- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting mitochondrial ion channels for cancer therapy
Authors
Keywords
Mitochondria, Ion channels, Cancer, Drug targeting, Channel interactions
Journal
Redox Biology
Volume -, Issue -, Pages 101846
Publisher
Elsevier BV
Online
2020-12-25
DOI
10.1016/j.redox.2020.101846
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons
- (2020) Ivana Savic Azoulay et al. JOURNAL OF NEUROCHEMISTRY
- Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent
- (2020) Arthur G Mikaelian et al. Drug Design Development and Therapy
- Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells
- (2020) Flavien Bermont et al. Nutrients
- A High-Throughput Screening Identifies MICU1 Targeting Compounds
- (2020) Giulia Di Marco et al. Cell Reports
- Intracellular Chloride Channels: Novel Biomarkers in Diseases
- (2020) Shubha Gururaja Rao et al. Frontiers in Physiology
- Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy
- (2020) Luigi Ippolito et al. Frontiers in Oncology
- Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells
- (2020) Francesco Ciscato et al. EMBO REPORTS
- Immunomodulatory significance of natural peptides in mammalians: Promising agents for medical application
- (2020) Jinyang Cai et al. IMMUNOBIOLOGY
- Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex
- (2020) Minrui Fan et al. NATURE
- The Mitochondrial Calcium Uniporter Interacts with Subunit c of the ATP Synthase of Trypanosomes and Humans
- (2020) Guozhong Huang et al. mBio
- Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response
- (2020) Devasena Ponnalagu et al. Frontiers in Physiology
- Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis
- (2020) Alessandro Rimessi et al. Science Advances
- Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents
- (2020) Ileana Hernández-Reséndiz et al. Cancers
- Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines
- (2020) Anna Lucia Tornesello et al. Cancers
- Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery
- (2020) Volker Herzig et al. BIOCHEMICAL PHARMACOLOGY
- The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides
- (2020) Gabor Tajti et al. BIOCHEMICAL PHARMACOLOGY
- Targeting putative components of the mitochondrial permeability transition pore for novel therapeutics
- (2020) Raymond J. Winquist et al. BIOCHEMICAL PHARMACOLOGY
- Mitochondrial Metabolism as a Target for Cancer Therapy
- (2020) Karthik Vasan et al. Cell Metabolism
- Multifaceted Roles of Mitochondrial Components and Metabolites in Metabolic Diseases and Cancer
- (2020) Jean Nakhle et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection
- (2020) Michela Carraro et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ca2+ Fluxes and Cancer
- (2020) Saverio Marchi et al. MOLECULAR CELL
- ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer
- (2020) Gan Huang et al. Oxidative Medicine and Cellular Longevity
- NCLX prevents cell death during adrenergic activation of the brown adipose tissue
- (2020) Essam A. Assali et al. Nature Communications
- Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter
- (2020) Yan Wang et al. eLife
- Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer
- (2020) Alexis Díaz-García et al. Frontiers in Pharmacology
- Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology
- (2020) Massimo Bonora et al. Biomolecules
- Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies
- (2020) Yuting Cui et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Cryo-EM structure of the entire mammalian F-type ATP synthase
- (2020) Gergely Pinke et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mitochondrial F-ATP synthase as the permeability transition pore
- (2020) Christoph Gerle PHARMACOLOGICAL RESEARCH
- Cell-penetrating peptides in oncologic pharmacotherapy: A review
- (2020) Nuno Vale et al. PHARMACOLOGICAL RESEARCH
- Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
- (2020) Roberta Peruzzo et al. Redox Biology
- Mitochondrial Metabolism, Contact Sites and Cellular Calcium Signaling: Implications for Tumorigenesis
- (2020) Roberta Peruzzo et al. Cancers
- Mitochondrial Potassium Channels as Druggable Targets
- (2020) Antoni Wrzosek et al. Biomolecules
- KB-R7943 Inhibits the Mitochondrial Ca2+ Uniporter but Not Na+–Ca2+ Exchanger in Cardiomyocyte-Derived H9c2 Cells
- (2020) Iyuki Namekata et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury
- (2019) Joshua J. Woods et al. ACS Central Science
- High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)
- (2019) Saverio Marchi et al. CELL CYCLE
- Mitochondrial Megachannel Resides in Monomeric ATP Synthase
- (2019) Nelli Mnatsakanyan et al. BIOPHYSICAL JOURNAL
- Mitochondria-targeted triphenylphosphonium conjugated glycyrrhetinic acid derivatives as potent anticancer drugs
- (2019) Le Jin et al. BIOORGANIC CHEMISTRY
- Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment
- (2019) Chaochu Cui et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mitochondrial calcium uniporter complex modulation in cancerogenesis
- (2019) Saverio Marchi et al. CELL CYCLE
- Triphenylphosphonium Analogues of Betulin and Betulinic Acid with Biological Activity: A Comprehensive Review
- (2019) Mirosława Grymel et al. JOURNAL OF NATURAL PRODUCTS
- The Mitochondrial Permeability Transition in Mitochondrial Disorders
- (2019) Justina Šileikytė et al. Oxidative Medicine and Cellular Longevity
- Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
- (2019) Anna Hordyjewska et al. PHYTOCHEMISTRY REVIEWS
- The Mitochondrion as an Emerging Therapeutic Target in Cancer
- (2019) Katherine G. Roth et al. TRENDS IN MOLECULAR MEDICINE
- Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
- (2019) Gang Cheng et al. Nature Communications
- Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells
- (2019) Christopher Nguyen et al. Cancers
- Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity
- (2019) Zheng Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Second‐Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability
- (2019) Justina Šileikytė et al. ChemMedChem
- Identification of an ATP-sensitive potassium channel in mitochondria
- (2019) Angela Paggio et al. NATURE
- Phage Display: Simple Evolution in a Petri Dish (Nobel Lecture)
- (2019) George P. Smith ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Harnessing Evolution to Make Medicines (Nobel Lecture)
- (2019) Gregory Winter ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mitochondrion-Targeting Peptides and Peptidomimetics: Recent Progress and Design Principles
- (2019) Soyoung Kim et al. BIOCHEMISTRY
- Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
- (2019) Lucia Biasutto et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cell penetrating peptides: the potent multi-cargo intracellular carriers
- (2019) Kimia Kardani et al. Expert Opinion on Drug Delivery
- Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII
- (2019) Yongjian Guo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels
- (2019) León-Aparicio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel
- (2019) Michał Laskowski et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
- (2019) Mark F. van Delft et al. Nature Chemical Biology
- Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore
- (2019) Andrea Urbani et al. Nature Communications
- Targeting mitochondria as an anticancer strategy
- (2019) Lanfeng Dong et al. Cancer Communications
- Expression and Function of Host Defense Peptides at Inflammation Sites
- (2019) Suhanya V. Prasad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A novel class of cardioprotective small-molecule PTP inhibitors
- (2019) Salvatore Antonucci et al. PHARMACOLOGICAL RESEARCH
- VDAC1 functions in Ca 2+ homeostasis and cell life and death in health and disease
- (2018) Varda Shoshan-Barmatz et al. CELL CALCIUM
- The Potential Use of Peptides in Cancer Treatment
- (2018) Bahram Yavari et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells
- (2018) Glenn R. Bantug et al. IMMUNITY
- Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application
- (2018) Ana Seca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Control of mitochondrial superoxide production by reverse electron transport at complex I
- (2018) Ellen L. Robb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy
- (2018) Anna Shteinfer-Kuzmine et al. Molecular Oncology
- Mitochondrial Targeted Doxorubicin-Triphenylphosphonium Delivered by Hyaluronic Acid Modified and pH Responsive Nanocarriers to Breast Tumor: in Vitro and in Vivo Studies
- (2018) Hui-Na Liu et al. MOLECULAR PHARMACEUTICS
- Mitochondrial permeability transition pore: Back to the drawing board
- (2018) Christos Chinopoulos NEUROCHEMISTRY INTERNATIONAL
- The role of the mitochondrial calcium uniporter (MCU) complex in cancer
- (2018) Adina Vultur et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells
- (2018) Rong Zhang et al. Cell Death & Disease
- Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide
- (2018) Srinivas Pittala et al. NEOPLASIA
- A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
- (2018) Balaraman Kalyanaraman et al. Redox Biology
- Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents
- (2018) Andrea Mattarei et al. Frontiers in Oncology
- Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming
- (2018) Zhongfu Ying et al. Cell Metabolism
- Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels
- (2018) Shreya S. Bellampalli et al. PAIN
- Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment
- (2018) Gantumur Battogtokh et al. Frontiers in Pharmacology
- Pharmacological modulation of mitochondrial ion channels
- (2018) Luigi Leanza et al. BRITISH JOURNAL OF PHARMACOLOGY
