Natural and synthetic flavonoid modulation of TRPC5 channels

(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

(2015) Yasemin Akbulut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

(2015) Yingmin Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

(2014) Helgi I. Ingólfsson et al.   ACS Chemical Biology

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance

(2014) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

(2013) Robin S Bon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Riluzole activates TRPC5 channels independently of PLC activity

(2013) Julia M Richter et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(2013) David J. Beech   CIRCULATION JOURNAL

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Inhibition of endothelial cell Ca2+entry and transient receptor potential channels by Sigma-1 receptor ligands

(2012) Mohamed S Amer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin

(2012) Piruthivi Sukumar et al.   CIRCULATION RESEARCH

Alpinia officinarum Inhibits Adipocyte Differentiation and High-Fat Diet–Induced Obesity in Mice Through Regulation of Adipogenesis and Lipogenesis

(2012) Chang Hwa Jung et al.   JOURNAL OF MEDICINAL FOOD

The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels

(2011) S Saponara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel

(2011) Xin Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1

(2011) L. H. Jiang et al.   CURRENT DRUG TARGETS

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positioning of Antioxidant Quercetin and Its Metabolites in Lipid Bilayer Membranes: Implication for Their Lipid-Peroxidation Inhibition

(2011) Pavlína Košinová et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases

(2010) Ching-On Wong et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes

(2010) Jacqueline Naylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

(2010) Joachim Goedhart et al.   NATURE METHODS

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Kaempferol stimulates large conductance Ca2+-activated K+(BKCa) channels in human umbilical vein endothelial cells via a cAMP/PKA-dependent pathway

(2008) Y C Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of TRPC5 cation channels by halothane, chloroform and propofol

(2008) Y M Bahnasi et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPs in Our Senses

(2008) Nils Damann et al.   CURRENT BIOLOGY

Herbal Compounds and Toxins Modulating TRP Channels

(2008) Rudi Vennekens et al.   Current Neuropharmacology

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

(2005) Shang-Zhong Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY