Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Serum Cytokeratin-18 Fragment Levels Are Useful Biomarkers for Nonalcoholic Steatohepatitis in Children

(2013) Ariel E Feldstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation

(2012) Sanjoy Roychowdhury et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Necroptosis: An emerging form of programmed cell death

(2011) Wei Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

(2011) Christian Liedtke et al.   GASTROENTEROLOGY

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

NASH animal models: Are we there yet?

(2011) Rohit Kohli et al.   JOURNAL OF HEPATOLOGY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Complement and Alcoholic Liver Disease: Role of C1q in the Pathogenesis of Ethanol-Induced Liver Injury in Mice

(2010) Jessica I. Cohen et al.   GASTROENTEROLOGY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

(2009) Achim Weber et al.   HEPATOLOGY

Receptor Interacting Protein 3 Suppresses Vascular Smooth Muscle Cell Growth by Inhibition of the Phosphoinositide 3-Kinase-Akt Axis

(2009) Qian Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY