An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

(2019) Young J. Yauger et al.   Journal of Neuroinflammation

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

(2019) Kyria M. Webster et al.   EXPERIMENTAL NEUROLOGY

Neutrophils and redox stress in the pathogenesis of autoimmune disease

(2018) Laurence Glennon-Alty et al.   FREE RADICAL BIOLOGY AND MEDICINE

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

(2018) Markus H. Hoffmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats

(2018) Jacqueline R. Kulbe et al.   JOURNAL OF NEUROTRAUMA

Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach

(2018) Fawad-Ali Shah et al.   NEUROCHEMICAL RESEARCH

Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography

(2018) Toshimitsu Okamura et al.   PHYTOMEDICINE

NADPH oxidases in traumatic brain injury – Promising therapeutic targets?

(2018) Merry W. Ma et al.   Redox Biology

Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury

(2018) Hong-Mei Zhang et al.   Drug Design Development and Therapy

Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury

(2017) Jing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

(2017) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

(2017) Raghavendar Chandran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

(2017) James P. Barrett et al.   Journal of Neuroinflammation

Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury

(2017) Yan Feng et al.   NEUROCHEMICAL RESEARCH

Apocynin protects against neurological damage induced by quinolinic acid by an increase in glutathione synthesis and Nrf2 levels

(2017) Silvia Cruz-Álvarez et al.   NEUROSCIENCE

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2–ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice

(2015) Darren M. Miller et al.   EXPERIMENTAL NEUROLOGY

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

(2015) Kyria M. Webster et al.   Journal of Neuroinflammation

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury

(2014) Xin-Yu Lu et al.   NEUROCHEMISTRY INTERNATIONAL

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Lung Health and Disease

(2013) Karen Bernard et al.   ANTIOXIDANTS & REDOX SIGNALING

Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion

(2013) Sandy R Shultz et al.   Journal of Neuroinflammation

Apocynin: Chemical and Biophysical Properties of a NADPH Oxidase Inhibitor

(2013) Maicon Petrônio et al.   MOLECULES

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: Role of inflammatory and oxidative brain damage

(2013) Ana Paula Oliveira Ferreira et al.   NEUROCHEMISTRY INTERNATIONAL

NOX Inhibitors as a Therapeutic Strategy for Stroke and Neurodegenerative Disease

(2012) Belinda Cairns et al.   CURRENT DRUG TARGETS

A CD11d Monoclonal Antibody Treatment Reduces Tissue Injury and Improves Neurological Outcome after Fluid Percussion Brain Injury in Rats

(2012) Feng Bao et al.   JOURNAL OF NEUROTRAUMA

Attenuation of brain edema and spatial learning deficits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats

(2012) SI-XIN SONG et al.   Molecular Medicine Reports

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

(2012) Quan-Guang Zhang et al.   PLoS One

Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase

(2011) Mauricio Mora-Pale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Short-Duration Treatment with the Calpain Inhibitor MDL-28170 Does Not Protect Axonal Transport in an in Vivo Model of Traumatic Axonal Injury

(2011) Marek Ma et al.   JOURNAL OF NEUROTRAUMA

Nox2 Oxidase Activity Accounts for the Oxidative Stress and Vasomotor Dysfunction in Mouse Cerebral Arteries following Ischemic Stroke

(2011) T. Michael De Silva et al.   PLoS One

Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice

(2010) Hui Shen et al.   BRAIN RESEARCH

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

Antioxidant therapies for traumatic brain injury

(2010) Edward D. Hall et al.   Neurotherapeutics

Translating the oxidative stress hypothesis into the clinic: NOX versus NOS

(2009) Melanie E. Armitage et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mouse closed head injury model induced by a weight-drop device

(2009) Michael A Flierl et al.   Nature Protocols

Oxidative damage to neurons caused by the induction of microglial NADPH oxidase in encephalomyocarditis virus infection

(2009) Yasuhisa Ano et al.   NEUROSCIENCE LETTERS