Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers

Hepatitis B virus-upregulated lnc-HUR1 promotes cell proliferation and tumorigenesis by blocking p53 activity

(2018) Ningning Liu et al.   HEPATOLOGY

Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment

(2018) Voon Yee-Lin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

(2018) Luis A. Carvajal et al.   Science Translational Medicine

The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets

(2018) Karin Hoppe-Seyler et al.   TRENDS IN MICROBIOLOGY

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

(2018) Samuel Y. Ng et al.   Nature Communications

p53 and the Viral Connection: Back into the Future ‡

(2018) Ronit Aloni-Grinstein et al.   Cancers

Worldwide burden of cancer attributable to HPV by site, country and HPV type

(2017) Catherine de Martel et al.   INTERNATIONAL JOURNAL OF CANCER

The biology of beta human papillomaviruses

(2017) Massimo Tommasino   VIRUS RESEARCH

The human papillomavirus E7 oncoprotein as a regulator of transcription

(2017) William K. Songock et al.   VIRUS RESEARCH

Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes

(2017) Cary Moody   Viruses-Basel

EBV and Apoptosis: The Viral Master Regulator of Cell Fate?

(2017) Leah Fitzsimmons et al.   Viruses-Basel

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway

(2017) Martin Fischer et al.   Scientific Reports

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction

(2016) Agostinho Lemos et al.   MEDICINAL RESEARCH REVIEWS

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

(2016) Denise Martinez-Zapien et al.   NATURE

Global burden of cancers attributable to infections in 2012: a synthetic analysis

(2016) Martyn Plummer et al.   Lancet Global Health

Gain of function of mutant p53: R282W on the peak?

(2016) Y Zhang et al.   Oncogenesis

Carcinogenic human papillomavirus infection

(2016) Mark Schiffman et al.   Nature Reviews Disease Primers

Clinical Overview of MDM2/X-Targeted Therapies

(2016) Andrew Burgess et al.   Frontiers in Oncology

An overview of new biomolecular pathways in pathogen-related cancers

(2015) Maria Lina Tornesello et al.   Future Oncology

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

(2015) YEE-LIN VOON et al.   ONCOLOGY REPORTS

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

(2015) Ketaki Ganti et al.   Viruses-Basel

Novel Functions of the Human Papillomavirus E6 Oncoproteins

(2015) Nicholas A. Wallace et al.   Annual Review of Virology

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides

(2015) Christina Stutz et al.   PLoS One

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture

(2015) Pasha Apontes et al.   Oncotarget

High-risk HPV16E6 stimulates hADA3 degradation by enhancing its SUMOylation

(2014) Vaibhav Chand et al.   CARCINOGENESIS

Human Viral Oncogenesis: A Cancer Hallmarks Analysis

(2014) Enrique A. Mesri et al.   Cell Host & Microbe

The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6

(2014) Katia Zanier et al.   PLoS One

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

Inhibitors of the p53/hdm2 protein–protein interaction—path to the clinic

(2013) Jean-Christophe Carry et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein

(2013) Takeo Ohsugi et al.   CARCINOGENESIS

Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections

(2013) Maria Lina Tornesello et al.   GENOMICS

High-Affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens

(2013) S. Borchert et al.   JOURNAL OF VIROLOGY

p53 Tumor Suppressor Protein Stability and Transcriptional Activity Are Targeted by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factor 3

(2013) P. Baresova et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

(2013) X Xie et al.   ONCOGENE

Hepatitis C Virus NS2 Protein Inhibits DNA Damage Pathway by Sequestering p53 to the Cytoplasm

(2013) Cintia Bittar et al.   PLoS One

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

(2013) K. Zanier et al.   SCIENCE

The human papillomavirus family and its role in carcinogenesis

(2013) Massimo Tommasino   SEMINARS IN CANCER BIOLOGY

Papillomavirus E6 oncoproteins

(2013) Scott B. Vande Pol et al.   VIROLOGY

Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53

(2012) Lili Li et al.   CELL CYCLE

p53 controls hepatitis C virus non-structural protein 5A-mediated downregulation of GADD45  expression via the NF- B and PI3K-Akt pathways

(2012) D. Cheng et al.   JOURNAL OF GENERAL VIROLOGY

Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity

(2012) E. A. White et al.   JOURNAL OF VIROLOGY

Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis

(2012) Linda Zane et al.   Retrovirology

Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells

(2011) N. Nor Rashid et al.   JOURNAL OF GENERAL VIROLOGY

Comparative Analysis of Transforming Properties of E6 and E7 from Different Beta Human Papillomavirus Types

(2011) I. Cornet et al.   JOURNAL OF VIROLOGY

Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival

(2011) Shoba Iyer et al.   MOLECULAR CARCINOGENESIS

Interference with p53 functions in human viral infections, a target for novel antiviral strategies?

(2011) Pedro A. Lazo et al.   REVIEWS IN MEDICAL VIROLOGY

Epstein-Barr Virus Nuclear Antigen 3C Stabilizes Gemin3 to Block p53-mediated Apoptosis

(2011) Qiliang Cai et al.   PLoS Pathogens

Beta-HPV 5 and 8 E6 Promote p300 Degradation by Blocking AKT/p300 Association

(2011) Heather L. Howie et al.   PLoS Pathogens

Kaposi’s sarcoma-associated herpesvirus-encoded LANA positively affects on ubiquitylation of p53

(2010) Tohru Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

Cutaneous Papillomavirus E6 Proteins Must Interact with p300 and Block p53-Mediated Apoptosis for Cellular Immortalization and Tumorigenesis

(2010) P. Muench et al.   CANCER RESEARCH

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein

(2010) Doriane A. Gouas et al.   CARCINOGENESIS

Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

(2010) R. Houben et al.   JOURNAL OF VIROLOGY

Heterochromatin silencing of p53 target genes by a small viral protein

(2010) Conrado Soria et al.   NATURE

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein–Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin

(2010) Jie Lu et al.   VIROLOGY

Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis

(2010) Priya Kannian et al.   Viruses-Basel

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

Bim Nuclear Translocation and Inactivation by Viral Interferon Regulatory Factor

(2010) Young Bong Choi et al.   PLoS Pathogens

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

(2009) Joerg Kallen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Minimum Replication Origin of Merkel Cell Polyomavirus Has a Unique Large T-Antigen Loading Architecture and Requires Small T-Antigen Expression for Optimal Replication

(2009) H. J. Kwun et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway

(2009) H.-R. Lee et al.   JOURNAL OF VIROLOGY

MDM2-Dependent Inhibition of p53 Is Required for Epstein-Barr Virus B-Cell Growth Transformation and Infected-Cell Survival

(2009) E. Forte et al.   JOURNAL OF VIROLOGY

NFX1-123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E6 Keratinocytes

(2009) R. A. Katzenellenbogen et al.   JOURNAL OF VIROLOGY

A review of human carcinogens—Part B: biological agents

(2009) Véronique Bouvard et al.   LANCET ONCOLOGY

Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein–Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells

(2009) B Renouf et al.   LEUKEMIA

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2

(2009) Lingling Xian et al.   MOLECULAR BIOLOGY REPORTS

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Epstein–Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities

(2009) Fuming Yi et al.   VIROLOGY

Expression of Epstein–Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription

(2009) Yoshitaka Sato et al.   VIROLOGY

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4

(2009) M. E. Perry   Cold Spring Harbor Perspectives in Biology

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Degradation of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex

(2009) Yoshitaka Sato et al.   PLoS Pathogens

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

(2008) M. Shuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE