The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Intensifying Insulin Therapy: What Options Are Available to Patients with Type 2 Diabetes?

(2013) Luigi F. Meneghini   AMERICAN JOURNAL OF MEDICINE

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC

(2013) Hemang Patel et al.   Cardiovascular Diabetology

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet

(2013) Alejandra Espinosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion

(2013) Maria Fernanda Graciano et al.   Islets

NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness

(2012) Xiangdong Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

(2012) N. Li et al.   DIABETES

Diabetes: Have We Got It All Wrong?: Insulin hypersecretion and food additives: cause of obesity and diabetes?

(2012) B. E. Corkey   DIABETES CARE

Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

(2012) Y Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion

(2012) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice

(2012) Zi-Feng Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Expression of NADPH oxidase in human pancreatic islets

(2012) Eduardo Rebelato et al.   LIFE SCIENCES

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

(2012) Jessica R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation

(2011) Ismail Syed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

miR-146a is modulated in human endothelial cell with aging

(2011) Mariuca Vasa-Nicotera et al.   ATHEROSCLEROSIS

The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?

(2011) Ina Takac et al.   CURRENT HYPERTENSION REPORTS

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

(2011) Ismail Syed et al.   DIABETES

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

(2011) K. Raddatz et al.   DIABETOLOGIA

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

(2011) JennaLynn Styskal et al.   FREE RADICAL BIOLOGY AND MEDICINE

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of NADPH Oxidase Activity Is Associated with miRNA-25-Mediated NOX4 Expression in Experimental Diabetic Nephropathy

(2010) Yibing Fu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic β-cells

(2010) Ismail Syed et al.   BIOCHEMICAL PHARMACOLOGY

Improvement of Insulin Resistance by Removal of Systemic Hydrogen Peroxide by PEGylated Catalase in Obese Mice

(2010) Mai Ikemura et al.   MOLECULAR PHARMACEUTICS

Association of NAD(P)H Oxidase with Glucose-Induced Insulin Secretion by Pancreatic β-Cells

(2009) D. Morgan et al.   ENDOCRINOLOGY

Effects of pyridoxamine (K-163) on glucose intolerance and obesity in high-fat diet C57BL/6J mice

(2009) Shinji Hagiwara et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

(2009) Grégory Lacraz et al.   PLoS One

Low Revascularization of Human Islets When Experimentally Transplanted Into the Liver

(2009) Joey Lau et al.   TRANSPLANTATION

Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet

(2008) Eric L. Kendig et al.   BIOCHEMICAL PHARMACOLOGY

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

(2008) Cécile Guichard et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired Insulin Secretion by Diphenyleneiodium Associated with Perturbation of Cytosolic Ca2+Dynamics in Pancreatic β-Cells

(2008) Hirofumi Imoto et al.   ENDOCRINOLOGY

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

(2008) Naoto Matsuzawa-Nagata et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data

(2008) Rebecca J Brown et al.   PEDIATRIC DIABETES