Article
Cell Biology
Catherine A. Bellissimo, Luca J. Delfinis, Meghan C. Hughes, Patrick C. Turnbull, Shivam Gandhi, Sara N. DiBenedetto, Fasih A. Rahman, Peyman Tadi, Christina A. Amaral, Ali Dehghani, James N. Cobley, Joe Quadrilatero, Uwe Schlattner, Christopher G. R. Perry
Summary: This study aimed to determine whether the prospective mitochondrial-enhancing compound Olesoxime can prevent early-stage mitochondrial stress in limb and respiratory muscle from D2.mdx mice. Results showed that Olesoxime selectively preserved or maintained muscle sensitivity to creatine, reduced creatine kinase release, and improved some indices of muscle quality.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Przygoda, Dorota Bartusik-Aebisher, Klaudia Dynarowicz, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, David Aebisher
Summary: This review explores the application of photodynamic therapy (PDT) in cancer treatment, emphasizing its precise targeting and protection of healthy tissue. The key role of singlet oxygen in initiating apoptosis and other cell death pathways is highlighted, along with the complex interactions of cellular components. The review concludes by emphasizing the opportunities and potential for optimizing PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Artyom Y. Baev, Andrey Y. Vinokurov, Irina N. Novikova, Viktor V. Dremin, Elena V. Potapova, Andrey Y. Abramov
Summary: Neurodegenerative disorders are devastating diseases characterized by the loss of neurons in specific brain regions. Recent research has identified genes, toxins, and risk factors associated with these diseases, and has found similarities in the involvement of mitochondria, oxidative stress, and abnormal calcium signaling in neurons and astrocytes.
Article
Biochemistry & Molecular Biology
Weiyu Feng, Jinbang Wang, Baodong Li, Yonggang Liu, Dongli Xu, Ke Cheng, Jing Zhuang
Summary: This study conducted an in-depth investigation on the toxicological effects of graphene oxide (GO) on intestinal tissues, and clarified its toxic effects and molecular mechanisms on inducing intestinal cell death. The study found that GO can cause an imbalance in mitochondrial homeostasis and cell apoptosis, leading to damage in the small intestine. These findings provide important safety references for the biomedical applications of GO.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Cell Biology
Sarah K. Skinner, Angelo Solania, Dennis W. Wolan, Michael S. Cohen, Terence E. Ryan, Russell T. Hepple
Summary: The study found that mitochondrial permeability transition (MPT) is a novel mechanism of skeletal muscle atrophy, operating through the release of mROS and activation of caspase-3. The experiment demonstrated that inhibiting MPT, mROS, or caspase-3 could prevent muscle atrophy in both chemical-induced and disuse models.
Review
Pharmacology & Pharmacy
Shaoyun Zhou, Qinwei Yu, Luyong Zhang, Zhenzhou Jiang
Summary: Mitochondria play multiple roles in cellular processes, acting as energy producers and biosynthetic centers. The opening of the mitochondrial permeability transition pore (mPTP) is a major contributor to mitochondrial dysfunction, leading to cellular damage or death. Cyclophilin D (CypD), a mitochondrial chaperone, has been identified as a key mediator of mPTP. Inhibiting CypD activity has shown to protect against diseases such as ischemia/reperfusion injury and neurodegenerative disorders.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Jason R. Treberg
Summary: Mitochondria play a central role in cellular reactive oxygen species, serving both as a potential source and due to their substantial antioxidant capacity. Studies focus on developing mitochondria as intrinsic regulators of H2O2 present challenges in integrating both consumption and production mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniil A. A. Chernyavskij, Olga Yu. Pletjushkina, Anastasia V. V. Kashtanova, Ivan I. I. Galkin, Anna Karpukhina, Boris V. V. Chernyak, Yegor S. S. Vassetzky, Ekaterina N. N. Popova
Summary: Many muscular pathologies involving oxidative stress and elevated TNF levels cause muscle protein catabolism and impair myogenesis. This study found that mitoROS play a role in this process by triggering and enhancing mitophagy during myogenesis. Treatment with TNF before myogenesis decreases myoblast fusion and MYH2 synthesis, but antioxidants and autophagy suppression can partially restore myogenesis.
Review
Biochemistry & Molecular Biology
Ruolan Liu, Liyuan Peng, Li Zhou, Zhao Huang, Chengwei Zhou, Canhua Huang
Summary: Immunotherapy is a revolutionary treatment option for cancer, but only a subset of patients respond durably. Recent studies have shown that oxidative stress induced by reactive oxygen species (ROS) plays a crucial role in the tumor immune response, thus influencing immunotherapeutic effects. This study summarizes cancer immunotherapeutic strategies, discusses the interplay between oxidative stress and anticancer immunity, and highlights the molecular mechanisms underlying the regulation of treatment response to cancer immunotherapy by oxidative stress. The therapeutic opportunities of manipulating oxidative stress to improve the antitumor immune response are also emphasized.
Review
Biochemistry & Molecular Biology
Yu-Ting Zhu, Cheng Wan, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang
Summary: Podocytopathies are kidney diseases driven by podocyte injury. This review highlights the crucial role of mitochondrial oxidative stress in the pathogenesis of podocytopathies and its relationship with cell death in podocytes. Exogenous antioxidants can protect podocytes from damage. The review aims to identify new targets for improving the treatment of podocytopathies.
Article
Food Science & Technology
Juanjuan Wei, Yurong Li, Zimao Ye, Yi Li, Zhiqin Zhou
Summary: Citrus carotenoids have antioxidant and anticancer properties, making them potentially effective in the prevention and treatment of breast cancer. Different citrus species contain abundant carotenoids, which exhibit good antioxidant and anticancer activities. Citrus carotenoids can induce cell oxidative stress and regulate cell apoptosis, showing potential for the development of anti-breast cancer products.
Article
Biochemistry & Molecular Biology
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung
Summary: Researchers found that TSLP can regulate ROS production and mitophagy through AMPK activation and histone modification, thus affecting the expression of M1/M2 chemokines in human monocytes.
CELL AND BIOSCIENCE
(2022)
Article
Acoustics
Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin, Chia -Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni Misran, Lip Yong Chung, Dar-Bin Shieh, Lik Voon Kiew, Chia-Ching Chang, Yin Yin Teo
Summary: Gold nanorods coated with alginate (AuNRsALG) are found to be promising nanosonosensitisers for sonodynamic therapy (SDT) due to their enhanced singlet oxygen generation and efficient cancer cell killing effect, primarily through apoptosis.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Salvatore Antonucci, Moises Di Sante, Federica Tonolo, Laura Pontarollo, Valeria Scalcon, Petra Alanova, Roberta Menabo, Andrea Carpi, Alberto Bindoli, Maria Pia Rigobello, Marco Giorgio, Nina Kaludercic, Fabio Di Lisa
Summary: The study demonstrates the crucial role of monoamine oxidases (MAOs) in oxidative stress and mitochondrial dysfunction in doxorubicin cardiomyopathy. Pharmacological inhibition of MAOs can alleviate the dysfunctions leading to cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman, MD. Hasanur Rahman, Partha Biswas, Md. Shahadat Hossain, Rokibul Islam, Md. Abdul Hannan, Md Jamal Uddin, Hyewhon Rhim
Summary: Mitochondrial dysfunction is a potential cause of AD, which may be triggered by mutations in mitochondrial or nuclear DNA, resulting in an imbalance in reactive oxygen species production and oxidative stress. Neuroinflammation may also induce mitochondrial dysfunction. Phytochemicals have the potential to scavenge oxygen free radicals, enhance cellular antioxidant defense systems, and modulate other cellular processes, making them a potential strategy for alleviating mitochondrial dysfunction in the pathogenesis of AD.
Article
Biochemistry & Molecular Biology
Carlos Sanchez-Martin, Daniela Menon, Elisabetta Moroni, Mariarosaria Ferraro, Ionica Masgras, Justin Elsey, Jack L. Arbiser, Giorgio Colombo, Andrea Rasola
Summary: The study uncovers HDCA as a potential TRAP1 selective inhibitor for use in antineoplastic therapy in tumor cells, by reversing TRAP1-dependent downregulation of SDH, reducing tumor cell proliferation rates, increasing mitochondrial superoxide levels, and abolishing tumorigenic growth.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Oncology
Federica Chiara, Stefano Indraccolo, Andrea Trevisan
Summary: Over the past two decades, studies have linked tumor onset to environmental exposure to carcinogens, shifting focus from solely mutational burden to a more complex understanding of the factors involved in tumor formation. Consequently, traditional risk assessment strategies based on the 'mutator model' require urgent updates in order to keep pace with advances in our understanding of cancer biology.
Article
Cell Biology
Francesca Zonta, Christian Borgo, Camila Paz Quezada Meza, Ionica Masgras, Andrea Rasola, Mauro Salvi, Lorenzo A. Pinna, Maria Ruzzene
Summary: CK2, an overexpressed Ser/Thr protein kinase in many cancers, plays a crucial role in the uncontrolled proliferation, motility, and survival of cancer cells. This study reveals that both CK2 alpha and alpha' isoforms contribute to cell proliferation, survival, and tumorigenicity, with a prominent role for CK2 alpha in tumor metabolism.
Review
Biochemistry & Molecular Biology
Francesco Ciscato, Lavinia Ferrone, Ionica Masgras, Claudio Laquatra, Andrea Rasola
Summary: Hexokinases, particularly Hexokinase 2 (HK2), play a critical role in glucose metabolism and are highly expressed in insulin-sensitive tissues and neoplastic cells. In addition to its enzymatic activity, HK2 can regulate autophagy and cell death, as well as intracellular Ca2+ fluxes, at the mitochondria-associated membranes (MAMs). Targeting HK2 subcellular localization in MAMs may offer a promising anti-tumor strategy by disrupting its functions in metabolic and survival pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Andrea Errico, Anna Stocco, Vincent M. Riccardi, Alberto Gambalunga, Franco Bassetto, Martina Grigatti, Amedeo Ferlosio, Gianluca Tadini, Debora Garozzo, Stefano Ferraresi, Andrea Trevisan, Sandra Giustini, Andrea Rasola, Federica Chiara
Summary: Neurofibromatosis type 1 is a genetic disease that predisposes to tumors of the nervous system, primarily neurofibroma. Research has shown that cell-cell cooperativity and the dynamics of the extracellular matrix play important roles in the progression of the disease, and treatment with MEK and FAK inhibitors has shown promise in abolishing the transforming ability of Pnf cells.
