Review
Biochemistry & Molecular Biology
Marija Petkovic, Michelle Vang Mouritzen, Biljana Mojsoska, Havard Jenssen
Summary: Cutaneous wound healing is a crucial biological process, with chronic wounds often arising from persistent inflammatory conditions caused by factors such as autoimmune diseases. Host defense peptides play a significant role in modulating immune skin function and offer potential for inspiring topical treatments for chronic wounds.
Article
Food Science & Technology
Xin Ma, Fan Yang, Xuanyi Meng, Yong Wu, Ping Tong, Jinyan Gao, Hongbing Chen, Xin Li
Summary: This study identified 109 BLG-derived peptides from simulated digestion of cow's milk, which showed good transport absorption capacity in Caco-2 cells. Some peptides were found to promote activation of DC and T cells.
Review
Biochemistry & Molecular Biology
Matthew Drayton, Julia P. Deisinger, Kevin C. Ludwig, Nigare Raheem, Anna Mueller, Tanja Schneider, Suzana K. Straus
Summary: The rapid rise of multidrug-resistant bacteria has raised concerns about the effectiveness of traditional antibiotics. Antimicrobial peptides, with their diverse mechanisms of actions, offer a promising solution to combat these pathogens. This review discusses the mechanisms of antibiotic resistance and the potential of antimicrobial peptides in providing a more robust treatment of bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yuxing Wang, Zhuangzhuang Liang, Fang Shen, Wenting Zhou, Tabusi Manaer, Didaier Jiaerken, Xinhua Nabi
Summary: This study aimed to extract and identify bioactive peptides from fermented camel milk in Xinjiang and investigate their immunomodulatory effects and mechanisms using network pharmacology and molecular docking. The results showed that the bioactive peptides from fermented camel milk were associated with anti-inflammatory and immune regulation. This study provides a scientific basis for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tuong Ngoc-Gia Nguyen, Cuong Viet Pham, Rocky Chowdhury, Shweta Patel, Satendra Kumar Jaysawal, Yingchun Hou, Huo Xu, Lee Jia, Andrew Duan, Phuong Ha-Lien Tran, Wei Duan
Summary: In the past decade, there has been an expansion in the development of plant-derived extracellular nanovesicles (EVs) for precision therapy. However, the lack of effective methods for isolation and characterization of plant EVs hampers progress. In this study, a 3D inner filter-based method was developed to extract apoplastic fluid (AF) from blueberry, enabling EV isolation and downstream applications. Blueberry-derived EVs (BENVs) were found to have high drug loading capacity and the ability to modulate cytokine release, making them a promising nano-bio platform for immunomodulatory therapies.
Article
Food Science & Technology
Mengwei Chen, Fan Zhang, Yujie Su, Cuihua Chang, Junhua Li, Luping Gu, Yanjun Yang
Summary: This study found that preheat treatment could promote egg white hydrolysis, resulting in higher peptide yield. Supplementation with peptides had a significant positive effect on the immune organ index and alleviated spleen tissue damage in immunosuppressed mice. The immunomodulatory effects of peptides might be related to the presence of abundant branched-chain amino acids.
Article
Chemistry, Medicinal
Nauman Nazeer, Juan Carlos Rodriguez-Lecompte, Marya Ahmed
Summary: This study focuses on the design and development of disulfide bridge-linked antimicrobial peptides using Angiogenin 4 (chAng4) as a template. The results demonstrate that the synthetic mCA4 peptides show superior antibacterial efficacies, are non-toxic and non-hemolytic, and can mediate bacterial flocculation and killing without external stimuli.
Article
Biotechnology & Applied Microbiology
Eliana Dell'Olmo, Rosa Gaglione, Angela Cesaro, Valeria Cafaro, Wieke R. Teertstra, Hans de Cock, Eugenio Notomista, Henk P. Haagsman, Edwin J. A. Veldhuizen, Angela Arciello
Summary: Therapeutic options for invasive fungal infections are limited, highlighting the need for novel antifungal agents. ApoB-derived peptides show promising antifungal properties, interacting with fungal cells and causing membrane damage, making them potential candidates for effective antifungal agents.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Infectious Diseases
Waqas Ali, Ahmad Elsahn, Darren S. J. Ting, Harminder S. Dua, Imran Mohammed
Summary: One of the major challenges in the medical community today is the increasing antimicrobial resistance (AMR) coupled with the reduction in available antimicrobial treatments. The overuse of antibiotics has led to a significant rise in AMR, with estimates suggesting over 10 million lives could be lost by 2050. Host Defence Peptides (HDPs) have shown promise as an alternative to traditional antibiotics, demonstrating efficacy against currently resistant microbial variants. In light of the global COVID-19 pandemic, the potential use of HDPs as a therapeutic option and preventive measure against the spread of the SARS-CoV-2 variant has been examined.
Article
Biochemistry & Molecular Biology
Yunlong Jiang, Yuan Qi, Xiaoting Liu, Li Fang, Yawen Gao, Chunlei Liu, Dan Wu, Xiyan Wang, Fanrui Zhao, Ji Wang, Weihong Min
Summary: LYLKPR derived from fermented yak milk demonstrated neuroprotective effects by ameliorating oxidative stress-mediated neuronal injury and inhibiting the activation of the NLRP3 inflammasome.
Review
Microbiology
Robert E. W. Hancock, Morgan A. Alford, Evan F. Haney
Summary: This review discusses how the complex functional attributes of host defence peptides offer opportunities for antimicrobial therapeutics, with a focus on their emerging antibiofilm properties. The mechanisms of action of antibiofilm peptides are compared with antimicrobial peptides. Additionally, obstacles to translating candidate peptides into therapeutics and potential solutions are discussed.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
John Kerr White, Taj Muhammad, Emelie Alsheim, Soumitra Mohanty, Anna Blasi-Romero, Sunithi Gunasekera, Adam A. Stromstedt, Natalia Ferraz, Ulf Goransson, Annelie Brauner
Summary: The synthetic peptide CD4-PP, designed by dimerization and backbone cyclization of the antimicrobial region of human cathelicidin, LL-37, shows potential as an alternative therapy for uropathogenic bacteria. It is active against common uropathogens at low concentrations and can prevent biofilm formation, dissolve mature biofilms, and induce production of antimicrobial peptide and tight junction proteins by uroepithelial cells. It also reduces uropathogen survival during cell infection. Coating urinary catheter pieces with CD4-PP can reduce the attachment of E. coli.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Sepide Behrouz, Saeideh Saadat, Arghavan Memarzia, Hadi Sarir, Gert Folkerts, Mohammad Hossein Boskabady
Summary: Camel milk has various health benefits and has the potential to treat diseases caused by inflammation, oxidative stress, and immune dysregulation. Its bioactive components, including lactoferrin, alpha-lactalbumin, beta-caseins, and vitamin C, contribute to its therapeutic properties.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eliana Dell'Olmo, Rosa Gaglione, Angela Arciello, Renata Piccoli, Valeria Cafaro, Antimo Di Maro, Sara Ragucci, Raffaele Porta, C. Valeria L. Giosafatto
Summary: The study demonstrated that r(P)ApoB(L) can be enzymatically modified by mTG, specifically with highly selective crosslinking at Lys-18. However, the antimicrobial activity of the peptide was found to be lost when grafted into protein films after mTG-catalyzed crosslinking.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Pharmacology & Pharmacy
Lei Wu, Lingling Wang, Xi Liu, Yuli Bai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, Yongxiang Zheng, Tao Gong, Zhirong Zhang, Yuan Huang
Summary: Exosomes, as endogenous courier vesicles, have gained increasing attention as biomimetic drug delivery vehicles. In this study, insulin-loaded milk-derived exosomes were fabricated and demonstrated to exhibit superior hypoglycemic effects when orally administered, compared with subcutaneously injected insulin. Mechanism studies revealed the multi-functional properties of milk-derived exosomes, including active multi-targeting uptake, pH adaptation, signal pathway activation, and mucus penetration, which contribute to their excellent oral performance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Hong-ming Du, Li-ya Wang, Xiao-hui Zheng, Wei Tang, Lei Liu, Wei Jing, Yun-feng Lin, Wei-dong Tian, Jie Long
JOURNAL OF HARD TISSUE BIOLOGY
(2015)
Article
Anatomy & Morphology
Hong-ming Du, Xiao-hui Zheng, Li-ya Wang, Wei Tang, Lei Liu, Wei Jing, Yun-feng Lin, Wei-dong Tian, Jie Long
CELLS TISSUES ORGANS
(2012)
Article
Medicine, Research & Experimental
Li-ya Wang, Hong-ming Du, Gang Zhang, Wei Tang, Lei Liu, Wei Jing, Jie Long
MEDICAL HYPOTHESES
(2011)
Article
Dentistry, Oral Surgery & Medicine
Jie Long, Peng Li, Hong-ming Du, Lei Liu, Xiao-hui Zheng, Yun-feng Lin, Hang Wang, Wei Jing, Wei Tang, Wei-hui Chen, Wei-dong Tian
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
(2011)
Review
Oncology
Jia Li, Hongming Du, Peng Li, Jingkui Zhang, Weidong Tian, Wei Tang
Article
Oncology
Ya-Dong Luo, Xu Ding, Hong-Ming Du, Yu-Nong Wu, Huai-Qi Li, He-Ming Wu, Xiao-Min Zhang
MOLECULAR MEDICINE REPORTS
(2019)
Article
Cell & Tissue Engineering
Yadong Luo, Ran Ge, Heming Wu, Xu Ding, Haiyang Song, Huan Ji, Meng Li, Yunan Ma, Sheng Li, Chenxing Wang, Hongming Du
STEM CELL RESEARCH & THERAPY
(2019)
Article
Medicine, Research & Experimental
Chenxing Wang, Heming Wu, Xu Ding, Huan Ji, Pengfei Jiao, Haiyang Song, Sheng Li, Hongming Du
MEDICAL HYPOTHESES
(2020)
Article
Cell & Tissue Engineering
Yadong Luo, Xu Ding, Huan Ji, Meng Li, Haiyang Song, Sheng Li, Chenxing Wang, Heming Wu, Hongming Du
STEM CELL RESEARCH & THERAPY
(2020)
Article
Anatomy & Morphology
Fucun Zhu, Yi Zhong, Huan Ji, Ran Ge, Lu Guo, Haiyang Song, Heming Wu, Pengfei Jiao, Sheng Li, Chenxing Wang, Hongming Du
Summary: The study has found that ACE2 and TMPRSS2 are mainly expressed in the cytomembrane and cytoplasm of serous acinus cells in parotid and submandibular glands, while the spike protein of SARS-CoV-2 can bind to ACE2 in salivary glands in vitro. Additionally, exogenous ACE2 and TMPRSS2 can anchor and fuse to oral mucosa in vitro. Therefore, the expression of ACE2 and TMPRSS2 in human saliva may play a significant role in SARS-CoV-2 infection.
JOURNAL OF ANATOMY
(2022)
Article
Cell & Tissue Engineering
Meng Li, Xiaomin Zhang, Xu Ding, Yang Zheng, Hongming Du, Huaiqi Li, Huan Ji, Zeyu Wang, Pengfei Jiao, Xiaomeng Song, Yi Zhong, HeMing Wu
CELL TRANSPLANTATION
(2020)
Article
Cell & Tissue Engineering
Yadong Luo, Huan Ji, Yan Cao, Xu Ding, Meng Li, Haiyang Song, Sheng Li, Chenxing WaTableng, Heming Wu, Jian Meng, Hongming Du
CELL TRANSPLANTATION
(2020)
Article
Cell & Tissue Engineering
Huan Ji, Xu Ding, Wei Zhang, Yang Zheng, Hongming Du, Yangyu Zheng, Haiyang Song, Meng Li, Yue Jiang, Jiaxiang Xie, Ming Wu, Pengfei Jiao, Zeyu Wang, Heming Wu, Yi Zhong
CELL TRANSPLANTATION
(2020)
