Journal
VIROLOGY
Volume 484, Issue -, Pages 22-32Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.05.007
Keywords
Epstein Barr Virus; Gastric Cancer; LMP2A; Human Leukocyte Antigen; Sonic Hedgehog pathway; Gli1
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Funding
- Council of Scientific & Industrial Research (CSIR), Government of India
- IBOP Project, Department of Atomic Energy (DAE), Government of India
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One of the immune evasion strategies manifested by malignant cells is the downregulation of the Human Leukocyte Antigen (HLA). HLA Class I (HLA- A, -B, -C) present endogenous peptides including viral and tumor antigens to cytotoxic T lymphocytes for immune mediated destruction. We have found the Epstein Barr Virus (EBV) Latent Membrane Protein 2A (LMP2A) to be responsible for this HLA downregulation in gastric cancer cells. Our results further indicate the Sonic Hedgehog pathway; primarily Gli1 to bring about the LMP2A mediated decrease in HLA expression. (C) 2015 Elsevier Inc. All rights reserved.
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