Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

PLCB3 Loss-of-function Reduces P. aeruginosa-dependent IL-8 Release in Cystic Fibrosis

(2018) Alessandro Rimessi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Inflammation in cystic fibrosis: An update

(2018) Erica A. Roesch et al.   PEDIATRIC PULMONOLOGY

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy limits activation of the inflammasomes

(2017) Michihiro Takahama et al.   IMMUNOLOGICAL REVIEWS

The mitochondrial unfolded protein response: Signaling from the powerhouse

(2017) Mohammed A. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

(2017) Daniela M. Arduino et al.   MOLECULAR CELL

Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis

(2016) Paola Prandini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

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The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies

(2016) Alessandro Rimessi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cystic fibrosis

(2016) J Stuart Elborn   LANCET

The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux

(2016) Zhou Long et al.   Oncotarget

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitophagy confers resistance to siderophore-mediated killing byPseudomonas aeruginosa

(2015) Natalia V. Kirienko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis

(2015) Alessandro Rimessi et al.   Nature Communications

KB-R7943, a plasma membrane Na+/Ca2+ exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore

(2014) Brian M. Wiczer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast

(2014) Stefan Böckler et al.   DEVELOPMENTAL CELL

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1

(2014) Rosa Rubino et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

(2014) Marcella Facchini et al.   Jove-Journal of Visualized Experiments

Regulation Where Autophagy Intersects the Inflammasome

(2013) Mary A. Rodgers et al.   ANTIOXIDANTS & REDOX SIGNALING

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

(2013) Alessandro Rimessi et al.   Autophagy

Cystic Fibrosis Therapeutics

(2013) Lucas R. Hoffman et al.   CHEST

NCX3 regulates mitochondrial Ca 2+ handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death

(2013) Antonella Scorziello et al.   JOURNAL OF CELL SCIENCE

Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?

(2013) Carey A. Hobbs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection

(2013) Robert D. Junkins et al.   PLoS One

The Cystic Fibrosis Gene: A Molecular Genetic Perspective

(2013) L.-C. Tsui et al.   Cold Spring Harbor Perspectives in Medicine

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

ATP synthesis and storage

(2012) Massimo Bonora et al.   Purinergic Signalling

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

(2011) Z. Sheng et al.   BLOOD

A dual role for Ca2+ in autophagy regulation

(2011) Jean-Paul Decuypere et al.   CELL CALCIUM

Dietary Antioxidants: Immunity and Host Defense

(2011) Maria A. Puertollano et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phospholipase C- 3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells

(2011) V. Bezzerri et al.   JOURNAL OF IMMUNOLOGY

KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

(2010) Tatiana Brustovetsky et al.   BRITISH JOURNAL OF PHARMACOLOGY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Distinct Pathogenesis and Host Responses during Infection of C. elegans by P. aeruginosa and S. aureus

(2010) Javier E. Irazoqui et al.   PLoS Pathogens

Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca2+Store Expansion Is Mediated by X-box Binding Protein-1

(2009) Mary E. B. Martino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Effect of KB-R7943 Against Glutamate Excitotoxicity is Related to Mild Mitochondrial Depolarization

(2009) T. P. Storozhevykh et al.   NEUROCHEMICAL RESEARCH

The versatility of mitochondrial calcium signals: From stimulation of cell metabolism to induction of cell death

(2008) Alessandro Rimessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Characterization of SLC26A9, Facilitation of Cl- Transport by Bicarbonate

(2008) Celine Loriol et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY