Hedgehog Signaling: Implications in Cancers and Viral Infections

Concurrent Control of KSHV Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: A New Prospect to the Therapeutic Potential of Lipoxin A4

(2020) Kumari Asha et al.   JOURNAL OF VIROLOGY

The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses

(2020) Burthia E. Booker et al.   CANCER BIOLOGY & THERAPY

Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?

(2019) Moussab Tatfi et al.   Frontiers in Immunology

Gli Proteins: Regulation in Development and Cancer

(2019) Paweł Niewiadomski et al.   Cells

Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy

(2019) Valentina Montagnani et al.   Cancers

Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter

(2019) Di Qu et al.   NUCLEIC ACIDS RESEARCH

Structural optimization on a virtual screening hit of smoothened receptor

(2019) Shiwei Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer

(2019) Verónica Rojo-León et al.   EXPERIMENTAL CELL RESEARCH

Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway

(2019) Sneha Priya Aravinth et al.   LEUKEMIA & LYMPHOMA

Hepatitis C Virus Infection and Cholangiocarcinoma

(2019) Maria-Cristina Navas et al.   AMERICAN JOURNAL OF PATHOLOGY

Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus

(2019) Ricardo Rivera-Soto et al.   Frontiers in Microbiology

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis

(2018) Mohammed Benkheil et al.   BIOCHEMICAL PHARMACOLOGY

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

(2018) Syeda Kiran Riaz et al.   Cell Communication and Signaling

Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma

(2018) Christina Sternberg et al.   INTERNATIONAL JOURNAL OF CANCER

VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications

(2018) Khaled Alkharsah   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

(2018) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the PI3K‑AKT‑mTOR pathway in hepatitis B virus infection and replication

(2018) Kunlun Xiang et al.   Molecular Medicine Reports

Inflammatory signatures distinguish metabolic health in African American women with obesity

(2018) Gerald V. Denis et al.   PLoS One

Salmonella Enteritidis ST183: emerging and endemic biotypes affecting western European hedgehogs (Erinaceus europaeus) and people in Great Britain

(2018) Becki Lawson et al.   Scientific Reports

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis

(2018) Lucas E. Cavallin et al.   PLoS Pathogens

Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection

(2018) Xin Shi et al.   Frontiers in Immunology

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome

(2018) Jeffrey I. Cohen   Frontiers in Immunology

Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers

(2018) Maria Lina Tornesello et al.   Cancers

Role of Pattern Recognition Receptors in KSHV Infection

(2018) Timsy Uppal et al.   Cancers

Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

(2018) Maja Sabol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance

(2018) Etienne Giroux-Leprieur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatitis B spliced protein (HBSP) suppresses Fas-mediated hepatocyte apoptosis via activation of PI3K/Akt signaling

(2018) Shu-Xiang Wu et al.   JOURNAL OF VIROLOGY

Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection

(2018) Caroline M. Percopo et al.   JOURNAL OF IMMUNOLOGY

p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation

(2018) Donghui Liu et al.   LABORATORY INVESTIGATION

Targeted Therapy for EBV-associated B-cell Neoplasms

(2018) Siddhartha Ganguly et al.   MOLECULAR CANCER RESEARCH

Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells

(2018) Ita Novita Sari et al.   Cells

New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors

(2017) Nicole Golob-Schwarzl et al.   EUROPEAN JOURNAL OF CANCER

Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte

(2017) Xiqian Lan et al.   EXPERIMENTAL CELL RESEARCH

Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma

(2017) Teruyuki Kuromi et al.   HUMAN PATHOLOGY

Role of angiopoietin-2, endoglin, and placental growth factor in HIV-associated preeclampsia

(2017) Nokuzola Mbhele et al.   HYPERTENSION IN PREGNANCY

Understanding the Molecular Genetics of Basal Cell Carcinoma

(2017) Cristina Pellegrini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas

(2017) Yurie Mikami et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction

(2017) Sepideh Sheybani-Deloui et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling

(2017) Arpit Dheeraj et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Epigenetic Regulation of Viral Biological Processes

(2017) Lata Balakrishnan et al.   Viruses-Basel

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

(2017) Jonathan K. Mitchell et al.   mBio

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

(2017) Deepika Neelakantan et al.   Nature Communications

Prognostic role of Gli1 expression in breast cancer: a meta-analysis

(2017) Bilan Wang et al.   Oncotarget

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

(2017) Yongzhen Liu et al.   Scientific Reports

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

(2017) Joseph L. Regan et al.   Cell Reports

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

(2017) Yuhong Han et al.   PLOS BIOLOGY

Influenza NS1 directly modulates Hedgehog signaling during infection

(2017) Margery G. Smelkinson et al.   PLoS Pathogens

Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma

(2017) Prabha Shrestha et al.   PLoS Pathogens

Chemokines and Chemokine Receptors: Accomplices for Human Immunodeficiency Virus Infection and Latency

(2017) Zhuo Wang et al.   Frontiers in Immunology

The hepatitis B virus X protein promotes pancreatic cancer through modulation of the PI3K/AKT signaling pathway

(2016) Yiwen Chen et al.   CANCER LETTERS

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

(2016) Xiaolan Yu et al.   CELL CYCLE

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers

(2016) Abhishek Bhandari et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma

(2016) Daisy PF Tsang et al.   JOURNAL OF PATHOLOGY

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

(2016) Yumi Miyazaki et al.   Molecular Cancer

SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer

(2016) Yongchun Song et al.   TUMOR BIOLOGY

Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs

(2016) YoungHyun Shin et al.   Virology Journal

HBV/HCV dual infection impacts viral load, antibody response, and cytokine expression differently from HBV or HCV single infection

(2016) Fei Chen et al.   Scientific Reports

HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

(2016) M. Granato et al.   Scientific Reports

Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

(2016) Mingjuan Sun et al.   Cell and Bioscience

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection

(2016) Zsolt Toth et al.   PLoS Pathogens

The hedgehog pathway in triple-negative breast cancer

(2016) Joyce G. Habib et al.   Cancer Medicine

Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy

(2016) Elisabeth Enzenhofer et al.   PLoS One

Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh

(2016) A. S. Noman et al.   Scientific Reports

HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling

(2016) Jiao-Jiao Hu et al.   Scientific Reports

Copy number variation of genes involved in the hepatitis C virus-human interactome

(2016) Lucyna Budzko et al.   Scientific Reports

Hedgehog signaling through GLI1 and GLI2 is required for epithelial–mesenchymal transition in human trophoblasts

(2015) Chao Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy

(2015) Laura Di Magno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Involvement of Interleukin 6 in Hepatitis B Viral Infection

(2015) Caixia Xia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients

(2015) Miao He et al.   CLINICAL SCIENCE

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

(2015) Silvia Pandolfi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Host cell mTORC1 is required for HCV RNA replication

(2015) Stefanie Stöhr et al.   GUT

Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer

(2015) S.S. Islam et al.   MOLECULAR CARCINOGENESIS

Regulation of the oncoprotein Smoothened by small molecules

(2015) Hayley J Sharpe et al.   Nature Chemical Biology

Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia

(2015) D Kern et al.   ONCOGENE

Effect of Rab23 on the proliferation and apoptosis in breast cancer

(2015) YALI LIU et al.   ONCOLOGY REPORTS

The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications

(2015) Soo Hee Kim et al.   TUMOR BIOLOGY

Epstein–Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells

(2015) Anindita Deb Pal et al.   VIROLOGY

In vivoepigenetic reprogramming of primary human colon cancer cells enhances metastases

(2015) Grigori Singovski et al.   Journal of Molecular Cell Biology

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

(2015) Michael Cohen et al.   Nature Communications

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2

(2015) Shingo Inaguma et al.   Oncotarget

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells

(2015) Shingo Inaguma et al.   Oncotarget

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

(2015) Annelies Gonnissen et al.   Oncotarget

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

(2015) Bingchen Han et al.   Cell Reports

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(2015) Namrata Bora-Singhal et al.   NEOPLASIA

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer

(2015) Daniel Suzman et al.   Cancers

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

(2015) Komaraiah Palle et al.   Cancers

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

(2015) Tapati Mazumdar et al.   Oncotarget

Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

(2014) Q. Yao et al.   BLOOD

ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2

(2014) Ram Mohan Ram Kumar et al.   BMC CANCER

Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome

(2014) M. Athar et al.   CANCER RESEARCH

Identification of FoxR2 as an Oncogene in Medulloblastoma

(2014) Hideto Koso et al.   CANCER RESEARCH

Helicobacter pylori-induced Sonic Hedgehog Expression is Regulated by NFκB Pathway Activation: The Use of a Novel In vitro Model to Study Epithelial Response to Infection

(2014) Michael A. Schumacher et al.   HELICOBACTER

Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors

(2014) Kaushlendra Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer

(2014) Chunyan Zeng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HIV-1 gp120 Activates the STAT3/Interleukin-6 Axis in Primary Human Monocyte-Derived Dendritic Cells

(2014) M. Del Corno et al.   JOURNAL OF VIROLOGY

Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin

(2014) Jun Won Park et al.   MOLECULAR CARCINOGENESIS

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway

(2014) Amit Kumar et al.   PLoS One

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

(2014) Fritz Aberger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer

(2014) Einar F. Sverrisson et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

(2014) Sean Cuninghame et al.   VIROLOGY

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

Arsenic Trioxide Inhibits the Hedgehog Pathway Which Is Aberrantly Activated in Acute Promyelocytic Leukemia

(2013) Dongguang Yang et al.   ACTA HAEMATOLOGICA

A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity

(2013) Henry H Chang et al.   Cell Host & Microbe

Genes Upregulated in Prostate Cancer Reactive Stroma Promote Prostate Cancer Progression In Vivo

(2013) O. Dakhova et al.   CLINICAL CANCER RESEARCH

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

(2013) Luis A. Milla et al.   INTERNATIONAL JOURNAL OF CANCER

Hedgehog Signaling Pathway in Ovarian Cancer

(2013) Joanna Szkandera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma

(2013) Soo Hee Kim et al.   JOURNAL OF CLINICAL PATHOLOGY

Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity

(2013) Pelagia Foka et al.   JOURNAL OF HEPATOLOGY

Epstein-Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells

(2013) Rebecca J Port et al.   JOURNAL OF PATHOLOGY

Kaposi's Sarcoma-Associated Herpesvirus Induces the ATM and H2AX DNA Damage Response Early during De Novo Infection of Primary Endothelial Cells, Which Play Roles in Latency Establishment

(2013) V. V. Singh et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Transcytosis through Polarized Oral Epithelial Cells

(2013) S. M. Tugizov et al.   JOURNAL OF VIROLOGY

Sonic Hedgehog (Shh) Regulates the Expression of Angiogenic Growth Factors in Oxygen–Glucose-Deprived Astrocytes by Mediating the Nuclear Receptor NR2F2

(2013) Yanan Li et al.   MOLECULAR NEUROBIOLOGY

Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis

(2013) M Rajurkar et al.   ONCOGENE

Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets

(2013) Mohamad El-Zaatari et al.   PLoS One

Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source

(2013) Constanza Martínez et al.   PLoS One

Hedgehog/GLI Signaling Activates Suppressor of Cytokine Signaling 1 (SOCS1) in Epidermal and Neural Tumor Cells

(2013) Sandra Laner-Plamberger et al.   PLoS One

Gastric cancer (GC) patients with hedgehog pathway activation: PTCH1 and GLI2 as independent prognostic factors

(2013) Su Jin Lee et al.   Targeted Oncology

Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies

(2013) Arun George Paul et al.   Translational Research

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

(2013) Aadra P. Bhatt et al.   Frontiers in Immunology

Variable Expression of GLIPR1 Correlates with Invasive Potential in Melanoma Cells

(2013) Anshul Awasthi et al.   Frontiers in Oncology

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors

(2012) C. L. Cooper et al.   BLOOD

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

(2012) S. Blotta et al.   BLOOD

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft

(2012) Junsheng Fu et al.   CANCER LETTERS

Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein

(2012) A. Arzumanyan et al.   CANCER RESEARCH

Cancer Angiogenesis Induced by Kaposi Sarcoma-Associated Herpesvirus Is Mediated by EZH2

(2012) M. He et al.   CANCER RESEARCH

Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity

(2012) D. L. Fei et al.   CANCER RESEARCH

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

(2012) Cuiping Yang et al.   CELL RESEARCH

Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner

(2012) Sumin Chi et al.   CELLULAR SIGNALLING

Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12

(2012) Anup Kumar Singh et al.   CYTOKINE & GROWTH FACTOR REVIEWS

GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

(2012) Javier Lopez-Rios et al.   DEVELOPMENTAL CELL

STAT3 activation and aberrant ligand-dependent sonic hedgehog signaling in human pulmonary adenocarcinoma

(2012) Qin Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-Kinase/Myosin phosphatase target pathway

(2012) Wei Ma et al.   HEPATOLOGY

Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxia-inducible factor-1α axis under hypoxic conditions

(2012) Mitsuhiko Abe et al.   HEPATOLOGY RESEARCH

Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry

(2012) Zhe Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Multifunctional Angiogenin To Utilize Its Antiapoptotic Functions

(2012) N. Paudel et al.   JOURNAL OF VIROLOGY

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas

(2012) G Sarek et al.   ONCOGENE

Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment

(2012) Carole Y. Perrot et al.   PHARMACOLOGY & THERAPEUTICS

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 Contribute to Sonic Hedgehog-Induced In Vitro Cerebral Angiogenesis

(2012) Hua Teng et al.   PLoS One

Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection

(2012) Stéphane G. Paquette et al.   PLoS One

GLI2 Regulates TGF-β1 in Human CD4+ T Cells: Implications in Cancer and HIV Pathogenesis

(2012) Robert L. Furler et al.   PLoS One

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2

(2012) F. Caccuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

(2012) M. Rajurkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms

(2011) Chi Young Ok et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

(2011) Z I Thomas et al.   BRITISH JOURNAL OF CANCER

Hepatitis B virus X protein stimulates the Hedgehog–Gli activation through protein stabilization and nuclear localization of Gli1 in liver cancer cells

(2011) Hye Young Kim et al.   CANCER LETTERS

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

(2011) T. Mazumdar et al.   CANCER RESEARCH

Cooperative Hedgehog-EGFR signaling

(2011) Doris Mangelberger   Frontiers in Bioscience-Landmark

Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication

(2011) Steve S. Choi et al.   HEPATOLOGY

Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling

(2011) Vassiliki Tzelepi et al.   HISTOPATHOLOGY

Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma

(2011) Wesley O. Greaves et al.   HUMAN PATHOLOGY

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLI3 repressor controls functional development of the mouse ureter

(2011) Jason E. Cain et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61

(2011) L G Harris et al.   ONCOGENE

Overexpression of Hedgehog signaling molecules and its involvement in triple-negative breast cancer

(2011) Lianhong Li   Oncology Letters

KSHV-infected PEL cell lines exhibit a distinct gene expression profile

(2010) Keiji Ueda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia

(2010) Guansong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

At the crossroads of differentiation and proliferation: Precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells

(2010) Stephen Klusza et al.   BIOESSAYS

Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms

(2010) L. Coultas et al.   BLOOD

Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors

(2010) A. Merchant et al.   BLOOD

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

(2010) P. Perez-Galan et al.   BLOOD

Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1

(2010) Ramesh Palaniswamy et al.   BMC MOLECULAR BIOLOGY

The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

(2010) Jan-Bart M. Koorstra et al.   CANCER BIOLOGY & THERAPY

Combinatorial Chemoprevention Reveals a Novel Smoothened-Independent Role of GLI1 in Esophageal Carcinogenesis

(2010) S. Rizvi et al.   CANCER RESEARCH

TGF-  Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

(2010) R. W. Johnson et al.   CANCER RESEARCH

Hedgehog pathway activation in chronic myeloid leukemia: A promise for a novel combination therapeutic approach?

(2010) Zainab Jagani et al.   CELL CYCLE

Coordinated regulation of dorsal bone morphogenetic protein 4 and ventral Sonic hedgehog signaling specifies the dorso-ventral polarity in the optic vesicle and governs ocular morphogenesis through fibroblast growth factor 8 upregulation

(2010) Takuma Kobayashi et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Nanog, Gli, and p53: a new network of stemness in development and cancer

(2010) Sebastian Brandner   EMBO JOURNAL

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Hepatitis B virus/hepatitis C virus upregulate angiopoietin-2 expression through mitogen-activated protein kinase pathway

(2010) Yanmei Li et al.   HEPATOLOGY RESEARCH

Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells

(2010) Marie-Ange Renault et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis and hepatocellular carcinoma

(2010) Thiago de Almeida Pereira et al.   LABORATORY INVESTIGATION

Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation

(2010) R R Singh et al.   LEUKEMIA

Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

(2010) X. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

Sonic Hedgehog/GLI1 signaling pathway inhibition restricts cell migration and invasion in human gliomas

(2010) Ke Wang et al.   NEUROLOGICAL RESEARCH

Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma

(2010) T. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kaposi's Sarcoma Associated Herpes Virus (KSHV) Induced COX-2: A Key Factor in Latency, Inflammation, Angiogenesis, Cell Survival and Invasion

(2010) Neelam Sharma-Walia et al.   PLoS Pathogens

The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms

(2009) S. L. Siggins et al.   BLOOD

Indian hedgehog supports definitive erythropoiesis

(2009) Simon O. Cridland et al.   BLOOD CELLS MOLECULES AND DISEASES

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

(2009) H.-W. Lo et al.   CANCER RESEARCH

Hedgehog signalling in breast cancer

(2009) M. Kasper et al.   CARCINOGENESIS

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Hedgehog signalling as a target in cancer stem cells

(2009) Vanessa Medina et al.   Clinical & Translational Oncology

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Intact Lipid Rafts Regulate HIV-1 Tat Protein-Induced Activation of the Rho Signaling and Upregulation of P-Glycoprotein in Brain Endothelial Cells

(2009) Yu Zhong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells

(2009) B. Chandran   JOURNAL OF VIROLOGY

Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer

(2009) Motoko Seto et al.   MOLECULAR CARCINOGENESIS

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

(2009) Jason E. Cain et al.   PLoS One

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza

(2009) Baoquan Sui et al.   VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Viral IFN Regulatory Factor 3 Stabilizes Hypoxia-Inducible Factor-1  to Induce Vascular Endothelial Growth Factor Expression

(2008) Y. C. Shin et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Characterization of sonic hedgehog as a novel NF-κB target gene that promotes NF-κB-mediated apoptosis resistance and tumor growth in vivo

(2008) Hubert Kasperczyk et al.   FASEB JOURNAL

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

(2008) Wen-Horng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal

(2008) Takashi Shimokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Sensors Ataxia-Telangiectasia Mutated Kinase and Checkpoint Kinase 2 Are Required for Hepatitis C Virus RNA Replication

(2008) Y. Ariumi et al.   JOURNAL OF VIROLOGY

Prognostic significance of EBV-LMP1 and VEGF-A expressions in non-Hodgkin's lymphomas

(2008) Semra Paydas et al.   LEUKEMIA RESEARCH

Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma

(2008) Ganapati V. Hegde et al.   MOLECULAR CANCER THERAPEUTICS

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE