A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Small-molecule allosteric inhibitors of BAX

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Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

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Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation

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Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

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Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

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A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

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CIS is a potent checkpoint in NK cell–mediated tumor immunity

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

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Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

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Protein–protein interactions as drug targets

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Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis

(2015) Shamim Naghdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

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Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

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Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule–specific knockout mouse models

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BH3 profiling in whole cells by fluorimeter or FACS

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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BID-induced structural changes in BAK promote apoptosis

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Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

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Mass Spectrometry-Based Proteomics in Preclinical Drug Discovery

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XDS

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Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

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Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

(2010) Nichole A. Reyes et al.   JOURNAL OF CLINICAL INVESTIGATION

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

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Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

(2009) S. Someya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

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Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

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