Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications

The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1–/– Mice Cotreated with Anti-CTLA-4

(2015) Alastair Mak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Inhibition of immune tolerance unmasks drug-induced allergic hepatitis

(2015) Jack Uetrecht et al.   HEPATOLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment

(2015) Mala Chakraborty et al.   HEPATOLOGY

Ipilimumab-induced toxicities and the gastroenterologist

(2015) Robert Cheng et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

From immunosuppression to tolerance

(2015) David H. Adams et al.   JOURNAL OF HEPATOLOGY

Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice

(2015) Guruprasad P. Aithal   LIVER INTERNATIONAL

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Mechanisms of drug-induced liver injury

(2014) Camilla Stephens et al.   Current Opinion in Allergy and Clinical Immunology

Rheumatoid arthritis complicated with severe liver injury during treatment with abatacept

(2014) Nozomi Iwanaga et al.   Modern Rheumatology

Avoiding idiosyncratic DILI: Two is better than one

(2013) Neil Kaplowitz   HEPATOLOGY

Ipilimumab associated hepatitis: imaging and clinicopathologic findings

(2013) Kyung Won Kim et al.   INVESTIGATIONAL NEW DRUGS

Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid

(2013) R. M. Dunham et al.   JOURNAL OF IMMUNOLOGY

The Price of Tumor Control: An Analysis of Rare Side Effects of Anti-CTLA-4 Therapy in Metastatic Melanoma from the Ipilimumab Network

(2013) Caroline J. Voskens et al.   PLoS One

The scavenger endothelial cell: a new player in homeostasis and immunity

(2012) Karen Kristine Sørensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pathologic Changes in Ipilimumab-Related Hepatitis in Patients with Metastatic Melanoma

(2012) David E. Kleiner et al.   DIGESTIVE DISEASES AND SCIENCES

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

(2011) Frank A. Schildberg et al.   HEPATOLOGY

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Mechanistic insights into immunomodulation by hepatic stellate cells in mice: A critical role of interferon-γ signaling

(2009) Horng-Ren Yang et al.   HEPATOLOGY

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

(2009) Ekaterina Breous et al.   HEPATOLOGY

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of IL-10, IL-4 and TNF-α polymorphisms in drug-induced liver injury (DILI) and its outcome

(2008) Ketevan Pachkoria et al.   JOURNAL OF HEPATOLOGY

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

(2008) Jorge R. Oksenberg et al.   NATURE REVIEWS GENETICS