Reactive Oxygen Species in the Immune System

Mitochondrial-mediated antiviral immunity

(2012) Takumi Koshiba   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91phox expression and the PARP-1/PAR pathway of apoptosis

(2012) J. Aurelius et al.   BLOOD

Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+ CD25+ FoxP3+ Tregs from CD4+ CD25− FoxP3− T cells

(2012) Sara M. Centuori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vivo immunoregulatory properties of the novel mitochondria-targeted antioxidant SkQ1

(2012) Yuhui Yang et al.   MOLECULAR IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

H2O2 production within tumor microenvironment inversely correlated with infiltration of CD56dim NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction

(2011) Shinichirou Izawa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Highly reactive oxygen species: detection, formation, and possible functions

(2011) Wolfhardt Freinbichler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neutrophil extracellular traps

(2011) Borko Amulic et al.   CURRENT BIOLOGY

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

NK cells: immune cross-talk and therapeutic implications

(2011) Anshu Malhotra et al.   Immunotherapy

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells

(2011) Y. Huang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

(2011) Olga Efimova et al.   PLoS One

Redox Remodeling Allows and Controls B-Cell Activation and Differentiation

(2010) Roberta Vené et al.   ANTIOXIDANTS & REDOX SIGNALING

B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses

(2010) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites

(2010) M. Brune et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

(2010) Adam J. Case et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin-Mediated Immunosuppression

(2010) M. M. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species Level Defines Two Functionally Distinctive Stages of Inflammatory Dendritic Cell Development from Mouse Bone Marrow

(2010) K.-C. Sheng et al.   JOURNAL OF IMMUNOLOGY

Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma+vaccination model

(2010) Wentao Jia et al.   JOURNAL OF NEUROIMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

TLR 9 Activation in Dendritic Cells Enhances Salmonella Killing and Antigen Presentation via Involvement of the Reactive Oxygen Species

(2010) Amit Lahiri et al.   PLoS One

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

(2010) Grace Y. Lam et al.   Seminars in Immunopathology

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

7β-hydroxycholesterol induces natural killer cell death via oxidative lysosomal destabilization

(2009) Wei Li et al.   FREE RADICAL RESEARCH

Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-κB and the generation of reactive oxygen species

(2009) Nanako Ogasawara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oxidative stress can alter the antigenicity of immunodominant peptides

(2009) Daniela Weiskopf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protective role of ROS in autoimmune disease

(2009) Malin Hultqvist et al.   TRENDS IN IMMUNOLOGY

NK cell apoptosis in coronary artery disease

(2008) Wei Li et al.   ATHEROSCLEROSIS

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death

(2008) D. Mougiakakos et al.   BLOOD

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells

(2008) David W. Chan et al.   CARCINOGENESIS

Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor

(2008) C. L-L. Chiang et al.   CLINICAL CANCER RESEARCH

Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions

(2008) Annalisa Del Prete et al.   FREE RADICAL BIOLOGY AND MEDICINE

Determination of T-cell fate by dendritic cells

(2008) Sandra S Diebold   IMMUNOLOGY AND CELL BIOLOGY

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

ETosis: A Novel Cell Death Pathway

(2008) F. Wartha et al.   Science Signaling

Nox enzymes in immune cells

(2008) William M. Nauseef   Seminars in Immunopathology

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH