Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants

(2012) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of Interleukin-1β Induced-Increase in Mouse Intestinal Permeability In Vivo

(2012) Rana Al-Sadi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A Novel Murine Model of Inflammatory Bowel Disease and Inflammation-Associated Colon Cancer with Ulcerative Colitis-Like Features

(2012) Laura P. Hale et al.   PLoS One

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidant enzymes induced by repeated intake of excess energy in the form of high-fat, high-carbohydrate meals are not sufficient to block oxidative stress in healthy lean individuals

(2011) Sangbin Lim et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

(2011) Seonmin Lee et al.   CELL RESEARCH

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis

(2011) Balu K. Chacko et al.   HEPATOLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin-Mediated Immunosuppression

(2010) M. M. Kaminski et al.   JOURNAL OF IMMUNOLOGY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

MitoQ administration prevents endotoxin-induced cardiac dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

(2009) Yoku Hayakawa et al.   GASTROENTEROLOGY

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohnʼs disease

(2009) Belén Beltrán et al.   INFLAMMATORY BOWEL DISEASES

FOXP3 and the regulation of Treg/Th17 differentiation

(2009) Steven F. Ziegler et al.   MICROBES AND INFECTION

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

(2009) Yutao Yan et al.   PLoS One

HIF-1  regulates epithelial inflammation by cell autonomous NF B activation and paracrine stromal remodeling

(2008) M. Scortegagna et al.   BLOOD

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

Murine TNFΔARE Crohnʼs disease model displays diminished expression of intestinal Ca2+ transporters

(2008) Sylvie Huybers et al.   INFLAMMATORY BOWEL DISEASES

Inflammatory bowel disease, past, present and future: lessons from animal models

(2008) Atsushi Mizoguchi et al.   JOURNAL OF GASTROENTEROLOGY