck squamous cell carcinoma, chemotherapy regimens such as cetuximab/platinum/5-FU, pembrolizumab/platinum/5-FU or pembrolizumab alone, and nivolumab showed better efficacy with lower rates of adverse events. Immunotherapy has achieved better efficacy in treating the condition.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kunzhi Chen, Zhuangzhuang Zheng, Lijuan Ding, Na Tao, Libo Wang, Wenming Xia, Huidong Wang, Xin Jiang
Summary: A systematic quantitative evaluation of IMRT quality change in modified radical mastectomy using Plan-IQ feasibility tool was conducted. Results showed that the RP group had significantly better OAR dose limits compared to the NP group, with a decrease in total scores. PTV scores decreased in the RP group, while OAR scores improved.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Wenxia Shi, Xue Hou, Xueying Bao, Wei Hou, Xuehua Jiang, Lixin Ma, Xin Jiang, Lihua Dong
Summary: RISNHL is a common adverse effect in patients with head and neck cancer, associated with damage caused directly by ionizing radiation and the radiation-induced bystander effect. Studies have shown that RISNHL mainly involves post-RT inflammatory response and cell death. Lowering the incidence of RISNHL can be achieved through advanced treatment techniques and preventive measures.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Jing Su, Qin Zhao, Zhuangzhuang Zheng, Huanhuan Wang, Chenbin Bian, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Radiation therapy plays a crucial role in cancer treatment, but the hypoxic microenvironment in solid tumors can affect its effectiveness. Ferroptosis, a newly discovered cell death mechanism, can enhance the radiosensitivity of hypoxic tumor cells by amplifying oxidative stress or inhibiting antioxidant regulation.
Review
Biochemistry & Molecular Biology
Yuan Tian, Ziting Gao, Wenyun Liu, Jinjie Li, Xin Jiang, Ying Xin
Summary: Diabetic cardiomyopathy is a major cause of mortality and morbidity in diabetes patients. Its pathogenesis involves multiple factors, and recent studies have found that long non-coding RNAs play a critical role in this process, providing insights for the development of diagnostic and therapeutic strategies.
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Biochemistry & Molecular Biology
Pinyi Liu, Xiaoming Dong, Chao Dong, Guowen Hou, Wenyun Liu, Xin Jiang, Ying Xin
Summary: MHRT exerts a protective effect against Ang II-induced myocardial injury by reducing oxidative stress and NLRP3 inflammasome activation via Nrf2 activation.
Review
Pharmacology & Pharmacy
Wei Liu, Zining Tan, Mengrou Geng, Xin Jiang, Ying Xin
Summary: This article discusses the relationship between the renin-angiotensin system (RAS) and the gut microbiota, noting that Angiotensin II (Ang II) can lead to an imbalance in the gut microbiota, thereby exacerbating disease progression. In addition, angiotensin converting enzyme 2 can alleviate the deleterious effects of Ang II and regulate gut microbial dysbiosis and immune responses associated with coronavirus disease 19. Deciphering these mechanisms will provide a theoretical basis for novel therapeutic strategies for disease prevention and treatment. Finally, therapies targeting the gut microbiota to treat Ang II-related disorders are discussed.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bin Wang, Yin Han, Yuyu Zhang, Qin Zhao, Huanhuan Wang, Jinlong Wei, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 have shown promise in treating various types of malignancies by boosting tumor-specific T cell immunity. However, acquired resistance to ICI therapy remains a major obstacle. In this review, we discuss the mechanisms of acquired resistance to ICIs, including lack of neoantigens, mutations in IFN-γ/JAK signaling, activation of alternate inhibitory immune checkpoints, immunosuppressive tumor microenvironment, epigenetic modification, and dysbiosis of the gut microbiome. Potential therapeutic strategies to reverse ICI resistance are also briefly explored.
CELL AND BIOSCIENCE
(2023)
Review
Oncology
Shiyu Liu, Qin Zhao, Weiyan Shi, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: High-grade gliomas (HGGs) are the most common primary malignant brain tumors, and treatment plans are personalized based on patient characteristics. The basic treatment plan involves surgery, radiotherapy, and chemotherapy, while comprehensive treatment schemes combine various modalities such as radiotherapy, chemotherapy, molecular targeted therapy, and immunotherapy.