Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment

Self-Assembled Coumarin Nanoparticle in Aqueous Solution as Selective Mitochondrial-Targeting Drug Delivery System

(2018) Ji Ha Lee et al.   ACS Applied Materials & Interfaces

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

(2018) Yanan Tan et al.   BIOMATERIALS

Dequalinium-based functional nanosomes show increased mitochondria targeting and anticancer effect

(2018) Yoonhee Bae et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria

(2018) Hongjian He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial Targeted Doxorubicin-Triphenylphosphonium Delivered by Hyaluronic Acid Modified and pH Responsive Nanocarriers to Breast Tumor: in Vitro and in Vivo Studies

(2018) Hui-Na Liu et al.   MOLECULAR PHARMACEUTICS

Triphenylphosphine-docetaxel conjugate-incorporated albumin nanoparticles for cancer treatment

(2018) Gantumur Battogtokh et al.   Nanomedicine

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

Photosensitizer-mediated mitochondria-targeting nanosized drug carriers: Subcellular targeting, therapeutic, and imaging potentials

(2017) Yeon Su Choi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polymeric nanoparticles: Promising platform for drug delivery

(2017) Khalid M. El-Say et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Functional nanosome for enhanced mitochondria-targeted gene delivery and expression

(2017) Yoonhee Bae et al.   MITOCHONDRION

Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

(2017) Ka Young Kim et al.   Nano Research

Mitochondrial-targeted photosensitizer-loaded folate-albumin nanoparticle for photodynamic therapy of cancer

(2017) Gantumur Battogtokh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Triphenyl Phosphine-Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria

(2017) Jiahui Hou et al.   Nanoscale Research Letters

Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo

(2017) Chao Zhang et al.   Small

Triphenyl Phosphine-Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria

(2017) Jiahui Hou et al.   Nanoscale Research Letters

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

(2017) Zhenjie Wang et al.   Asian Journal of Pharmaceutical Sciences

Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria

(2016) Sae Rin Jean et al.   ACCOUNTS OF CHEMICAL RESEARCH

Graphene oxide-incorporated pH-responsive folate-albumin-photosensitizer nanocomplex as image-guided dual therapeutics

(2016) Gantumur Battogtokh et al.   JOURNAL OF CONTROLLED RELEASE

Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization

(2016) Brittany Haynes et al.   Nanomedicine-Nanotechnology Biology and Medicine

A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy

(2016) Yanchun Wei et al.   Nanoscale

Conjugated 5-fluorouracil with mitochondria-targeting lipophilic cation: design, synthesis and biological evaluation

(2016) Jia Wang et al.   MedChemComm

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

(2016) Nicole A Seebacher et al.   Cell Death & Disease

Mitochondria targeting nano agents in cancer therapeutics

(2016) Xiao-Ying Zhang et al.   Oncology Letters

Dual Drug Conjugated Nanoparticle for Simultaneous Targeting of Mitochondria and Nucleus in Cancer Cells

(2015) Abhik Mallick et al.   ACS Applied Materials & Interfaces

Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer

(2015) Shaojuan Zhang et al.   Acta Biomaterialia

Triphenylphosphonium-Conjugated Poly(ε-caprolactone)-Based Self-Assembled Nanostructures as Nanosized Drugs and Drug Delivery Carriers for Mitochondria-Targeting Synergistic Anticancer Drug Delivery

(2015) Dong Youl Cho et al.   ADVANCED FUNCTIONAL MATERIALS

Dual-Stage-Light-Guided Tumor Inhibition by Mitochondria-Targeted Photodynamic Therapy

(2015) Kai Han et al.   ADVANCED FUNCTIONAL MATERIALS

Mitophagy induced by nanoparticle–peptide conjugates enabling an alternative intracellular trafficking route

(2015) Zhaolei Zhang et al.   BIOMATERIALS

Carbon quantum dots and their applications

(2015) Shi Ying Lim et al.   CHEMICAL SOCIETY REVIEWS

Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents

(2015) Josephine Modica-Napolitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

PK11195-chitosan-graft-polyethylenimine-modified SPION as a mitochondria-targeting gene carrier

(2015) You-Kyoung Kim et al.   JOURNAL OF DRUG TARGETING

Effect of the Conjugation Density of Triphenylphosphonium Cation on the Mitochondrial Targeting of Poly(amidoamine) Dendrimers

(2015) Elizabeth R. Bielski et al.   MOLECULAR PHARMACEUTICS

A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

(2015) Huan He et al.   Scientific Reports

Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity

(2015) Yan-feng Song et al.   Scientific Reports

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

Mitochondria-Targeted Cancer Therapy Using a Light-Up Probe with Aggregation-Induced-Emission Characteristics

(2014) Qinglian Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Peptide Conjugation Strategy for Improved Cellular Uptake and Mitochondria Targeting

(2014) Ran Lin et al.   BIOCONJUGATE CHEMISTRY

Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

(2014) Song Wu et al.   CHEMICAL COMMUNICATIONS

Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates

(2014) Xiaochen A. Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation

(2014) Špela Zupančič et al.   MOLECULAR PHARMACEUTICS

Mitochondrial Delivery of Doxorubicin via Triphenylphosphine Modification for Overcoming Drug Resistance in MDA-MB-435/DOX Cells

(2014) Min Han et al.   MOLECULAR PHARMACEUTICS

Nanoparticles as drug delivery systems

(2014) Agnieszka Z. Wilczewska et al.   Pharmacological Reports

Targeted Delivery of Doxorubicin to Mitochondria

(2013) Graham R. Chamberlain et al.   ACS Chemical Biology

Ex Vivo Programming of Dendritic Cells by Mitochondria-Targeted Nanoparticles to Produce Interferon-Gamma for Cancer Immunotherapy

(2013) Sean Marrache et al.   ACS Nano

Inorganic nanoparticles in drug delivery

(2013) Hedi Mattoussi et al.   ADVANCED DRUG DELIVERY REVIEWS

The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer

(2013) Jia Zhou et al.   BIOMATERIALS

Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

(2013) Simon P. Wisnovsky et al.   CHEMISTRY & BIOLOGY

Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism

(2013) Rida Mourtada et al.   PLoS One

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage

(2013) Wei-Hai Chen et al.   Scientific Reports

Nano-graphene in biomedicine: theranostic applications

(2012) Kai Yang et al.   CHEMICAL SOCIETY REVIEWS

Targeting drugs to mitochondria

(2012) Anne Heller et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting cancer cell mitochondria as a therapeutic approach

(2012) Shijun Wen et al.   Future Medicinal Chemistry

Role of monocarboxylate transporters in human cancers: state of the art

(2012) Céline Pinheiro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Synthesis of F16 conjugated with 5-fluorouracil and biophysical investigation of its interaction with bovine serum albumin by a spectroscopic and molecular modeling approach

(2012) Chen Xiang et al.   LUMINESCENCE

Classification of mitocans, anti-cancer drugs acting on mitochondria

(2012) Jiri Neuzil et al.   MITOCHONDRION

Mitochondrial-Targeting Nitrooxy-doxorubicin: A New Approach To Overcome Drug Resistance

(2012) Chiara Riganti et al.   MOLECULAR PHARMACEUTICS

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells

(2011) Xiao-Xing Wang et al.   BIOMATERIALS

Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma

(2011) Yang Yu et al.   BIOMATERIALS

Rerouting Chlorambucil to Mitochondria Combats Drug Deactivation and Resistance in Cancer Cells

(2011) Sonali B. Fonseca et al.   CHEMISTRY & BIOLOGY

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

(2011) Lan-Feng Dong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers

(2011) Yuri N. Antonenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Polymeric micelles as a new drug carrier system and their required considerations for clinical trials

(2010) Masayuki Yokoyama   Expert Opinion on Drug Delivery

Dequalinium induces apoptosis in peripheral blood mononuclear cells isolated from human chronic lymphocytic leukemia

(2010) Lucia Pajuelo et al.   INVESTIGATIONAL NEW DRUGS

New Insights of Transmembranal Mechanism and Subcellular Localization of Noncovalently Modified Single-Walled Carbon Nanotubes

(2010) Feifan Zhou et al.   NANO LETTERS

Advances in polymeric micelles for drug delivery and tumor targeting

(2010) Uttam Kedar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

(2010) Chris Oerlemans et al.   PHARMACEUTICAL RESEARCH

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

(2009) Y. N. Antonenko et al.   BIOCHEMISTRY-MOSCOW

Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet

(2009) Gerard GM D'Souza et al.   Expert Opinion on Drug Delivery

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria-targeting properties and photodynamic activities of porphyrin derivatives bearing cationic pendant

(2009) Wanhua Lei et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Cell-penetrating and cell-targeting peptides in drug delivery

(2008) Eric Vivès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mitochondria Targeting by Guanidine− and Biguanidine−Porphyrin Photosensitizers

(2008) Martha Sibrian-Vazquez et al.   BIOCONJUGATE CHEMISTRY

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

Prevention of free fatty acid-induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

(2008) Xudong Wu et al.   HEPATOLOGY