- Modulating ROS to overcome multidrug resistance in cancer
- (2018) Qingbin Cui et al. DRUG RESISTANCE UPDATES
- Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1
- (2018) Ya-Nan Xue et al. EXPERIMENTAL CELL RESEARCH
- Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
- (2018) Alfredo Cabrera-Orefice et al. Nature Communications
- Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93AhSOD1 mice
- (2018) Vedrana Tadić et al. NEUROBIOLOGY OF AGING
- Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
- (2017) Abiy D. Woldetsadik et al. FASEB JOURNAL
- Disrupting mitochondrial Ca2+ homeostasis causes tumor-selective TRAIL sensitization through mitochondrial network abnormalities
- (2017) Yohei Ohshima et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Versatile Roles of Intracellularly Located TRPV1 Channel
- (2017) Rui Zhao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Affinity chromatographic methodologies based on immobilized voltage dependent anion channel isoform 1 and application in protein-ligand interaction analysis and bioactive compounds screening from traditional medicine
- (2017) Qian Li et al. JOURNAL OF CHROMATOGRAPHY A
- Protein–protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms
- (2017) Marianna Caterino et al. Molecular BioSystems
- Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
- (2017) Daniela M. Arduino et al. MOLECULAR CELL
- Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes
- (2017) Amit Agarwal et al. NEURON
- Venom-derived peptide inhibitors of voltage-gated potassium channels
- (2017) Raymond S. Norton et al. NEUROPHARMACOLOGY
- Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells
- (2017) Elisa Venturini et al. NEUROSIGNALS
- MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells
- (2017) T Ren et al. ONCOGENE
- Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells
- (2017) Daniel Bauer et al. Cell Death & Disease
- Mitochondrial VDAC1-based peptides: Attacking oncogenic properties in glioblastoma
- (2017) Anna Shteinfer-Kuzmine et al. Oncotarget
- Enhanced Mitochondrial Transient Receptor Potential Channel, Canonical Type 3–Mediated Calcium Handling in the Vasculature From Hypertensive Rats
- (2017) Bin Wang et al. Journal of the American Heart Association
- Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
- (2017) Amadou K. S. Camara et al. Frontiers in Physiology
- Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview
- (2017) Raheleh Roudi et al. Frontiers in Immunology
- Targeting calcium signaling in cancer therapy
- (2017) Chaochu Cui et al. Acta Pharmaceutica Sinica B
- Endoplasmic Reticulum–Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target
- (2017) Galdo Bustos et al. Frontiers in Oncology
- Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria
- (2016) Sae Rin Jean et al. ACCOUNTS OF CHEMICAL RESEARCH
- Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines
- (2016) Silvia Grancara et al. AMINO ACIDS
- The Hallmarks of Cancer from a Redox Perspective
- (2016) Marten Hornsveld et al. ANTIOXIDANTS & REDOX SIGNALING
- Structure and function of mitochondrial complex I
- (2016) Christophe Wirth et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- VDAC2-specific cellular functions and the underlying structure
- (2016) Shamim Naghdi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Natural and synthetic flavonoid modulation of TRPC5 channels
- (2016) Jacqueline Naylor et al. BRITISH JOURNAL OF PHARMACOLOGY
- The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α
- (2016) Anna Tosatto et al. EMBO Molecular Medicine
- Pyr3, a TRPC3 channel blocker, potentiates dexamethasone sensitivity and apoptosis in acute lymphoblastic leukemia cells by disturbing Ca2+ signaling, mitochondrial membrane potential changes and reactive oxygen species production
- (2016) Souleymane Abdoul-Azize et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Delivery of drugs and macromolecules to the mitochondria for cancer therapy
- (2016) Phong Lu et al. JOURNAL OF CONTROLLED RELEASE
- Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria
- (2016) Christopher Weidner et al. JOURNAL OF NATURAL PRODUCTS
- Molecular identity of cardiac mitochondrial chloride intracellular channel proteins
- (2016) Devasena Ponnalagu et al. MITOCHONDRION
- Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
- (2016) Stepana Boukalova et al. MOLECULAR CANCER THERAPEUTICS
- Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis
- (2016) A Bigi et al. ONCOGENE
- Size-dependent forced PEG partitioning into channels: VDAC, OmpC, and α-hemolysin
- (2016) M. Alphan Aksoyoglu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux
- (2016) Zhou Long et al. Oncotarget
- Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma
- (2016) Angela Zaccagnino et al. Oncotarget
- VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications
- (2016) Simona Reina et al. Oncotarget
- VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology
- (2016) Simona Reina et al. Frontiers in Oncology
- Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines
- (2016) Ilya Kovalenko et al. PLoS One
- Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis
- (2015) Jaroslav Truksa et al. ANTIOXIDANTS & REDOX SIGNALING
- Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
- (2015) Debanjan Tewari et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The mitochondrial voltage-dependent anion channel 1 in tumor cells
- (2015) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Structure and function of the mitochondrial calcium uniporter complex
- (2015) Diego De Stefani et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Identification of a Mitochondrial-Binding Site on the Amino-Terminal End of Hexokinase II
- (2015) Nadezda Bryan et al. BIOSCIENCE REPORTS
- Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner
- (2015) Bing Yan et al. BMC CANCER
- Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca2+-activated K+channels
- (2015) Y C Xu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection
- (2015) Lara Testai et al. CARDIOVASCULAR RESEARCH
- Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
- (2015) Josephine Modica-Napolitano et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells
- (2015) Li Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway
- (2015) WEI ZHAO et al. Molecular Medicine Reports
- In Silico Identification of PAP-1 Binding Sites in the Kv1.2 Potassium Channel
- (2015) Christian Jorgensen et al. MOLECULAR PHARMACEUTICS
- Gold(III)-pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents
- (2015) Chiara Nardon et al. ChemistryOpen
- Improving the Efficacy of Plant Polyphenols
- (2014) Lucia Biasutto et al. Anti-Cancer Agents in Medicinal Chemistry
- Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells
- (2014) Dénes Nagy et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- The mitochondrial permeability transition pore and its adaptive responses in tumor cells
- (2014) Andrea Rasola et al. CELL CALCIUM
- Correlation between Potassium Channel Expression and Sensitivity to Drug-induced Cell Death in Tumor Cell Lines
- (2014) Luigi Leanza et al. CURRENT PHARMACEUTICAL DESIGN
- Electroreductive Dimerization of Coumarin and Coumarin Analogues at Carbon Cathodes
- (2014) Erick M. Pasciak et al. JOURNAL OF ORGANIC CHEMISTRY
- Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique
- (2014) Angela Messina et al. Molecular BioSystems
- MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity
- (2014) Maria Patron et al. MOLECULAR CELL
- Mitochondrial Channels: Ion Fluxes and More
- (2014) Ildiko Szabo et al. PHYSIOLOGICAL REVIEWS
- Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
- (2014) Dmitry B. Zorov et al. PHYSIOLOGICAL REVIEWS
- CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
- (2014) A Ruiz et al. Cell Death & Disease
- Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
- (2014) H Huang et al. Cell Death & Disease
- Targeted Delivery of Doxorubicin to Mitochondria
- (2013) Graham R. Chamberlain et al. ACS Chemical Biology
- Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate
- (2013) Lubomir Prochazka et al. APOPTOSIS
- Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction
- (2013) Amalia M. Dolga et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potassium Channel in the Mitochondria of Human Keratinocytes
- (2013) Renata Toczyłowska-Mamińska et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Modulation of oxidative stress as an anticancer strategy
- (2013) Chiara Gorrini et al. NATURE REVIEWS DRUG DISCOVERY
- Dimers of mitochondrial ATP synthase form the permeability transition pore
- (2013) V. Giorgio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
- (2013) N Rimmerman et al. Cell Death & Disease
- VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia
- (2013) T Prezma et al. Cell Death & Disease
- Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms
- (2012) Nicola Sassi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue
- (2012) Sara Rodríguez-Enríquez et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Cannabidiol as potential anticancer drug
- (2012) Paola Massi et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Expression of a Truncated Active Form of VDAC1 in Lung Cancer Associates with Hypoxic Cell Survival and Correlates with Progression to Chemotherapy Resistance
- (2012) M. C. Brahimi-Horn et al. CANCER RESEARCH
- Mitochondrial ROMK Channel Is a Molecular Component of MitoK ATP
- (2012) D. Brian Foster et al. CIRCULATION RESEARCH
- Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels
- (2012) L. Leanza et al. CURRENT MEDICINAL CHEMISTRY
- Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
- (2012) Luigi Leanza et al. EMBO Molecular Medicine
- High efficiency versus maximal performance — The cause of oxidative stress in eukaryotes: A hypothesis
- (2012) Bernhard Kadenbach et al. MITOCHONDRION
- Classification of mitocans, anti-cancer drugs acting on mitochondria
- (2012) Jiri Neuzil et al. MITOCHONDRION
- Mitochondria as sensors and regulators of calcium signalling
- (2012) Rosario Rizzuto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death
- (2012) F Chiara et al. Cell Death & Disease
- Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain
- (2011) Jakub Rohlena et al. ANTIOXIDANTS & REDOX SIGNALING
- Mitochondria-Targeted Small Molecule Therapeutics and Probes
- (2011) Robin A.J. Smith et al. ANTIOXIDANTS & REDOX SIGNALING
- VDAC isoforms in mammals
- (2011) Angela Messina et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
- (2011) D De Stefani et al. CELL DEATH AND DIFFERENTIATION
- Rerouting Chlorambucil to Mitochondria Combats Drug Deactivation and Resistance in Cancer Cells
- (2011) Sonali B. Fonseca et al. CHEMISTRY & BIOLOGY
- Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
- (2011) Craig A. Coburn et al. ChemMedChem
- Clofazimine: current status and future prospects
- (2011) M. C. Cholo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Single Channel Characterization of the Mitochondrial Ryanodine Receptor in Heart Mitoplasts
- (2011) Shin-Young Ryu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations
- (2011) Shana O. Kelley et al. PHARMACEUTICAL RESEARCH
- SLO-2 Is Cytoprotective and Contributes to Mitochondrial Potassium Transport
- (2011) Andrew P. Wojtovich et al. PLoS One
- Animal and human studies with the mitochondria-targeted antioxidant MitoQ
- (2010) Robin A.J. Smith et al. Annals of the New York Academy of Sciences
- Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis
- (2010) I Szabò et al. CELL DEATH AND DIFFERENTIATION
- Signal transduction to the permeability transition pore
- (2010) Andrea Rasola et al. FEBS LETTERS
- Mitochondrial potassium channels and reactive oxygen species
- (2010) Dominika Malinska et al. FEBS LETTERS
- Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II
- (2010) Lan-Feng Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrially targeted anti-cancer agents
- (2010) Lucia Biasutto et al. MITOCHONDRION
- Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis
- (2010) N. Keinan et al. MOLECULAR AND CELLULAR BIOLOGY
- VDAC, a multi-functional mitochondrial protein regulating cell life and death
- (2010) Varda Shoshan-Barmatz et al. MOLECULAR ASPECTS OF MEDICINE
- Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion
- (2010) P. I. Zimin et al. MOLECULAR PHARMACOLOGY
- Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
- (2010) X. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion
- (2009) Franziska B. Mullauer et al. APOPTOSIS
- Chloride intracellular channel 1 regulates osteoblast differentiation
- (2009) Jae-Yeon Yang et al. BONE
- Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells
- (2009) Umberto De Marchi et al. CELL CALCIUM
- Regulation of the Human Cardiac Mitochondrial Ca 2+ Uptake by 2 Different Voltage-Gated Ca 2+ Channels
- (2009) Guido Michels et al. CIRCULATION
- Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity
- (2009) Nir Arbel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
- (2009) Stephen J. Ralph et al. MOLECULAR ASPECTS OF MEDICINE
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax
- (2009) H Yamagata et al. ONCOGENE
- Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
- (2009) A. Rasola et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
- (2009) R. Palty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting lipophilic cations to mitochondria
- (2008) Michael P. Murphy BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase
- (2008) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- 4-Phenoxybutoxy-substituted heterocycles – A structure–activity relationship study of blockers of the lymphocyte potassium channel Kv1.3
- (2008) Silke B. Bodendiek et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of hexokinase binding to VDAC
- (2008) John G. Pastorino et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1
- (2008) Salah Abu-Hamad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity
- (2008) Laetitia Arzoine et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels
- (2008) Federica Chiara et al. PLoS One
- Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes
- (2008) Yunzhao R. Ren et al. PLoS One
- Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes
- (2008) I. Szabo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy
- (2008) Saroj P. Mathupala et al. SEMINARS IN CANCER BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now