APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase

(2016) Jung Hee Joo et al.   Scientific Reports

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

(2015) J. Mark Brown et al.   Annual Review of Medicine

Nox and renal disease

(2015) Chet E. Holterman et al.   CLINICAL SCIENCE

Are reactive oxygen species still the basis for diabetic complications?

(2015) Elyse Di Marco et al.   CLINICAL SCIENCE

NADPH oxidase 5 and renal disease

(2015) Chet E. Holterman et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney

(2015) Kai Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice

(2015) Hajime Nagasu et al.   LABORATORY INVESTIGATION

Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms

(2015) Simona-Adriana Manea et al.   Redox Biology

Oxidative Stress and Organ Damages

(2014) Sayoko Ogura et al.   CURRENT HYPERTENSION REPORTS

Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma

(2014) Jinah Choi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endotoxemia in End-Stage Kidney Disease

(2014) Jonathan Wong et al.   SEMINARS IN DIALYSIS

The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling

(2014) Kohei Uchimura et al.   Nature Communications

Probucol Inhibited Nox2 Expression and Attenuated Podocyte Injury in Type 2 Diabetic Nephropathy of db/db Mice

(2013) Guangyu Zhou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells

(2013) Jee Hyun Lee et al.   CARDIOVASCULAR RESEARCH

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Nox as a target for diabetic complications

(2013) Yves Gorin et al.   CLINICAL SCIENCE

Valsartan slows the progression of diabetic nephropathy indb/dbmice via a reduction in podocyte injury, and renal oxidative stress and inflammation

(2013) Guangyu Zhou et al.   CLINICAL SCIENCE

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice

(2013) E. Di Marco et al.   DIABETOLOGIA

Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice

(2013) J. J. Cha et al.   ENDOCRINOLOGY

Thioredoxin-interacting Protein Mediates High Glucose-induced Reactive Oxygen Species Generation by Mitochondria and the NADPH Oxidase, Nox4, in Mesangial Cells

(2013) Anu Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression

(2013) C. E. Holterman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice

(2013) Jung Eun Kim et al.   PLoS One

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet

(2012) Jennifer K. Pepping et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

Role of Nox4 in murine models of kidney disease

(2012) Andrea Babelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections

(2012) A. Pizzolla et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Potentiation by candesartan of protective effects of pioglitazone against type 2 diabetic cardiovascular and renal complications in obese mice

(2010) Masaya Fukuda et al.   JOURNAL OF HYPERTENSION

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

(2009) G. Y. Oudit et al.   DIABETES

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

(2008) Katrin Schröder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES