Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

(2012) Daniel J. Antoine et al.   JOURNAL OF HEPATOLOGY

ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis

(2012) Junfeng An et al.   JOURNAL OF HEPATOLOGY

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation

(2011) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

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(2010) Daniel Antoine et al.   MOLECULAR MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The molecular regulation of programmed necrotic cell injury

(2010) David Moquin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY