Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy

(2016) Rachid Rezgui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hexokinase 2 is a determinant of neuroblastoma metastasis

(2016) Liat Edry Botzer et al.   BRITISH JOURNAL OF CANCER

Carbon nanotubes from synthesis to in vivo biomedical applications

(2016) Muhammad Imran Sajid et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity

(2016) Reem Alshehri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Uptake Mechanism and Direct Translocation of a New CPP for siRNA Delivery

(2016) Ran Pan et al.   MOLECULAR PHARMACEUTICS

Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells

(2015) Sia Lee Yoong et al.   Nanoscale

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

A Quantitative Method to Track Protein Translocation between Intracellular Compartments in Real-Time in Live Cells Using Weighted Local Variance Image Analysis

(2013) Guillaume Calmettes et al.   PLoS One

Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans

(2012) Helene L. Åmand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of the Attachment of a Penetration Accelerating Sequence and the Influence of Hydrophobicity on Octaarginine-Mediated Intracellular Delivery

(2012) Kentaro Takayama et al.   MOLECULAR PHARMACEUTICS

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Enzymatic properties of the N- and C-terminal halves of human hexokinase II

(2011) Keun-Jae Ahn et al.   BMB Reports

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

Analysis of oligo-arginine cell-permeable peptides uptake by prostate cells

(2010) Jian Zhou et al.   AMINO ACIDS

3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy

(2010) S. Ganapathy-Kanniappan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma

(2010) Alejandro G. Levy et al.   INVESTIGATIONAL NEW DRUGS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas)

(2009) Kentaro Takayama et al.   JOURNAL OF CONTROLLED RELEASE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment’s roles together with hexokinase-2 in the “Warburg effect” in cancer

(2008) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Selective Enhancement of the Uptake and Bioactivity of a TAT-conjugated Peptide Inhibitor of Glycogen Synthase Kinase-3

(2008) Aziza P Manceur et al.   MOLECULAR THERAPY

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY