Cell Death in Liver Diseases: A Review

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity

(2020) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Indoleamine 2, 3-dioxygenase 1enhanceshepatocytes ferroptosis in acute immune hepatitis associated with excess nitrative stress

(2020) Ting Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeted Apoptosis Of Ductular Reactive Cells Reduces Hepatic Fibrosis In A Mouse Model of Cholestasis

(2020) Adiba I. Azad et al.   HEPATOLOGY

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

(2020) Wan-feng Xu et al.   ACTA PHARMACOLOGICA SINICA

Role of ferroptosis in acetaminophen-induced hepatotoxicity

(2020) Naoya Yamada et al.   ARCHIVES OF TOXICOLOGY

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

(2020) Xiaoqin Wu et al.   JOURNAL OF HEPATOLOGY

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

(2020) Xiaoya Li et al.   LIVER INTERNATIONAL

NLRP3 receptor contributes to protection against experimental antigen-mediated cholangitis

(2020) Marisol Ibet González et al.   BIOSCIENCE REPORTS

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies

(2020) Chenxia Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intrahepatocytic necroptosis is dispensable for hepatocyte death in murine immune-mediated hepatitis

(2020) Annaïg Hamon et al.   JOURNAL OF HEPATOLOGY

The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

(2020) Lihong Mao et al.   Cell Death & Disease

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Parimal Samir et al.   Frontiers in Cellular and Infection Microbiology

Circulating Receptor-Interacting Protein Kinase 3 Are Increased in HBV Patients With Acute-on-Chronic Liver Failure and Are Associated With Clinical Outcome

(2020) Liwen Chen et al.   Frontiers in Physiology

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

(2020) Min Wang et al.   Cell Death & Disease

Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis

(2019) Muhammad Farooq et al.   Cell Death & Disease

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation

(2019) Haixia Xu et al.   Molecular Metabolism

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

(2019) Jessica Maiers et al.   SEMINARS IN LIVER DISEASE

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

(2019) Daniel Frank et al.   JOURNAL OF CELL SCIENCE

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

(2019) Lijun Liao et al.   GUT

Targeting RIPK1 for the treatment of human diseases

(2019) Alexei Degterev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

(2019) Chenxuan Yang et al.   Cell Death & Disease

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models

(2019) Joseph Kuo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids

(2019) Benjamin L. Woolbright et al.   GENE EXPRESSION

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

(2019) Amine Majdi et al.   JOURNAL OF HEPATOLOGY

Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages

(2019) Hong Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of autophagy in alcohol and drug-induced liver injury

(2019) Jessica A. Williams et al.   FOOD AND CHEMICAL TOXICOLOGY

Caveolin-1 dictates ferroptosis in the execution of acute immune-mediated hepatic damage by attenuating nitrogen stress

(2019) Guanghui Deng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

(2019) Guadalupe Garcia-Tsao et al.   JOURNAL OF HEPATOLOGY

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Caspases in metabolic disease and their therapeutic potential

(2018) Claire H Wilson et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The role of apoptosis in acetaminophen hepatotoxicity

(2018) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

(2018) Anup Ramachandran et al.   GENE EXPRESSION

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis

(2018) Xiaolei Wang et al.   HEPATOLOGY

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Preclinical models of non-alcoholic fatty liver disease

(2018) Prasanna K. Santhekadur et al.   JOURNAL OF HEPATOLOGY

SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy

(2018) Yan You et al.   JOURNAL OF HEPATOLOGY

Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation

(2018) Akiko Eguchi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Receptor Interacting Protein Kinases in the Liver

(2018) Lily Dara   SEMINARS IN LIVER DISEASE

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

(2018) Anna Moles et al.   Frontiers in Pharmacology

NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

(2018) Jingyun Luan et al.   Frontiers in Immunology

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice

(2018) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PATHOLOGY

Inactivation of Caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis

(2018) Francisco Javier Cubero et al.   JOURNAL OF HEPATOLOGY

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

(2018) Laura Faletti et al.   Cell Death & Disease

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease

(2018) Mitchell Shiffman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

PUMA induction mediates acetaminophen‐induced necrosis and liver injury

(2018) Dongshi Chen et al.   HEPATOLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Interleukin-10 secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis

(2017) Jinglin Wang et al.   HEPATOLOGY RESEARCH

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

(2017) Andrea Iorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury

(2017) Peixiang Lan et al.   JOURNAL OF CLINICAL INVESTIGATION

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

(2017) Aveline Filliol et al.   JOURNAL OF HEPATOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

(2017) Fengjie Hao et al.   Cell Death & Disease

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

(2017) Jun Zhang et al.   Cell Death & Disease

The Activation and Function of Autophagy in Alcoholic Liver Disease

(2017) Bilon Khambu et al.   Current Molecular Pharmacology

A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

(2016) Shaogui Wang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Not All Mice Are the Same: Standardization of Animal Research Data Presentation

(2016) M. Bishr Omary et al.   GASTROENTEROLOGY

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes

(2016) Laura E. Nagy et al.   GASTROENTEROLOGY

Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?

