Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy

VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties

(2017) Tasleem Arif et al.   NEURO-ONCOLOGY

Mitochondrial VDAC1-based peptides: Attacking oncogenic properties in glioblastoma

(2017) Anna Shteinfer-Kuzmine et al.   Oncotarget

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

D-Peptides as Recognition Molecules and Therapeutic Agents

(2016) Min Liu et al.   CHEMICAL RECORD

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Histological and Histochemical Methods: Theory and Practice, 5thedition

(2015) Jim Elsam   BIOTECHNIC & HISTOCHEMISTRY

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction

(2014) Shira Weisthal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis

(2013) Nurit Keinan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

Human breast and melanoma cancer stem cells biomarkers

(2012) Caterina A.M. La Porta et al.   CANCER LETTERS

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cancer Stem-Cell Hypothesis: Its Emerging Role in Lung Cancer Biology and Its Relevance for Future Therapy

(2012) John D. O’Flaherty et al.   Journal of Thoracic Oncology

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Transmembrane helix–helix interactions are modulated by the sequence context and by lipid bilayer properties

(2011) Florian Cymer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Apoptosis and oncogenesis: give and take in the BCL-2 family

(2011) Fabien Llambi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity

(2010) Tina Holm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity

(2010) Lin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The therapeutic promise of the cancer stem cell concept

(2010) Natasha Y. Frank et al.   JOURNAL OF CLINICAL INVESTIGATION

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Clues from cell metabolism

(2010) William G. Kaelin et al.   NATURE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity

(2009) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Anti-cancer drugs interfere with intracellular calcium signaling

(2009) Ana-Maria Florea et al.   NEUROTOXICOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase

(2008) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide

(2008) Steve Oh et al.   CANCER LETTERS

Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor

(2008) X. Cao et al.   CLINICAL CANCER RESEARCH

Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1

(2008) Salah Abu-Hamad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity

(2008) Laetitia Arzoine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

(2008) N Goldin et al.   ONCOGENE

Disruption of the hexokinase–VDAC complex for tumor therapy

(2008) L Galluzzi et al.   ONCOGENE

Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

(2008) N Tajeddine et al.   ONCOGENE