Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis

(2019) Chiara Fedeli et al.   Autophagy

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer

(2018) Nicholas S. Akins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL

(2018) Kavita Bhalla et al.   Scientific Reports

Metabolic Plasticity of Tumor Cell Mitochondria

(2018) Giuseppe Cannino et al.   Frontiers in Oncology

Aberrant expression of CD10 and BCL6 in mantle cell lymphoma

(2017) Marco Pizzi et al.   HISTOPATHOLOGY

Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression

(2017) Kyle J. Isaacson et al.   JOURNAL OF CONTROLLED RELEASE

Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development

(2017) Juan J. Gu et al.   Oncotarget

Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1

(2017) Ionica Masgras et al.   Cell Reports

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Cell-penetrating peptides: strategies for anticancer treatment

(2015) Drazen Raucher et al.   TRENDS IN MOLECULAR MEDICINE

Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole

(2014) Federica Frezzato et al.   BRITISH JOURNAL OF HAEMATOLOGY

The mitochondrial permeability transition pore and its adaptive responses in tumor cells

(2014) Andrea Rasola et al.   CELL CALCIUM

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

(2014) David J. Roberts et al.   MOLECULAR CELL

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer

(2013) Dong Hoon Suh et al.   CLINICAL AND EXPERIMENTAL MEDICINE

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface

(2013) B Pantic et al.   Cell Death & Disease

Induction of the permeability transition pore in cells depleted of mitochondrial DNA

(2012) Ionica Masgras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

(2009) Emilia S. Olson et al.   Integrative Biology

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY