Article
Chemistry, Applied
Asako Narai-Kanayama, Kazuhiro Chiku, Hiroshi Ono, Takamitsu Momoi, Miho Hiwatashi-Kanno, Akiko Kobayashi, Hiroko Matsuda, Mitsuru Yoshida, Tsutomu Nakayama
Summary: Theaflavin, the polyphenol responsible for the orange color and bioactivities of black tea, can undergo autoxidation to change its color to brown under neutral and mild alkaline conditions. The presence of thiol compounds such as cysteine, glutathione, or N-acetyl cysteine can inhibit the browning of theaflavin solution and lead to a decrease in the concentrations of both theaflavin and thiol group over time. LC-MS analysis revealed the formation of novel adducts of thiol compounds. The chemical structures of theaflavin-cysteine and theaflavin-glutathione adducts were determined using NMR, showing the addition of a new cyclic structure to the theaflavin-cysteine adduct.
Article
Toxicology
Tomas Rousar, Jiri Handl, Jan Capek, Pavlina Nyvltova, Erika Rousarova, Miroslav Kubat, Lenka Smid, Jana Vanova, David Malinak, Kamil Musilek, Petr Cesla
Summary: Cysteine conjugates of acetaminophen and p-aminophenol induce harmful cellular damage in human kidney cells, including a decrease in glutathione levels and disappearance of mitochondrial membrane potential.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniela Giustarini, Aldo Milzani, Isabella Dalle-Donne, Ranieri Rossi
Summary: Glutathione (GSH) has special antioxidant properties due to its high concentration, ubiquity, and reactivity. In diseases where oxidative stress plays a role, GSH concentration is reduced, making cells more prone to damage. This review discusses strategies for increasing cellular GSH, including GSH itself, derivatives, activators, prodrugs, foods, and diets, as well as their mechanisms and advantages/disadvantages.
Review
Biochemistry & Molecular Biology
Marcos A. Martinez-Banaclocha
Summary: Encouraging recent data have identified gene variants and expansions associated with aging pathways, including DNA replication and repair, telomere and stem cell maintenance, regulation of the redox microenvironment, and intercellular communication. The optimization of transcriptional regulation and protein crosstalk is essential for cellular rejuvenation in addition to variations in gene sequences. The redox-active cysteinome and antioxidant systems play crucial roles in cellular regulation and aging, and targeting them with GSH precursors could be a beneficial therapeutic approach for Parkinson's disease.
Article
Agriculture, Dairy & Animal Science
Laryssa G. Barrozo, Lais R. F. M. Paulino, Bianca R. Silva, Efigenia C. Barbalho, Danisvania R. Nascimento, Miguel F. Lima Neto, Jose R. Silva
Summary: NAC, as an antioxidant, plays a crucial role in promoting GSH biosynthesis and regulating cell proliferation. Studies on in vitro culture, oocyte maturation, embryonic development, and cryopreservation show beneficial effects of NAC in protecting cells from oxidative stress damage.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shubha Shakya, Reagan M. McGuffee, David A. Ford
Summary: Hypochlorous acid is formed when leukocyte myeloperoxidase attacks the phospholipid plasmalogen molecular subclass, leading to the formation of 2-chlorofatty aldehydes (2-ClFALDs). The biological role of 2-ClFALD is not well understood. In this study, the effects of 2-ClHDA, an analog of 2-ClFALD, on the metabolic activity of RAW 264.7 cells were investigated. It was found that 2-ClHDA reduced the metabolic activity of the cells in a dose-dependent manner. Furthermore, N-acetyl cysteine (NAC) was shown to reduce the toxic effects of 2-ClFALD by reducing protein modification.
Article
Pharmacology & Pharmacy
Shoto Sasaki, Takayuki Negishi, Takamasa Tsuzuki, Kazunori Yukawa
Summary: This study reveals the toxicity mechanisms of methylmercury on rat cerebellar astrocytes, and identifies the involvement of reactive oxygen species (ROS) in the toxicity. Antioxidants have been tested to suppress the toxicity of methylmercury.
Review
Biochemistry & Molecular Biology
Daniel Adon Mapamba, Elingarami Sauli, Lucy Mrema, Julieth Lalashowi, David Magombola, Joram Buza, Willyhelmina Olomi, Robert S. Wallis, Nyanda Elias Ntinginya
Summary: NAC may have a positive impact on the treatment of TB, but current research lacks sufficient evidence to support its overall effects, requiring more clinical trials for validation.
Article
Chemistry, Physical
Bozena Bukowska
Summary: The study found that TCEP and TCPP only disrupted redox balance in very high concentrations, increasing ROS and methemoglobin levels and inducing morphological changes, hemolysis, and eryptosis in the studied cells. TCPP exhibited a stronger oxidative, eryptotic, and hemolytic potential than TCEP in human red blood cells. Comparing these findings with published data, it confirms a much lower toxicity of OPFRs compared to brominated flame retardants.
Article
Agriculture, Multidisciplinary
Linhui Feng, Heping Cui, Pusen Chen, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho
Summary: An Amadori rearrangement product derived from ribose and glutathione was studied, and it was found that higher temperatures accelerate its degradation and favor the formation of certain compounds. Additionally, extra-added glutathione or its constituent amino acids promote the generation of volatile compounds, with cysteine being the most effective in producing sulfur-containing volatiles.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Kenari, Szilard Molnar, Igor D. Borges, Hamilton B. Napolitano, Pal Perjesi
Summary: Non-enzymatic thiol addition has various biological effects, and can form small-molecule thiol or protein thiol adducts in vivo. The reactions between synthetic cyclic chalcone analogs and reduced glutathione and N-acetylcysteine were studied using HPLC-UV method. The rates and compositions of the reactions depended on the substitution and pH conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
I. N. Bardasov, S. S. Chunikhin, A. U. Alekseeva
Summary: An approach using a silver salt with an organic anion based on nicotinonitrile was proposed for the quantitative fluorimetric determination of various anions and thiols, including glutathione and cysteine.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2023)
Article
Cell Biology
Xia Pan, Daniela Giustarini, Florian Lang, Ranieri Rossi, Thomas Wieder, Martin Koeberle, Mehrdad Ghashghaeinia
Summary: In this study, we found that desipramine, a representative of tricyclic antidepressants, promotes recovery of depressed patients by inhibiting the reuptake of serotonin and norepinephrine. Additionally, desipramine enhances programmed erythrocyte death through calcium ion regulation.
Article
Neurosciences
Maya Junghans, Felix John, Hilal Cihankaya, Daniel Schliebs, Konstanze F. Winklhofer, Verian Bader, Johann Matschke, Carsten Theiss, Veronika Matschke
Summary: This study found that the levels of reactive oxygen species (ROS) were elevated in motor neurons of an ALS model, leading to an increased number of DNA damage response proteins. The study also identified a deficit in ROS detoxification mechanisms in the ALS model. The results suggest that maintaining redox homeostasis may play a key role in ALS therapy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Marjan Sebghati, Atekeh Tarahhomi, Marjan Sadat Bozorgvar, Dan G. Dumitrescu, Arie van der Lee
Summary: The study investigated the crystalline forms of tris(pyridin-2-yl)phosphoric triamide both as a metal complex and purely organic pseudopolymorphs. Compound 1 represents a unique example of a chelate phosphoric triamide complex.
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Analytical
Akang Dan, Shasha Zhang, Zhongliang Chen, Jinghan Dong, Wenjun Zheng, Yuxin Tu, Zian Lin, Zongwei Cai
Summary: A simple and highly selective analytical method for phthalate monoesters (mPAEs) was developed using Cu2+-immobilized magnetic covalent organic frameworks. The method showed wide linear ranges, low limits of detection, and good correlation coefficients for the detection of mPAEs. The method was successfully applied to the sensitive detection of mPAEs in mouse plasma samples.
Article
Meteorology & Atmospheric Sciences
Jianguo Wu
Summary: This study used fuzzy set-based classification, Monte Carlo scheme, and climate shift data to determine the risk of reduction in distributional ranges of alpine graminoid species. The results showed that the main factor leading to range shifts was changes in the temperature index. Adaptation measures are needed to cope with future climatic conditions.
THEORETICAL AND APPLIED CLIMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yue Shen, Sheng-Di Wu, Yao Chen, Xin-Yue Li, Qin Zhu, Kiyoko Nakayama, Wan-Qin Zhang, Cheng-Zhao Weng, Jun Zhang, Hai-Kun Wang, Jian Wu, Wei Jiang
Summary: This study aimed to characterize the gut microbiota in patients with chronic hepatitis B virus infection-associated liver diseases (HBV-CLD) and evaluate their effects on peripheral immunity. The results revealed that disease progression and antiviral treatment were the two main factors contributing to the shift in microbiome and metabolome composition in HBV-CLD patients.
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Yinchun Fang, Jianguo Wu, Guojie Ma, Qufu Wei
Summary: Polylactic acid (PLA) fibre is a renewable and biodegradable synthetic polymer that has gained attention in textiles. However, its dyeing process faces challenges, and a waterless dyeing method using disperse dyes is being explored as an alternative. This study investigated the waterless dyeing of PLA fibre using different disperse dyes and decamethylcyclopentasiloxane (D5) as the medium. Optimal dyeing process conditions were determined, and it was found that disperse dyes with a monoazo structure were most suitable for PLA waterless dyeing. The research provides a basis for developing suitable dyes for waterless dyeing of PLA using D5.
COLORATION TECHNOLOGY
(2023)
Article
Environmental Sciences
Yan Ding, Dongqi Wang, Guanghui Zhao, Shu Chen, Taihu Sun, Hechen Sun, Chenyang Wu, Yizhe Li, Zhongjie Yu, Yu Li, Zhenlou Chen
Summary: Plant litter input is a crucial factor in the turnover of soil/sediment organic carbon (SOC). This study investigated the effects of leaf litter and stem litter input on SOC dynamics using the 13C isotope technique. It was found that both leaf and stem litter input facilitated SOC accumulation, with leaf litter having a higher contribution. However, leaf litter input also promoted SOC mineralization more than stem litter input. Overall, litter input led to a net increase in SOC accumulation but accelerated the loss of native SOC.
ENVIRONMENTAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yu Song, Jiayi Wei, Rong Li, Ruifeng Fu, Pei Han, Heming Wang, Guangcong Zhang, Shuyu Li, Sinuo Chen, Zhiyong Liu, Yicheng Zhao, Changfeng Zhu, Jimin Zhu, Shuncai Zhang, Hao Pei, Jiefei Cheng, Jian Wu, Ling Dong, Guangqi Song, Xizhong Shen, Qunyan Yao
Summary: TrkB is decreased in liver fibrosis and its overexpression can inhibit the activation of TGF-beta/SMAD signaling and alleviate hepatic fibrosis, making it a potential therapeutic target.
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Industrial
Ruiyu Xu, Song Huang, Zheren Song, Yuanyuan Gao, Jianguo Wu
Summary: This article proposes a deep mixed-effects modeling approach for anomaly detection in additive manufacturing. It captures the relationship between the melt pool temperature and other sensing data using a deep neural network, and incorporates random-effect and residual terms to account for variations and autocorrelations. Control charts based on T2 and generalized likelihood ratio statistics are developed for online monitoring.
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Geochemistry & Geophysics
Imali Kaushalya Herath, Guitao Shi, Qian Zhao, Yilan Li, Danhe Wang, Su Jiang, Yangjie Li, Zhenlou Chen, Roberto Bargagli
Summary: This study analyzed the sources and cycling of nitrate (NO3-) in Antarctic soils. The research found that NO3- concentrations and isotopic values were consistent across the latitudinal gradient, with the majority of NO3- derived from nitrification process. Atmospheric deposition contributed minimally to the NO3- budget, and there was evidence of denitrification and cycling between NO3- and nitrite (NO2-). These findings provide new insights into the nitrogen cycle in Antarctic terrestrial ecosystems.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2023)
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)