Article
Multidisciplinary Sciences
Andrea Carrer, Ludovica Tommasin, Justina Sileikyte, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildiko Szabo, Michela Carraro, Paolo Bernardi
Summary: The nature of the mitochondrial permeability transition pore (PTP) remains debated, with the possibility that it can be mediated by F-ATP synthase or adenine nucleotide translocator. Through genetic modifications and cell experiments, researchers identified the essential role of certain mitochondrial subunits in turning the F-ATP synthase into the PTP, and showed that the ANT can contribute to channel formation in the absence of an assembled F-ATP synthase.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ionica Masgras, Giuseppe Cannino, Francesco Ciscato, Carlos Sanchez-Martin, Fereshteh Babaei Darvishi, Francesca Scantamburlo, Marco Pizzi, Alessio Menga, Dolores Fregona, Alessandra Castegna, Andrea Rasola
Summary: The loss of neurofibromin leads to the growth of tumors and a rewiring of mitochondrial metabolism. This study found that the depletion of neurofibromin inhibits the expression and activity of NADH dehydrogenase, reducing respiration and intracellular NAD(+) levels in an ERK-dependent manner. However, the expression of alternative NADH dehydrogenase NDI1 increases the NAD(+)/NADH ratio and enhances the activity of the NAD(+)-dependent deacetylase SIRT3, impairing tumorigenicity in neurofibromin-deficient cells. Additionally, mimicking the antineoplastic effect of NDI1 can be achieved through the administration of NAD(+) precursors or increasing the expression of the NAD(+) deacetylase SIRT3, and this effect is synergistic with the depletion of the mitochondrial chaperone TRAP1 and its enhancement of succinate dehydrogenase activity.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Giuseppe Cannino, Andrea Urbani, Marco Gaspari, Mariaconcetta Varano, Alessandro Negro, Antonio Filippi, Francesco Ciscato, Ionica Masgras, Christoph Gerle, Elena Tibaldi, Anna Maria Brunati, Giorgio Colombo, Giovanna Lippe, Paolo Bernardi, Andrea Rasola
Summary: This study reveals that the mitochondrial chaperone TRAP1 interacts with F-ATP synthase, increasing its catalytic activity and counteracting the inhibitory effect of CyPD. Additionally, TRAP1 directly inhibits the channel activity of F-ATP synthase and reverses PTP induction by CyPD, thus preventing mitochondrial depolarization and cell death. These findings highlight the importance of TRAP1 in cell bioenergetics and survival.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Marco Fonzo, Annamaria Nicolli, Stefano Maso, Lorenzo Carrer, Andrea Trevisan, Chiara Bertoncello
Summary: This study investigated the relationship between overweight/obesity and antibody persistence after vaccination against measles, mumps, rubella (MMR), and hepatitis B virus (HBV). The results showed that there was no significant association between lack of serologic protection and BMI for both HBV vaccine and each component of the MMR vaccine.
Article
Immunology
Marco Fonzo, Chiara Bertoncello, Andrea Trevisan
Summary: This study aimed to assess long-term protection 10-20 years after primary HBV vaccination and investigate the effects of age at first dose, sex, and time between doses. The results showed that early vaccination had a better long-term protective effect, while the impact on vaccination in adolescence was not significant.
Article
Immunology
Paola Mason, Rosario Rizzuto, Luca Iannelli, Flavio Baccaglini, Valerio Rizzolo, Andrea Baraldo, Barbara Melloni, Francesca Maffione, Camilla Pezzoli, Maria Laura Chiozza, Giampietro Rupolo, Marco Biasioli, Filippo Liviero, Maria Luisa Scapellato, Andrea Trevisan, Stefano Merigliano, Alberto Scuttari, Angelo Moretto, Bruno Scarpa
Summary: This study investigated the adverse effects of two SARS-CoV-2 vaccines in a real-life preventive setting at the University of Padova in Italy. It was found that the ChAdOx1 nCoV-19 vaccine caused more adverse effects after the first dose, while the BNT162b2 vaccine caused more adverse effects after the second dose.
Letter
Oncology
Damanti Carlotta Caterina, Ferrone Lavinia, Gaffo Enrico, Garbin Anna, Tosato Anna, Contarini Giorgia, Gallingani Ilaria, Angioni Roberta, Molon Barbara, Borile Giulia, Carraro Elisa, Pillon Marta, Scarmozzino Federico, Dei Tos Angelo Paolo, Pizzi Marco, Ciscato Francesco, Rasola Andrea, Biffi Alessandra, Bortoluzzi Stefania, Lovisa Federica, Mussolin Lara
CANCER COMMUNICATIONS
(2023)
Article
Biology
Francesco Ciscato, Federica Chiara, Riccardo Filadi, Andrea Rasola
Summary: The crucial role of HK2 in metabolic rewiring of tumors is well established, and a targeted peptide named HK2pep has been designed to detach HK2 and reduce tumor mass effectively.
