Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
Authors
Keywords
Terpenes, Triterpenes, Betulin, Betulinic acid, Cancer
Journal
PHYTOCHEMISTRY REVIEWS
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-25
DOI
10.1007/s11101-019-09623-1
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Betulin induces cytochrome c release and apoptosis in colon cancer cells via NOXA
- (2018) Zhiyuan Zhou et al. Oncology Letters
- Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy
- (2018) Hae Min So et al. ARCHIVES OF PHARMACAL RESEARCH
- Cell-Free Production of Pentacyclic Triterpenoid Compound Betulinic Acid from Betulin by the Engineered Saccharomyces cerevisiae
- (2017) Jianan Wu et al. MOLECULES
- Novel betulin derivative induces anti-proliferative activity by G2/M phase cell cycle arrest and apoptosis in Huh7 cells
- (2017) Zhen‑Jian Zhuo et al. Oncology Letters
- Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models
- (2017) An-Qi Zeng et al. Oncotarget
- Multiple molecular targets in breast cancer therapy by betulinic acid
- (2016) Runlan Luo et al. BIOMEDICINE & PHARMACOTHERAPY
- Betulinic acid inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition
- (2016) Chun-mei Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Improvement of betulinic acid biosynthesis in yeast employing multiple strategies
- (2016) Chen Zhou et al. BMC BIOTECHNOLOGY
- Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo
- (2016) Mirka Laavola et al. JOURNAL OF NATURAL PRODUCTS
- Betulinic acid and the pharmacological effects of tumor suppression
- (2016) Xia Zhang et al. Molecular Medicine Reports
- Effective Method of Purification of Betulin from Birch Bark: The Importance of Its Purity for Scientific and Medicinal Use
- (2016) Pavel Šiman et al. PLoS One
- Modulating betulinic acid production in Saccharomyces cerevisiae by managing the intracellular supplies of the co-factor NADPH and oxygen
- (2015) Jing Li et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)
- (2015) J.T. Banzouzi et al. JOURNAL OF ETHNOPHARMACOLOGY
- Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review
- (2015) Subha Rastogi et al. JOURNAL OF ETHNOPHARMACOLOGY
- Betulinic Acid and its Derivatives as Potential Antitumor Agents
- (2015) Dong-Mei Zhang et al. MEDICINAL RESEARCH REVIEWS
- Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus
- (2015) JeffersonRocha de A. Silva et al. Pharmacognosy Magazine
- Comprehensive Review on Betulin as a Potent Anticancer Agent
- (2015) Sylwia Katarzyna Król et al. Biomed Research International
- Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
- (2014) Dorina Gheorgheosu et al. Anti-Cancer Agents in Medicinal Chemistry
- Increase of betulinic acid production in Saccharomyces cerevisiae by balancing fatty acids and betulinic acid forming pathways
- (2014) Jing Li et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Betulinic Acid-Induced Cytotoxicity in Human Breast Tumor Cell Lines MCF-7 and T47D and its Modification by Tocopherol
- (2014) Reeta Tiwari et al. CANCER INVESTIGATION
- Betulinic acid and its derivatives: a patent review (2008 – 2013)
- (2014) René Csuk EXPERT OPINION ON THERAPEUTIC PATENTS
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis
- (2014) A R D Delbridge et al. ONCOGENE
- The role of triterpenes in the management of diabetes mellitus and its complications
- (2014) J. Nazaruk et al. PHYTOCHEMISTRY REVIEWS
- Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betulinic Acid Derivatives: Synergistic Effects with Miltefosine
- (2014) Maria C. Sousa et al. PLoS One
- Screening and Characterisation of Antimicrobial Properties of Semisynthetic Betulin Derivatives
- (2014) Shafiul Haque et al. PLoS One
- Extraction of betulin from birch bark and study of its physico-chemical and pharmacological properties
- (2014) S. A. Kuznetsova et al. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
- Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment
- (2014) Se Young Park et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response
- (2014) L Potze et al. Cell Death & Disease
- Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
- (2013) Stanisław Boryczka et al. MOLECULES
- JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells
- (2012) Zhiwei Zhao et al. BIOCHEMICAL JOURNAL
- Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
- (2012) Milan Urban et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
- (2012) L. Ouyang et al. CELL PROLIFERATION
- The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation
- (2012) Ying Wan et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation
- (2012) Cristina A Dehelean et al. Chemistry Central Journal
- Apoptosis and Human Diseases: Mitochondrion Damage and Lethal Role of Released Cytochrome c as Proapoptotic Protein
- (2012) P. Caroppi et al. CURRENT MEDICINAL CHEMISTRY
- Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models
- (2012) Codruta Şoica et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NF-κB as potential target in the treatment of melanoma
- (2012) Gabriele Madonna et al. Journal of Translational Medicine
- A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
- (2012) Y. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus
- (2012) Lili Huang et al. PLANTA
- Anti-inflammatory Effects of Scoparia dulcis L. and Betulinic Acid
- (2011) Jen-Chieh Tsai et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- The Biosynthesis of Isoprenoids and the Mechanisms Regulating It in Plants
- (2011) Kazunori OKADA BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis
- (2011) Y. Gao et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
- (2011) Irina N. Alimova et al. CELL CYCLE
- Synthesis and antibacterial activity of betulin esters
- (2011) K.-T. Chue et al. CHEMISTRY OF NATURAL COMPOUNDS
- Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects
- (2011) Jagan M.R. Patlolla et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release
- (2011) Qing Li et al. MOLECULAR CARCINOGENESIS
- Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt
- (2011) Hesham I. El-Askary et al. NATURAL PRODUCT RESEARCH
- Physico-chemical comparison of betulinic acid, betulin and birch bark extract andin vitroinvestigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines
- (2011) Codruta M. Şoica et al. NATURAL PRODUCT RESEARCH
- Birch bark extract as therapy for chronic hepatitis C – A pilot study
- (2011) Alexander N. Shikov et al. PHYTOMEDICINE
- The Cyt P450 Enzyme CYP716A47 Catalyzes the Formation of Protopanaxadiol from Dammarenediol-II During Ginsenoside Biosynthesis in Panax ginseng
- (2011) Jung-Yeon Han et al. PLANT AND CELL PHYSIOLOGY
- CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis
- (2011) Ery O. Fukushima et al. PLANT AND CELL PHYSIOLOGY
- Correction: Defining Natural History: Assessment of the Ability of College Students to Aid in Characterizing Clinical Progression of Niemann-Pick Disease, Type C
- (2011) Jenny Shin et al. PLoS One
- Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions
- (2011) Matthias Bache et al. Radiation Oncology
- Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
- (2011) Ana-Maria Florea et al. Cancers
- Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus
- (2010) Oxana B. Kazakova et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E2 production in human peripheral blood mononuclear cells
- (2010) Vijayan Viji et al. BRITISH JOURNAL OF PHARMACOLOGY
- Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
- (2010) Anupam Bishayee Frontiers in Bioscience-Landmark
- Antioxidant effects of betulin on porcine chondrocyte behavior in gelatin/C6S/C4S/HA modified tricopolymer scaffold
- (2010) Wen-Yang Lin et al. Materials Science & Engineering C-Materials for Biological Applications
- Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells
- (2010) Yang Li et al. MOLECULAR CARCINOGENESIS
- Mechanisms of Cisplatin Nephrotoxicity
- (2010) Ronald P. Miller et al. Toxins
- Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells
- (2009) Li-jing Yang et al. ACTA PHARMACOLOGICA SINICA
- Betulin Elicits Anti-Cancer Effects in Tumour Primary Cultures and Cell LinesIn Vitro
- (2009) Wojciech Rzeski et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells
- (2009) Malgorzata Drag-Zalesinska et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Betulinic and oleanolic acids isolated from Forsythia suspensa Vahl inhibit urease activity of Helicobacter pylori
- (2009) Seung-Jung Shin et al. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
- Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin
- (2009) KetLi Ho et al. Cancer Epidemiology
- Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells
- (2009) Pepita Gimenez-Bonafe et al. CURRENT CANCER DRUG TARGETS
- Targeting mitochondrial apoptosis by betulinic acid in human cancers
- (2009) Simone Fulda et al. DRUG DISCOVERY TODAY
- The effect of extraction process on polyphenol content, triterpene composition and bioactivity of yellow birch (Betula alleghaniensis Britton) extracts
- (2009) Papa Niokhor Diouf et al. INDUSTRIAL CROPS AND PRODUCTS
- Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells
- (2009) Manoj K. Pandey et al. INTERNATIONAL JOURNAL OF CANCER
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Rational Design and Semisynthesis of Betulinic Acid Analogues as Potent Topoisomerase Inhibitors
- (2009) Fatma M. Abdel Bar et al. JOURNAL OF NATURAL PRODUCTS
- Recent developments in anti-inflammatory natural products
- (2009) Raju Gautam et al. MEDICINAL RESEARCH REVIEWS
- NF-κB and cancer: how intimate is this relationship
- (2009) Sahdeo Prasad et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines
- (2009) Marcin Drag et al. MOLECULES
- Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts
- (2009) Sebastian Jäger et al. MOLECULES
- Cytoplasmic functions of the tumour suppressor p53
- (2009) Douglas R. Green et al. NATURE
- Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice
- (2009) Matheus Santos de Sá et al. PARASITOLOGY RESEARCH
- Antiallergenic activity of birch bark dry extract with at least 70% betulin content
- (2009) L. P. Kovalenko et al. PHARMACEUTICAL CHEMISTRY JOURNAL
- Antiprotozoal activity of Betulinic acid derivatives
- (2009) D.B. Domínguez-Carmona et al. PHYTOMEDICINE
- Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy
- (2009) Melanie Laszczyk PLANTA MEDICA
- Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol
- (2009) Franziska B. Mullauer et al. PLoS One
- Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid
- (2009) Andros Theo et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives
- (2008) Vivek Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Terpenoids and breast cancer chemoprevention
- (2008) Thangaiyan Rabi et al. BREAST CANCER RESEARCH AND TREATMENT
- Betulinic Acid for Cancer Treatment and Prevention
- (2008) Simone Fulda INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities
- (2008) Jessica Plati et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes
- (2008) Stéphane Fontanay et al. JOURNAL OF ETHNOPHARMACOLOGY
- Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins
- (2008) Charles Gauthier et al. JOURNAL OF NATURAL PRODUCTS
- Betulinic acid suppresses constitutive and TNFα-induced NF-κB activation and induces apoptosis in human prostate carcinoma PC-3 cells
- (2008) Thangaiyan Rabi et al. MOLECULAR CARCINOGENESIS
- Betulinic acid: A natural product with anticancer activity
- (2008) Simone Fulda MOLECULAR NUTRITION & FOOD RESEARCH
- A Preliminary Pharmacokinetic Study of Betulin, the Main Pentacyclic Triterpene from Extract of Outer Bark of Birch (Betulae alba cortex)
- (2008) Sebastian Jäger et al. MOLECULES
- Betulin binds to γ-aminobutyric acid receptors and exerts anticonvulsant action in mice
- (2008) R MUCENIECE et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now