(2016) Jacquelyn J. Maher   HEPATOLOGY

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

A murder mystery in the liver: who done it and how?

(2016) Lily Dara et al.   JOURNAL OF CLINICAL INVESTIGATION

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

(2016) Jo Suda et al.   JOURNAL OF IMMUNOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

(2016) Aveline Filliol et al.   Cell Death & Disease

Activation of necroptosis in human and experimental cholestasis

(2016) Marta B Afonso et al.   Cell Death & Disease

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

(2016) Jérémie Gautheron et al.   Nature Communications

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

(2016) Shaogui Wang et al.   Oncotarget

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

(2016) Zizhen Gong et al.   Oncotarget

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells

(2016) H. M. Kofahi et al.   Scientific Reports

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

(2015) Phillipp Hartmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice

(2015) Jessica A. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

(2015) Jessica A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity

(2015) Neil Kaplowitz et al.   JOURNAL OF HEPATOLOGY

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

(2015) Jan Petrasek et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver

(2015) Muhammad Imran Arshad et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The concanavalin A model of acute hepatitis in mice

(2015) F Heymann et al.   LABORATORY ANIMALS

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications

(2015) Lily Dara et al.   LIVER INTERNATIONAL

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Effects of Cyclosporine on Reperfusion Injury in Patients: A Meta-Analysis of Randomized Controlled Trials

(2015) Kangxing Song et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury

(2015) Jessica A. Williams et al.   PHARMACOLOGICAL RESEARCH

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

(2015) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury

(2015) M Deutsch et al.   Cell Death & Disease

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling

(2015) Young Jun Kang et al.   Nature Communications

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

(2015) Anna Baulies et al.   Scientific Reports

Regulated Cell Death: Signaling and Mechanisms

(2014) Avi Ashkenazi et al.   Annual Review of Cell and Developmental Biology

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease

(2014) Wajahat Zafar Mehal   DIGESTIVE DISEASES

Targeting Apoptosis in Autoimmune Hepatitis

(2014) Albert J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model

(2014) Samjhana Thapaliya et al.   DIGESTIVE DISEASES AND SCIENCES

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Monocytes Activate Natural Killer Cells via Inflammasome-Induced Interleukin 18 in Response to Hepatitis C Virus Replication

(2014) Elisavet Serti et al.   GASTROENTEROLOGY

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice

(2014) Zhuofeng Lin et al.   JOURNAL OF HEPATOLOGY

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

(2013) Kento Imajo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis

(2013) Yoon Seok Roh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study

(2013) Nabil Eid et al.   JOURNAL OF MOLECULAR HISTOLOGY

Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice

(2013) Yingqun Zhou et al.   MEDIATORS OF INFLAMMATION

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver

(2013) Hong-Min Ni et al.   Redox Biology

Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation

(2012) Sanjoy Roychowdhury et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC

(2012) Shah Jahan et al.   INFECTION GENETICS AND EVOLUTION

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

(2011) Mohammed Bourdi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

(2011) Timea Csak et al.   HEPATOLOGY

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Identification of a Cytochrome P4502E1/Bid/C1q-dependent Axis Mediating Inflammation in Adipose Tissue after Chronic Ethanol Feeding to Mice

(2011) Becky M. Sebastian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

(2011) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Inflammasomes: Molecular Effectors of Host Resistance Against Bacterial, Viral, Parasitic, and Fungal Infections

(2011) Alexander Skeldon et al.   Frontiers in Microbiology

Clinical trial: efficacy and safety of oral PF-03491390, a pancaspase inhibitor - a randomized placebo-controlled study in patients with chronic hepatitis C

(2010) M. L. SHIFFMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mechanisms and clinical implications of hepatocyte lipoapoptosis

(2010) Sophie C Cazanave et al.   Clinical Lipidology

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

Stress Signaling in the Methionine-Choline–Deficient Model of Murine Fatty Liver Disease

(2010) Russell K. Soon et al.   GASTROENTEROLOGY

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

(2010) Hartmut Jaeschke et al.   HEPATOLOGY

CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity

(2010) Bin Hu et al.   HEPATOLOGY

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

(2010) Mie Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C

(2010) Tarik Asselah et al.   JOURNAL OF PATHOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling--a propensity score-adjusted observational study

(2010) L. Valenti et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cyclophilin D in mitochondrial pathophysiology

(2009) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Cellular and Molecular Mechanisms of Liver Injury

(2008) Harmeet Malhi et al.   GASTROENTEROLOGY

Caspase activation is associated with spontaneous recovery from acute liver failure

(2008) Xandra Volkmann et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA