The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

(2017) Kyle S. McCommis et al.   HEPATOLOGY

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

(2017) Guang-Nian Zhao et al.   NATURE MEDICINE

Vector overcomes barrier to gene therapy delivery

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1

(2017) Johannes F. Weijman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease

(2016) Hitoshi Maruyama et al.   International Journal of Medical Sciences

Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)

(2016) Olivia Petrvalska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis

(2016) Ling Gao et al.   JOURNAL OF HEPATOLOGY

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

(2016) Mei Xiang et al.   JOURNAL OF HEPATOLOGY

DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity

(2016) Lanfeng Xie et al.   JOURNAL OF HEPATOLOGY

Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2

(2016) Dewei Ye et al.   JOURNAL OF HEPATOLOGY

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

(2016) L Catrysse et al.   Cell Death & Disease

Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

(2016) Pi-Xiao Wang et al.   Nature Communications

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

(2016) Yan-Xiao Ji et al.   Nature Communications

Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

(2016) Ke-Qiong Deng et al.   Nature Communications

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration

(2015) P Studer et al.   CELL DEATH AND DIFFERENTIATION

Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function

(2015) Q. Huang et al.   CIRCULATION

A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis

(2015) Luoyan Ai et al.   International Journal of Biological Sciences

Mindin deficiency protects the liver against ischemia/reperfusion injury

(2015) Peng Sun et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury

(2015) Pi-Xiao Wang et al.   JOURNAL OF HEPATOLOGY

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

(2015) Tomohiko Okazaki et al.   Science Signaling

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

(2015) Tomohiko Okazaki et al.   Science Signaling

Dickkopf-3 attenuates pressure overload-induced cardiac remodelling

(2014) Yan Zhang et al.   CARDIOVASCULAR RESEARCH

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease

(2014) Jun Feng et al.   Lipids in Health and Disease

Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis

(2014) Ahmed Lawan et al.   MOLECULAR AND CELLULAR BIOLOGY

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

(2014) T. Maruyama et al.   Science Signaling

Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells

(2013) Min-Bin Chen et al.   CELLULAR SIGNALLING

Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme

(2013) Timothy T. Lu et al.   IMMUNITY

Obesity Notches up fatty liver

(2013) Michael P Czech   NATURE MEDICINE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

(2010) M Won et al.   CELL DEATH AND DIFFERENTIATION

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Tumor Suppressor A20 Protects Against Cardiac Hypertrophy and Fibrosis by Blocking Transforming Growth Factor-β–Activated Kinase 1–Dependent Signaling

(2010) He Huang et al.   HYPERTENSION

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

(2010) Ivan Bosanac et al.   MOLECULAR CELL

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

(2010) Y. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells

(2009) Arpad Boronkai et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

(2009) Barbara A. Malynn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-α expression

(2009) Haley E. Ramsey et al.   LIVER TRANSPLANTATION

A20: Central Gatekeeper in Inflammation and Immunity

(2008) Beatrice Coornaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

(2008) Emre E. Turer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE