Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

(2018) Tomas Gutiérrez et al.   CELL CALCIUM

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

(2018) Osamah Thaher et al.   NEUROCHEMISTRY INTERNATIONAL

Protein S-glutathionylation alters superoxide/hydrogen peroxide emission from pyruvate dehydrogenase complex

(2017) Marisa O’Brien et al.   FREE RADICAL BIOLOGY AND MEDICINE

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Cysteines as Redox Molecular Switches and Targets of Disease

(2017) Annamaria Fra et al.   Frontiers in Molecular Neuroscience

Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?

(2017) Maria Sol Herrera-Cruz et al.   Frontiers in Oncology

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System

(2017) Celien Lismont et al.   ANTIOXIDANTS & REDOX SIGNALING

HyPer Family Probes: State of the Art

(2016) Dmitry S. Bilan et al.   ANTIOXIDANTS & REDOX SIGNALING

Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival

(2016) Iria Medraño-Fernandez et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels

(2016) Sabrina Mindthoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

No peroxisome is an island — Peroxisome contact sites

(2016) Nadav Shai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial disulfide relay and its substrates: mechanisms in health and disease

(2016) Alican J. Erdogan et al.   CELL AND TISSUE RESEARCH

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

(2016) Christian Appenzeller-Herzog et al.   FREE RADICAL BIOLOGY AND MEDICINE

Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress

(2016) Jie Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+flux

(2016) Arun Raturi et al.   JOURNAL OF CELL BIOLOGY

AQP8 transports NOX2-generated H 2 O 2 across the plasma membrane to promote signaling in B cells

(2016) Milena Bertolotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis

(2016) Jinjiang Fan et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Redox-assisted regulation of Ca2+homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5

(2016) Ryo Ushioda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

(2016) Amy E. M. Beedle et al.   Nature Communications

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

(2015) J. Kirstein et al.   EMBO JOURNAL

A PDI-catalyzed thiol–disulfide switch regulates the production of hydrogen peroxide by human Ero1

(2015) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteostasis and “redoxtasis” in the secretory pathway: Tales of tails from ERp44 and immunoglobulins

(2015) Tiziana Anelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

The antioxidant machinery of the endoplasmic reticulum: Protection and signaling

(2015) Agnès Delaunay-Moisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative protein folding: From thiol–disulfide exchange reactions to the redox poise of the endoplasmic reticulum

(2015) Devin A. Hudson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome–Mitochondria Interactions through the ERMES Complex

(2015) M. Mattiazzi Ušaj et al.   JOURNAL OF MOLECULAR BIOLOGY

Cysteine-mediated redox signalling in the mitochondria

(2015) D. W. Bak et al.   Molecular BioSystems

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

(2015) Emilie Hangen et al.   MOLECULAR CELL

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of apoptosis-inducing factor critically affects MIA40 function

(2015) K Meyer et al.   Cell Death & Disease

Nox NADPH Oxidases and the Endoplasmic Reticulum

(2014) Francisco R.M. Laurindo et al.   ANTIOXIDANTS & REDOX SIGNALING

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity

(2014) Marianna Marino et al.   HUMAN MOLECULAR GENETICS

Redox controls UPR to control redox

(2014) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Peroxisomes are juxtaposed to strategic sites on mitochondria

(2014) Yifat Cohen et al.   Molecular BioSystems

Response to Marinelli and Marchissio

(2013) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Tyrosine Kinase Signal Modulation: A Matter of H2O2 Membrane Permeability?

(2013) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Genetically encoded fluorescent redox sensors

(2013) Konstantin A. Lukyanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metabolic functions of peroxisomes in health and disease

(2013) Ronald J.A. Wanders   BIOCHIMIE

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

An ER-peroxisome tether exerts peroxisome population control in yeast

(2013) Barbara Knoblach et al.   EMBO JOURNAL

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidant Sensing by Reversible Disulfide Bond Formation

(2013) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling

(2013) E. M. Lynes et al.   JOURNAL OF CELL SCIENCE

ERdj5 Is the ER Reductase that Catalyzes the Removal of Non-Native Disulfides and Correct Folding of the LDL Receptor

(2013) Ojore Benedict Valentine Oka et al.   MOLECULAR CELL

Mitochondrial Hyperfusion during Oxidative Stress Is Coupled to a Dysregulation in Calcium Handling within a C2C12 Cell Model

(2013) Calum J. Redpath et al.   PLoS One

Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction

(2012) I. Hwang et al.   DIABETES

Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state

(2012) Kerstin Kojer et al.   EMBO JOURNAL

The intracellular redox state is a core determinant of mitochondrial fusion

(2012) Timothy Shutt et al.   EMBO REPORTS

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

(2012) Bidur Bhandary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone

(2012) Magdalena Bartoszewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProteinS-glutathionylation enhances Ca2+-induced Ca2+release via the IP3receptor in cultured aortic endothelial cells

(2012) Jeffrey T. Lock et al.   JOURNAL OF PHYSIOLOGY-LONDON

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Protein glutathionylation in cellular compartments: A constitutive redox signal

(2012) Stefania Petrini et al.   REDOX REPORT

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

(2012) T. Finkel   Science Signaling

Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

(2012) Maria Julia Marchissio et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Peroxides and Peroxidases in the Endoplasmic Reticulum: Integrating Redox Homeostasis and Oxidative Folding

(2011) Taichi Kakihana et al.   ANTIOXIDANTS & REDOX SIGNALING

Low-Molecular-Weight Oxidants Involved in Disulfide Bond Formation

(2011) Lloyd W. Ruddock   ANTIOXIDANTS & REDOX SIGNALING

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation

(2011) Yuuta Ukai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The human geneSLC25A17encodes a peroxisomal transporter of coenzyme A, FAD and NAD+

(2011) Gennaro Agrimi et al.   BIOCHEMICAL JOURNAL

Transfer of metabolites across the peroxisomal membrane

(2011) Vasily D. Antonenkov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

(2011) Emily M. Lynes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy

(2011) Jian-Hua Li et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Hydrogen Peroxide Probes Directed to Different Cellular Compartments

(2011) Mikalai Malinouski et al.   PLoS One

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)

(2010) Thomas Simmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ero1α requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)

(2010) Susanna Y. Gilady et al.   CELL STRESS & CHAPERONES

De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p

(2010) Robert Rucktäschel et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Fluorescent Sensor Protein for Visualization of Redox States in the Cytoplasm and in Peroxisomes

(2010) T. Yano et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Modulating Proteostasis: Peptidomimetic Inhibitors and Activators of Protein Folding

(2009) Feras Hatahet et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biogenesis of peroxisomes and mitochondria: linked by division

(2009) Hannah K. Delille et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses

(2009) Diane E. Handy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1

(2009) H.-R. Kim et al.   JOURNAL OF CELL SCIENCE

Green fluorescent proteins are light-induced electron donors

(2009) Alexey M Bogdanov et al.   Nature Chemical Biology

Pxmp2 Is a Channel-Forming Protein in Mammalian Peroxisomal Membrane

(2009) Aare Rokka et al.   PLoS One

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Contribution of Peroxisome-specific Isoform of Lon Protease in Sorting PTS1 Proteins to Peroxisomes

(2008) S. Omi et al.   JOURNAL OF BIOCHEMISTRY

Peroxisome Deficiency Causes a Complex Phenotype because of Hepatic SREBP/Insig Dysregulation Associated with Endoplasmic Reticulum Stress

(2008) Werner J. Kovacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Dynamics in the Peroxisomal Lumen of Living Cells

(2008) Ilaria Drago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preventing hypoxia/reoxygenation damage to hepatocytes by p66shc ablation: Up-regulation of anti-oxidant and anti-apoptotic proteins

(2008) Sanae Haga et al.   JOURNAL OF HEPATOLOGY

Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex

(2008) R. Bull et al.   JOURNAL OF NEUROSCIENCE

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

(2008) Nathan Myhill et al.   MOLECULAR BIOLOGY OF THE CELL

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

(2008) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE