Expression and Function of Host Defense Peptides at Inflammation Sites

Reassessing the Host Defense Peptide Landscape

(2019) Evan F. Haney et al.   Frontiers in Chemistry

Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease

(2019) Pelin Uysal et al.   International Journal of Chronic Obstructive Pulmonary Disease

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis

(2019) QiXing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor

(2019) Carrie Q. Sun et al.   CANCER BIOLOGY & THERAPY

Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study

(2019) Sushma Kalmodia et al.   Scientific Reports

Promoter DNA methylation contributes to human β-defensin-1 deficiency in atopic dermatitis

(2018) Yoo-Hun Noh et al.   Animal Cells and Systems

Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility

(2018) E. Cerrillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics

(2018) Sarah Line Skovbakke et al.   CURRENT PHARMACEUTICAL DESIGN

Host-defense peptides and their potential use as biomarkers in human diseases

(2018) Osmar N. Silva et al.   DRUG DISCOVERY TODAY

Antimicrobial peptide gene expression in periodontitis patients: A pilot study

(2018) Marie-Laure Jourdain et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells

(2018) Verena Kopfnagel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitis

(2018) L. C. M. Costa et al.   JOURNAL OF PERIODONTAL RESEARCH

Modulation of toll-like receptor signaling by antimicrobial peptides

(2018) Ernest Y. Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Multifaceted immune functions of human defensins and underlying mechanisms

(2018) Saahil Fruitwala et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors

(2018) Toshiya Takahashi et al.   Scientific Reports

Transcriptional regulation of human defense peptides: a new direction in infection control

(2018) Santi M. Mandal et al.   BIOLOGICAL CHEMISTRY

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells

(2018) Clément Bonamy et al.   Scientific Reports

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

(2017) Frank Kolbinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLN-58, an Additional hCAP18 Processing Form, Found in the Lesion Vesicle of Palmoplantar Pustulosis in the Skin

(2017) Masamoto Murakami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Critical Review on the Use of Support Values in Tree Viewers and Bioinformatics Toolkits

(2017) Lucas Czech et al.   MOLECULAR BIOLOGY AND EVOLUTION

Human β-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages

(2017) Di Cui et al.   MOLECULAR IMMUNOLOGY

β-Defensins in the Fight against Helicobacter pylori

(2017) Raffaela Pero et al.   MOLECULES

Evaluation of nasal fluid β-defensin 2 levels in children with allergic rhinitis

(2017) Fatih Dilek et al.   TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

(2017) Yue-Ming Ling et al.   Scientific Reports

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

(2017) Sonia Carta et al.   Frontiers in Immunology

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

Fecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative Colitis

(2016) Shuji Kanmura et al.   DIGESTION

LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages

(2016) Alexander Stephan et al.   IMMUNOLOGY

Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization

(2016) Nathan K. Archer et al.   INFECTION AND IMMUNITY

The Roles of Cathelicidin LL-37 in Inflammatory Bowel Disease

(2016) Lihua Sun et al.   INFLAMMATORY BOWEL DISEASES

Non-coding Double-stranded RNA and Antimicrobial Peptide LL-37 Induce Growth Factor Expression from Keratinocytes and Endothelial Cells

(2016) Christopher A. Adase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pep-Calc.com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment

(2016) Sam Lear et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori

(2016) Beverly R. E. A. Dixon et al.   PLoS One

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation

(2016) Matthew Brook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral antimicrobial peptides: Types and role in the oral cavity

(2016) Zohaib Khurshid et al.   SAUDI PHARMACEUTICAL JOURNAL

Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling

(2016) Dan Xu et al.   Oncotarget

Novel epidermal growth factor receptor pathway mediates release of human β-defensin 3 fromHelicobacter pylori-infected gastric epithelial cells

(2016) Jibran S. Muhammad et al.   Pathogens and Disease

Impact of DEFB1 gene regulatory polymorphisms on hBD-1 salivary concentration

(2015) Vania Polesello et al.   ARCHIVES OF ORAL BIOLOGY

Review paper Cathelicidin impact on inflammatory cells

(2015) Justyna Agier et al.   Central European Journal of Immunology

Defensins: “Simple” antimicrobial peptides or broad-spectrum molecules?

(2015) Meggy Suarez-Carmona et al.   CYTOKINE & GROWTH FACTOR REVIEWS

LL-37 Immunomodulatory Activity during Mycobacterium tuberculosis Infection in Macrophages

(2015) Flor Torres-Juarez et al.   INFECTION AND IMMUNITY

Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes

(2015) Rithee Smithrithee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Sequential Immune Responses: The Weapons of Immunity

(2015) Charles D. Mills et al.   Journal of Innate Immunity

Airwayβ-Defensin-1 Protein Is Elevated in COPD and Severe Asthma

(2015) Katherine J. Baines et al.   MEDIATORS OF INFLAMMATION

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Salivary Antimicrobial Peptides in Early Detection of Periodontitis

(2015) Güliz N. Güncü et al.   Frontiers in Cellular and Infection Microbiology

Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases

(2015) Hong-Zhi Sun   MEDICAL SCIENCE MONITOR

Do Antimicrobial Peptides and Complement Collaborate in the Intestinal Mucosa?

(2015) Zoë A. Kopp et al.   Frontiers in Immunology

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

(2015) Akhirunnesa Mily et al.   PLoS One

Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis

(2015) Ni Shi et al.   Oncotarget

Effect of growth factors on antimicrobial peptides and pro-inflammatory mediators during wound healing

(2014) H. Dommisch et al.   Clinical Oral Investigations

Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA

(2014) Roberto Lande et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-22 Up-Regulates β-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-κB Signaling Pathway

(2014) Amin Li et al.   INFLAMMATION

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathelicidin Antimicrobial Peptides Inhibit Hyaluronan-Induced Cytokine Release and Modulate Chronic Allergic Dermatitis

(2014) Y. Morioka et al.   JOURNAL OF IMMUNOLOGY

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

(2014) Ariane Neumann et al.   Journal of Innate Immunity

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

(2014) Mahmoud H. Abou Alaiwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defensins and Sepsis

(2014) Guo-Hao Xie et al.   Biomed Research International

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries

(2014) Krzysztof Bielawski   MEDICAL SCIENCE MONITOR

LEAP-2, LL-37 and RNase7 in tonsillar tissue: downregulated expression in seasonal allergic rhinitis

(2014) Jesper Bogefors et al.   Pathogens and Disease

Pattern recognition receptors in innate immunity, host defense, and immunopathology

(2013) Rahul Suresh et al.   ADVANCES IN PHYSIOLOGY EDUCATION

TLR-Mediated Airway IL-17C Enhances Epithelial Host Defense in an Autocrine/Paracrine Manner

(2013) Hideki Kusagaya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Peptide design for antimicrobial and immunomodulatory applications

(2013) Evan F. Haney et al.   BIOPOLYMERS

Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer

(2013) Shuhei Abe et al.   JOURNAL OF HUMAN GENETICS

 -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-  Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

(2013) P. Tewary et al.   JOURNAL OF IMMUNOLOGY

Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract

(2013) John David Spencer et al.   KIDNEY INTERNATIONAL

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

DAMPs activating innate and adaptive immune responses in COPD

(2013) S D Pouwels et al.   Mucosal Immunology

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Alarmins, inflammasomes and immunity

(2013) DavidM Ojcius et al.   Biomedical Journal

Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis

(2012) Yvonne Dombrowski et al.   EXPERIMENTAL DERMATOLOGY

ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?

(2012) Fiona Semple et al.   Journal of Innate Immunity

Influence of Periodontal Status and Periodontopathogens on Levels of Oral Human β-Defensin-2 in Saliva

(2012) Alexandre L. Pereira et al.   JOURNAL OF PERIODONTOLOGY

Cathelicidins: family of antimicrobial peptides. A review

(2012) Ewa M. Kościuczuk et al.   MOLECULAR BIOLOGY REPORTS

Enhanced expression of human β-defensin 2 in peripheral lungs of patients with chronic obstructive pulmonary disease

(2012) Zenglin Liao et al.   PEPTIDES

Enteric alpha defensins in norm and pathology

(2012) Nikolai A Lisitsyn et al.   Annals of Clinical Microbiology and Antimicrobials

The Yin and Yang of Human Beta-Defensins in Health and Disease

(2012) Aaron Weinberg et al.   Frontiers in Immunology

Intestinal antimicrobial peptides during homeostasis, infection, and disease

(2012) Luciana R. Muniz et al.   Frontiers in Immunology

Understanding the roles of gingival beta-defensins

(2012) Ulvi Kahraman Gursoy et al.   Journal of Oral Microbiology

Human Beta-Defensin-1, -2, and -3 Exhibit Opposite Effects on Oral Squamous Cell Carcinoma Cell Proliferation

(2011) Jochen Winter et al.   CANCER INVESTIGATION

Antimicrobial peptides: key components of the innate immune system

(2011) Mukesh Pasupuleti et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rosacea as a Disease of Cathelicidins and Skin Innate Immunity

(2011) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Mechanisms controlling Th17 cytokine expression and host defense

(2011) Jeremy P. McAleer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract

(2011) John D. Spencer et al.   KIDNEY INTERNATIONAL

Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease

(2011) Ellen Andresen et al.   PLoS One

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

(2010) Robert Bucki et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

CCR6 Regulation of the Actin Cytoskeleton Orchestrates Human Beta Defensin-2- and CCL20-mediated Restitution of Colonic Epithelial Cells

(2009) Rebecca A. Vongsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

Loss of human β-defensin 1, 2, and 3 expression in oral squamous cell carcinoma

(2009) S. Joly et al.   Oral microbiology and immunology

Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1

(2009) Nitya Venkataraman et al.   PLOS BIOLOGY

High α-defensin levels in patients with systemic lupus erythematosus

(2008) Zev M. Sthoeger et al.   IMMUNOLOGY

Antimicrobial peptides and the skin immune defense system

(2008) Jürgen Schauber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE