Small-Molecule Inhibitors of Reactive Oxygen Species Production

Neuroprotective effects of novel nitrones: In vitro and in silico studies

(2020) Saira Cancela et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Developing Inhibitors of the p47phox–p22phox Protein–Protein Interaction by Fragment-Based Drug Discovery

(2020) Sara Marie Øie Solbak et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury

(2020) Mengwei Wang et al.   NEUROCHEMICAL RESEARCH

Selenium and selenoproteins: it’s role in regulation of inflammation

(2020) Sneha Hariharan et al.   INFLAMMOPHARMACOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

(2020) Joana Reis et al.   Redox Biology

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances on Nitrones Design for Stroke Treatment

(2020) José Marco-Contelles   JOURNAL OF MEDICINAL CHEMISTRY

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

(2019) Young J. Yauger et al.   Journal of Neuroinflammation

New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective (Z)-N-tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment

(2019) Mourad Chioua et al.   JOURNAL OF MEDICINAL CHEMISTRY

Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I

(2019) Atsushi Banba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual inhibition of NADPH oxidases and xanthine oxidase potently prevents salt-induced stroke in stroke-prone spontaneously hypertensive rats

(2019) Davis Ngarashi et al.   HYPERTENSION RESEARCH

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow

(2019) Y. Li et al.   Redox Biology

A novel NADPH oxidase inhibitor targeting Nox4 in TGFβ-induced lens epithelial to mesenchymal transition

(2019) Shannon Das et al.   EXPERIMENTAL EYE RESEARCH

Inducible nitric oxide synthase inhibitors: A comprehensive update

(2019) Richa Minhas et al.   MEDICINAL RESEARCH REVIEWS

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

(2019) Fiona Augsburger et al.   Redox Biology

Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative

(2019) Seul Gee Lee et al.   Pharmaceutics

S1QELs suppress mitochondrial superoxide/hydrogen peroxide production from site IQ without inhibiting reverse electron flow through Complex I

(2019) Hoi-Shan Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selegiline: a molecule with innovative potential

(2019) Tamás Tábi et al.   JOURNAL OF NEURAL TRANSMISSION

Ischemic stroke in neonatal and adult astrocytes

(2019) Miren Revuelta et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

(2019) Alexia Belavgeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ischemic stroke and mitochondria: mechanisms and targets

(2019) Syed Suhail Andrabi et al.   PROTOPLASMA

The NADPH Oxidase Family and Its Inhibitors

(2019) Mathieu Chocry et al.   ANTIOXIDANTS & REDOX SIGNALING

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

(2019) Vu Thao-Vi Dao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hormones and oxidative stress: an overview

(2019) Gagan B. N. Chainy et al.   FREE RADICAL RESEARCH

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells

(2018) Tsuyoshi Yamamoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

(2018) Markus Bredemeier et al.   BMC Cardiovascular Disorders

A multiple treatment comparison meta-analysis of monoamine oxidase type B inhibitors for Parkinson's disease

(2018) C. D. Binde et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease

(2018) Yi-xiang Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke

(2018) Kevin M. Nash et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis

(2018) Joana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

(2018) Jakob S. Pallesen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Non-Central Nervous System (CNS) Diseases

(2018) Ronan GEALAGEAS et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

(2018) Óscar M. Bautista-Aguilera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

(2018) Grazia Tamma et al.   Oxidative Medicine and Cellular Longevity

Vitamin B2 blocks development of Alzheimer’s disease in APP/PS1 transgenic mice via anti-oxidative mechanism

(2018) Rong Zhao et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

(2018) Edgar Djaha Yoboue et al.   Cell Death & Disease

A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats

(2018) Debra Dorotea et al.   PHARMACOLOGY

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

(2018) Xuan Wang et al.   PLoS One

Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction

(2018) Si-yu Zeng et al.   BIOMEDICINE & PHARMACOTHERAPY

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases

(2018) Moussa B. H. Youdim   JOURNAL OF NEURAL TRANSMISSION

L‑Deprenyl exerts cytotoxicity towards acute myeloid leukemia through inhibition of mitochondrial respiration

(2018) Ilhwan Ryu et al.   ONCOLOGY REPORTS

The Dual Role of Inducible Nitric Oxide Synthase in Myocardial Ischemia/Reperfusion Injury: Friend or Foe?

(2018) Xin Yu et al.   Oxidative Medicine and Cellular Longevity

Targeting reactive oxygen species for respiratory infection: Fact or fancy?

(2018) Stavros Selemidis   RESPIROLOGY

Ischemic brain injury: New insights on the protective role of melatonin

(2017) Eva Ramos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

(2017) Israel Pérez-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II

(2017) Paavo Korge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reaction and Scavenging Mechanism of β-Carotene and Zeaxanthin with Reactive Oxygen Species

(2017) Azusa Nishino et al.   Journal of Oleo Science

APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury

(2017) Jin Joo Cha et al.   LABORATORY INVESTIGATION

Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function

(2017) Neil R. Sims et al.   NEUROCHEMISTRY INTERNATIONAL

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

(2017) Merry W. Ma et al.   Oxidative Medicine and Cellular Longevity

Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing

(2017) Damien Maggiorani et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

ROS Are Good

(2017) Ron Mittler   TRENDS IN PLANT SCIENCE

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Longer Duration of MAO-B Inhibitor Exposure is Associated with Less Clinical Decline in Parkinson’s Disease: An Analysis of NET-PD LS1

(2017) Robert A. Hauser et al.   Journal of Parkinsons Disease

Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

(2017) Selim Fakhruddin et al.   Journal of Diabetes Research

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease

(2016) Rodica Lighezan et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study

(2016) Tatsuo Hosoya et al.   CLINICAL RHEUMATOLOGY

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors

(2016) Joana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion

(2016) Zhong Liu et al.   Journal of NeuroInterventional Surgery

Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects

(2016) Maria Giulia Battelli et al.   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

(2016) Danina M. Muntean et al.   Oxidative Medicine and Cellular Longevity

Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium

(2016) John T. Szilagyi et al.   TOXICOLOGICAL SCIENCES

Diabetes mellitus and oxidative stress—A concise review

(2016) Ullah Asmat et al.   SAUDI PHARMACEUTICAL JOURNAL

A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase

(2016) Jung Hee Joo et al.   Scientific Reports

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

(2015) E. Anvari et al.   FREE RADICAL RESEARCH

NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells

(2015) Joanna Stanicka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Dose Nicotinamide Suppresses ROS Generation and Augments Population Expansion during CD8+ T Cell Activation

(2015)   MOLECULES AND CELLS

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility

(2015) François Chauvigné et al.   Scientific Reports

Inhibition of monoamine oxidase A increases recovery after experimental cardiac arrest

(2015) Vilma Vuohelainen et al.   Interactive Cardiovascular and Thoracic Surgery

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

(2014) Paramita Mukherjee et al.   CHEMICAL SOCIETY REVIEWS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

(2014) Paramita Mukherjee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indazole- and Indole-5-carboxamides: Selective and Reversible Monoamine Oxidase B Inhibitors with Subnanomolar Potency

(2014) Nikolay T. Tzvetkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Glutathione revisited: a better scavenger than previously thought

(2014) Guido R. M. M. Haenen et al.   Frontiers in Pharmacology

Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts

(2013) Nina Kaludercic et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

(2013) S. Schildknecht et al.   CURRENT MEDICINAL CHEMISTRY

Riboflavin (vitamin B2) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense againstListeria monocytogenes

(2013) Michael Schramm et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species in the Immune System

(2013) Yuhui Yang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Reactive Oxygen Species in Vascular Formation and Development

(2013) Yijiang Zhou et al.   Oxidative Medicine and Cellular Longevity

Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors

(2013) Eugenia Cifuentes-Pagano et al.   MedChemComm

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics

(2012) Frederick A Villamena et al.   Future Medicinal Chemistry

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats

(2012) Keisuke Morimoto et al.   JOURNAL OF VASCULAR SURGERY

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity

(2012) Shaojun Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

(2012) Maria Julia Marchissio et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

(2012) Ruben Quintana-Cabrera et al.   Nature Communications

Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis

(2011) Stéphane Quideau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells

(2011) Patricia Sancho et al.   BIOCHEMICAL PHARMACOLOGY

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

(2011) Gregory J. Gatto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease

(2010) Lauren Broom et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

(2010) Haitao Ji et al.   JOURNAL OF MEDICINAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

(2010) K. Matsumoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Cytoprotective Effect of N-acetyl-L-cysteine against ROS-Induced Cytotoxicity Is Independent of Its Ability to Enhance Glutathione Synthesis

(2010) Fengjiao Zhang et al.   TOXICOLOGICAL SCIENCES

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Selenoproteins and Protection against Oxidative Stress: Selenoprotein N as a Novel Player at the Crossroads of Redox Signaling and Calcium Homeostasis

(2009) Sandrine Arbogast et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

(2009) Takahiro Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Nitrone Free Radical Scavenger NXY-059 Is Neuroprotective when Administered after Traumatic Brain Injury in the Rat

(2009) Fredrik Clausen et al.   JOURNAL OF NEUROTRAUMA

Edaravone, a Free Radical Scavenger, Protects against Retinal Damage in Vitro and in Vivo

(2009) Y. Inokuchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

The Novel Antioxidant Edaravone: From Bench to Bedside

(2008) Toshiaki Watanabe et al.   Cardiovascular Therapeutics

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

(2008) Elsa D Garcin et al.   Nature Chemical Biology

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION

Radical scavenging properties of nicotinamide and its metabolites

(2007) Adam Sikora et al.   RADIATION PHYSICS AND CHEMISTRY