Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hippo/Mst1 Stimulates Transcription of the Proapoptotic Mediator NOXA in a FoxO1-Dependent Manner

(2011) K. Valis et al.   CANCER RESEARCH

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

(2011) Lan-Feng Dong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

(2011) Won-Seok Choi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

Somatic mutations of mitochondrial DNA in aging and cancer progression

(2010) Hsin-Chen Lee et al.   AGEING RESEARCH REVIEWS

α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

(2010) Lubomir Prochazka et al.   APOPTOSIS

Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D

(2010) Caroline Ballot et al.   APOPTOSIS

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage

(2010) Xuesong Liu et al.   CANCER BIOLOGY & THERAPY

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism

(2010) Julia Strathmann et al.   FASEB JOURNAL

Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin

(2010) Kristin K. Brown et al.   FEBS LETTERS

Involvement of Ca2+ and ROS in α-tocopheryl succinate-induced mitochondrial permeabilization

(2010) Vladimir Gogvadze et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

(2010) Lan-Feng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate

(2010) Renaud Warin et al.   MOLECULAR CARCINOGENESIS

The architecture of respiratory complex I

(2010) Rouslan G. Efremov et al.   NATURE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Downregulation of Epidermal Growth Factor Receptor Expression Contributes toα-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

(2010) Ming-Chieh Shun et al.   Journal of Oncology

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Prevention of Mammary Carcinogenesis in MMTV-neu Mice by Cruciferous Vegetable Constituent Benzyl Isothiocyanate

(2009) R. Warin et al.   CANCER RESEARCH

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery

(2009) B Zhivotovsky et al.   CELL DEATH AND DIFFERENTIATION

Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway

(2009) G Liot et al.   CELL DEATH AND DIFFERENTIATION

Suppression of Tumor Growth In vivo by the Mitocan  -tocopheryl Succinate Requires Respiratory Complex II

(2009) L.-F. Dong et al.   CLINICAL CANCER RESEARCH

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria-targeting properties and photodynamic activities of porphyrin derivatives bearing cationic pendant

(2009) Wanhua Lei et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

(2009) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D

(2009) C. Ballot et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondria as targets for cancer therapy

(2009) Stephen J. Ralph et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Torque generation and elastic power transmission in the rotary FOF1-ATPase

(2009) Wolfgang Junge et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Mysterious Metformin

(2009) C. R. Chong et al.   ONCOLOGIST

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species

(2008) Romana Fato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria Targeting by Guanidine− and Biguanidine−Porphyrin Photosensitizers

(2008) Martha Sibrian-Vazquez et al.   BIOCONJUGATE CHEMISTRY

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD

Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3'-Diindolylmethane in Healthy Subjects

(2008) G. A. Reed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

(2008) Stephen Safe et al.   CANCER LETTERS

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

DNA polymerase γ inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells

(2008) Ryohei Sasaki et al.   CANCER SCIENCE

A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols

(2008) Andrea Mattarei et al.   CHEMBIOCHEM

Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax☆

(2008) N BLATT et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Benzyl Isothiocyanate Targets Mitochondrial Respiratory Chain to Trigger Reactive Oxygen Species-dependent Apoptosis in Human Breast Cancer Cells

(2008) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Mitochondrial Superoxide Production by the Cytochromebc1Complex

(2008) Stefan Dröse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts

(2008) Rosário Monteiro et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Expanding Circle of Inhibition: Small-Molecule Inhibitors of Bcl-2 as Anticancer Cell and Antiangiogenic Agents

(2008) Benjamin D. Zeitlin et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel HPMA Copolymer-Bound Constructs for Combined Tumor and Mitochondrial Targeting

(2008) Vaikunth Cuchelkar et al.   MOLECULAR PHARMACEUTICS

Cancer complexity slows quest for cure

(2008) Erika Check Hayden   NATURE

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Generation of Reactive Oxygen Species by Mitochondrial Complex I: Implications in Neurodegeneration

(2008) Romana Fato et al.   NEUROCHEMICAL RESEARCH

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

(2008) L-F Dong et al.   ONCOGENE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY

Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation

(2008) Mariola Pęczkowska et al.   Nature clinical practice. Endocrinology & metabolism

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY