Hedgehog Signaling Pathway in Ovarian Cancer

New in Hedgehog signaling: A possible role in aging, and chronic degenerative and inflammatory diseases? (Comment on DOI 10.1002/bies.201200049)

(2012) Daniel Neureiter   BIOESSAYS

Hedgehog signalling as an antagonist of ageing and its associated diseases

(2012) Monireh Dashti et al.   BIOESSAYS

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission

(2012) S. B. Kaye et al.   CLINICAL CANCER RESEARCH

Current Status of Therapeutic Targeting of Developmental Signalling Pathways in Oncology

(2012) Tobias Kiesslich et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Advances in targeting the Hedgehog signaling pathway in cancer therapy

(2012) Tobias Kiesslich et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Diindolylmethane-mediated Gli1 Protein Suppression Induces Anoikis in Ovarian Cancer Cellsin Vitroand Blocks Tumor Formation Abilityin Vivo

(2012) Prabodh K. Kandala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

(2011) T. Tang et al.   CLINICAL CANCER RESEARCH

Wnt and Hedgehog Gene Pathway Expression in Serous Ovarian Cancer

(2011) Seraina Schmid et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

(2011) Christopher K. McCann et al.   PLoS One

Expression of hedgehog signaling molecules in lung cancer

(2010) Shuhong Huang et al.   ACTA HISTOCHEMICA

Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer

(2010) A. Slusarz et al.   CANCER RESEARCH

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

Aberrant Epithelial–Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia

(2010) David H. Wang et al.   GASTROENTEROLOGY

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of Mammary Tumors by Conditional Expression of GLI1

(2009) M. Fiaschi et al.   CANCER RESEARCH

Hedgehog signalling in breast cancer

(2009) M. Kasper et al.   CARCINOGENESIS

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Ovarian cancer: pathology, biology, and disease models

(2009) Daniel et al.   Frontiers in Bioscience-Landmark

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of hedgehog signaling is not a frequent event in ovarian cancers

(2009) Ling Yang et al.   Molecular Cancer

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

A small molecule that binds Hedgehog and blocks its signaling in human cells

(2009) Benjamin Z Stanton et al.   Nature Chemical Biology

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

(2009) L Yang et al.   ONCOGENE

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Stroma-Initiated Hedgehog Signaling Takes Center Stage in B-Cell Lymphoma

(2008) R. K. Lindemann   CANCER RESEARCH

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

(2008) Xiaoyun Liao et al.   CARCINOGENESIS

Role of Hedgehog Signaling in Ovarian Cancer

(2008) R. Bhattacharya et al.   CLINICAL CANCER RESEARCH

Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

(2008) P.-L. So et al.   MOLECULAR CANCER THERAPEUTICS

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Genome-wide association analysis identifies 20 loci that influence adult height

(2008) Michael N Weedon et al.   NATURE GENETICS

Patched, the receptor of Hedgehog, is a lipoprotein receptor

(2008) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA